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Although signal transduction inhibitors occasionally offer clinical benefit for cancer patientssignal flux emanating from oncogenes is often distributed through multiple pathwayspotentially underlying the resistance which causes failure of most such inhibitorsMeasuring signal flux through multiple pathwaysin response to signal transduction inhibitorsmay help uncover network interactions that contr ...

SUMMARY ABSTRACT Inoverorgan transplants were performed in the United Statesan increase ofover the pastyearsOrgan transplantation requires lifelong immunosuppression to prevent rejection of the transplantTacrolimusa macrolide antibioticis one of the most effective immunosuppressantswith andgtof solid organ transplant recipients receiving it as part of their maintenance immunosuppressionTacrolimus ...

Acute kidney injuryAKIcontributes to mortality and morbidity in critically ill neonatesThe identification and treatment of AKI are currently based on serum creatininesCrlevelshowevermounting evidence suggests that sCr alone is insufficient to predict or prevent renal injurysCr is in fact a measure of renal functionnot injurysCr levels usually rise many hours after a renal injuryrequire a substanti ...

Abstract Polychromatic flow cytometryFCis one of the most powerful analytical techniques routinely used by both basic research and clinical diagnostics laboratories for the immunological categorization of cellsDyes used for FC typically exhibit broad fluorescent emission bands with full width at half maximumfwhmvalues ofnmThis limits the maximum number of dyesand thus the number of cell biomarkers ...