Award Data

The Defense Threat Reduction Agency (DTRA) needs a capability to collect and provide immediate presumptive analysis of radiological/nuclear samples of concern at the source of collection. Such in-field technologies should be capable of detecting and identifying trace quantities of elements and/or chemicals containing plutonium (Pu) and uranium (U), with a focus on chemicals specific to the nuclear ...

Machine learning algorithms have demonstrated performance on par with or superior to human analysts on large datasets when sufficient training data is available. For many military applications, sufficient truthed data over relevant operating conditions does not exist and is prohibitively expensive to obtain. A potential solution to thislack of measured datais synthetic data derived from physics si ...

AwareAbility Technologies (AAT), in collaboration with The Ohio State University (OSU), proposes to develop a small hand-held analysis kit for in-field analysis of trace amounts of Uranium (U) and Plutonium (Pu) that will meet or exceed the requirements set by DTRA. Swipe, dust, or water samples would be analyzed by this kit for isotopes and isotopic ratios to indicate the special nuclear material ...

Project Summary/Abstract Pancreatic cancer is a devastating disease with a very low (8%) 5-year survival rate. Therapeutic options are limited in efficacy and many have substantial toxicity. Targeted drug delivery may improve the therapeutic index of cancer drugs by enhancing drug localization to the cancer cell while minimizing off-target side effects. Sigma-2 receptors (S2R) are highly expressed ...

Project Description: The pathophysiology of traumatic spinal cord injury (SCI) involves the initial physical impact, which leads to secondary injury cascades of degenerative cellular and molecular events. The secondary injury spreads along the spinal cord over time, which adds new levels of disability and has devastating effects. Excess reactive oxygen species (ROS) formation at the impact site is ...

Mitofusin agonists to prevent Charcot-Marie-Tooth disease 2A Gerald W Dorn II, MD Mitochondria in Motion, Inc. Washington University in St Louis School of Medicine Abstract: Charcot-Marie-Tooth (CMT) disease type 2A is an incurable, primarily pediatric, autosomal dominant neuromuscular degenerative disease caused by mutations in the mitofusin (MFN) 2 gene. There are currently no disease-altering t ...

ABSTRACT With cone-beam CTandapos;s introduction in dentistry, dental clinicians could not only have profound knowledge of oral pathology but could also enhance the access to a detailed view of the underlying structures and their relations. Dental CBCT could be justified for presurgical diagnosis, preoperative planning and preoperative transfer for oral implant rehabilitation. The image quality of ...

Suramin for Recluse Spider Bites: SpiderTek, a biotechnology company that developed the first spider bite diagnostic test, proposes therapy for bites due to Loxoscelesthre erecclulseusspiade,r, using suramin, a century-old treatment for African sleeping sickness. A population of 80 million in the South-Central US shares homes with the recluse spider. Each year, an estimated 30,000 persons suffer r ...

SummaryAutoimmune uveitis is a major cause of blindness in which retinal antigen-specific T cells lead to ocular inflammation and vision loss. Similar to the treatment of other T cell-mediated autoimmune diseases, selective suppression of the pathogenic T cells is the “holy grail” of therapeutic development. In pilot studies, we have developed a novel antibody-drug conjugate (ADC) with combine ...

ABSTRACTThis Phase II STTR application from Caeli Vascular, LLC entails a 24-month period focused on further development of a novel multi-modal venous thrombectomy device. The PI is a vascular surgeon with biomedical research and entrepreneurship experience, and is supported by a team of highly qualified investigators, including a vascular biologist, neurosurgeon, veterinarian, biomedical engineer ...