Award Data

DESCRIPTION (provided by applicant): The overall objective of this SBIR proposal is to develop and commercialize a human 3D or mini- liver bioassay system suitable for real-time analysis of metabolic functions and long-term drug toxicity profiles. At present, liver functions are mostly studied using HepG2 cell line and primary hepatocytes cultured onto collagen or polymer matrices. However, these ...

DESCRIPTION (provided by applicant): The overall objective of this study is to develop a novel in vitro microfluidic platform to test a drug or delivery vehicle's ability to permeate the Blood-Brain Barrier (BBB). In contrast to current in-vitro models, our proposed device, SIM-BBB, comprises of a microfluidic two-compartment chamber. The chamber is designed in such a way as to permit vis ...

DESCRIPTION (provided by applicant): The separation of enantiomers (i.e. chiral separations) is of great importance in the development of safe chiral pharmaceuticals and the study of chiral biological toxins and carcinogens. For pharmaceutical compounds that are chiral, usually one enantiomer (either the right or left-handed version) is the drug, while the other half causes side effects, differen ...

DESCRIPTION (provided by applicant): The importance of reducing the incidence of secondary injuries related to manual wheelchair (MWC) propulsion is undisputed. Based on several research studies, approximately 50% of manual wheelchair users (MWU) report symptoms of repetitive strain injury (RSI) related to the demand on the upper extremity during propulsion and transferring tasks. A substantial e ...

DESCRIPTION (provided by applicant): This application is for a SBIR Phase II grant. One of the major causes of morbidity and mortality of low birth weight neonates relates to injury, inflammation, perforation and obstruction of the lower GI tract, which can be manifest in the related diseases Necrotizing Enterocolitis (NEC) and Spontaneous Intestinal Perforation (SIP). These digestive diseases, wh ...

DESCRIPTION (provided by applicant): In this fast-track application, we propose to develop a Computer Adaptive Test (CAT) to provide universal ongoing, continuous progress assessment data of critical reading skills to teachers of students in grades 4 to 8.The primary purpose of this assessment will be to facilitate a teacher's ability to provide differentiated instruction for all students in ...

DESCRIPTION (provided by applicant): This is a proposal to conduct a multi-center, double-blind, sham-controlled partial cross-over interventional study to test safety and efficacy of our novel tinnitus therapy. The tinnitus field generally accepts that elevated synchronous spontaneous activity in the auditory cortex may account for the tinnitus percept that arises following hearing loss. Followin ...

DESCRIPTION (provided by applicant): The incidence and geographic distribution of Lyme disease in the U.S. has increased steadily since its first description in 1977. Efforts to stem the spread of the disease through controlling the population of its tickvector and/or the mouse reservoirs of the disease have met with only limited success. The only approved human vaccine to protect against Lyme di ...

DESCRIPTION (provided by applicant): This proposal involves the development of a high-throughput self-interaction chromatography (SIC) system that will be used by Soluble Therapeutics, LLC, to improve and accelerate the formulation discovery process for biopharmaceuticals (i.e. vaccines, monoclonal antibodies and other therapeutic proteins). Biopharmaceuticals are used to treat a variety of infect ...

Label-free, highly sensitive early cancer detection sensors with required specificity are in great demand. In Phase 1, we experimentally confirmed feasibility of our proposed photonic crystal (PC) microarray with real data better than all reported sensing methods. These include absolute biomolecule mass sensitivity 8.8attograms (10A-18grams), surface mass sensitivity 0.8picogram (10A-12grams)/m ...