Award Data

ABSTRACT New strategies to improve adoptive cell therapy (ACT) protocols are emerging to enhance in vivo persistence of adoptively transferred tumor epitope-specific T cells and overcome tumor-induced immunosuppression. Our preliminary data suggests that there is a direct correlation between the long-lived central memory T cells (Tcm) and their anti-oxidant capacity. Overexpression of thioredoxin- ...

Project Summary Sialoglycans are sialic acid-containing oligosaccharides that play important biological roles in human biology and pathology and are indispensable molecular probes for research related to bacterial and viral infection, cancer metastasis, immune regulation, etc. The multifaceted functions of sialoglycans in human milk are also being explored. Nevertheless, sialoglycan-related resear ...

PROJECT SUMMARYMicroprocessor-controlled ankles have been shown to substantially improve mobility and stability in individuals with lower limb amputation, but these devices are typically only available to higher mobility users due to a lack of scientific evidence to justify insurance reimbursement. As such, many of the individuals with lower limb amputation that have the greatest need for advanced ...

Abstract It is increasingly recognized that erectile dysfunction (ED) not only affects a man’s sex life but also impacts his relationships and overall psychological well-being. An indication of the importance of erectile function to men is that, in the first 6 years after FDA approval of Viagra® (sildenafil, an oral treatment for ED), 23 million men worldwide filled Viagra® prescriptions, with ...

PROJECT SUMMARY—More than 2 million Americans are hospitalized each year with bone fractures, and many more undergo outpatient procedures for fracture reduction and fixation. Some injuries can be treated with closed reduction and splinting or casting to immobilize the bone during healing. However, at some sites, more than half of fractures require open reduction and internal fixation. Despite ad ...

PROJECT SUMMARY The American Academy of Dermatology reports that 1 in 4 Americans (~84.5 million) are impacted by skin disease. Skin disease is the fourth leading cause of disability worldwide, significantly impacts quality of life, and costs ~$75 billion annually to treat. Skin conditions like atopic dermatitis (AD) are commonly diagnosed by practitioners using clinical history and physical exam ...

PROJECT SUMMARY Despite a growing need for smoking cessation services, Latino smokers face notable disparities in cessation treatment. Consequently, there is a big opportunity, both from a scientific and a business perspective, to develop and test the most optimal culturally tailored approaches to enroll and engage Latino Smokers into cessation programs. The Kick Buts program owned by Agile Health ...

The world is rapidly heading towards a pre-1940’s scenario when it comes to fighting infectious disease. Antimicrobial resistance is a growing problem on a global scale, greatly hampering our abilities to quell worldwide epidemics such as influenza, SARS, COVID-19, tuberculosis and malaria, as well as the simple staphylococcus infection. Unless innovative strategies are developed to produce robu ...

Summary: Ovarian cancer is the leading cause of death from gynecologic malignancy. Most women are diagnosed with metastatic ovarian cancer, and the 5-year survival rate for this late stage disease is less than 28%. The mainstay of treatment for ovarian cancer entails debulking cytoreductive surgery in combination with adjuvant chemotherapies. Unfortunately, severe side effects of these chemotherap ...

Summary: According to the most recent CDC report, the incidence of sepsis in the United States is over 1.7 million each year, resulting in about 270,000 deaths and over $20 billion in healthcare costs. Sepsis results from infection of any microorganisms with bacteria being the most common. Pathogen-associated molecular patterns (PAMPs), such as lipopolysaccharides (LPS) activate innate immune cell ...