Award Data

DESCRIPTION (Verbatim from the Applicant's Abstract): More than 15 million patients in the US alone suffer from recalcitrant non-healing wounds with an estimated expenditure of greater than $10 billion in treatment costs. The demographic shift in longevity will mean an increase in the population base that is at risk of suffering from chronic non-healing wounds ...

Collagen based biosynthetic materials have profoundly improved the outcome of reconstruction and restoration of congenital defects and traumatic injuries. This has been most apparent for massive burn victims that historically suffered lifelong severe scarring and lost of function following wound closure before the advent of these materials. Unfortunately the failure rate for biosynthetic implants ...

DESCRIPTION (provided by applicant): Burn injuries represent the most terrifying and horrific trauma imaginable. This image is conditioned, in part, from the appearance of surviving bum victims that have been horribly scarred and disfigured follow

DESCRIPTION (provided by applicant): Abstract Indwelling catheterization is a leading cause of nosocomial infections that present an enormous drain of health care funding in the US. Clinical infections associated with urinary catheterization have been estimated to add more than $1000 to patient care. Those that occur with central venous catheterization escalate the cost to between $35,000 and $50, ...

DESCRIPTION (provided by applicant): Stroke is the third leading cause of death in the U.S. and a major source of disability. Ischemic stroke, the most common type, is associated with a dramatic increase in calcium influx in brain tissue, an increased production in reactive oxygen species (ROS), cell death and inflammation. Studies by the PI have shown that retinoids block neuronal voltage-gated c ...

DESCRIPTION (provided by applicant): The overall purpose of this Phase I SBIR application is conduct of research to address the scientific and technical feasibility of using diammine (also spelled diamine in the literature) silver fluoride as a topical age nt to arrest the progression of tooth decay, and to conduct the initial work that, in the longer run, will result in FDA 510 K approval of an i ...

DESCRIPTION (provided by applicant): Submerged Electro-Spark Deposition (SESD, US patent pending), developed at Advanced Surfaces And Processes, Inc., is a surface modification technique. Any conductive surface can be modified with regards to surface texture and chemical composition. The objective of the present proposal is to use SESD to incorporate appreciable amounts of bone mineral elements, i ...

DESCRIPTION (provided by applicant): Pressure ulcers affect approximately 1.7 million patients in the U.S. The overall cost to the healthcare industry for treating pressure ulcers in the U.S. is estimated to exceed $7 billion, and it is well established that the cost of preventing a pressure ulcer is significantly less than its treatment. Skin breakdown is frequently seen in individuals with bot ...

DESCRIPTION (provided by applicant): ModelTalker is a text-to-speech synthesis (TTS) system intended to be of particular interest to potential Augmentative and Alternative Communication (AAC) device users. Most present AAC devices use TTS software that derives from rule-based formant synthesis algorithms developed in the 1970s, but modern concatenative synthesis systems (of which ModelTalker is an ...

DESCRIPTION (provided by applicant): This project encompasses development and testing of a concatenative text-to-speech (TTS) synthesis system known as ModelTalker and software called InvTool which guides individuals in creating personal synthetic voices for use with ModelTalker. The overall system is intended to be of particular interest to Augmentative and Alternative Communication (AAC) device ...