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The Award database is continually updated throughout the year. As a result, data for FY19 is not expected to be complete until April, 2020.

  1. Immuno-PCR for Detection of Toxins in Medicinal Cannabis

    SBC: COURTAGEN LIFE SCIENCES, INC.            Topic: NIDA

    Abstract The overall goal of this project is to develop an optimized assay design and development process to permit the rapid implementation of sensitive bead based immuno PCR assays for the detection of the major bacterial and fungal toxins that are produced by common contaminants of medicinal cannabis The assay process will be developed and validated in Phase I focusing on one important small ...

    SBIR Phase I 2017 Department of Health and Human ServicesNational Institutes of Health
  2. Development of a Novel Specific and Sensitive Mass Spectrometry Based Protein Ligand Binding Assay to Discover Novel Beta Lactam Antibiotics

    SBC: WARP DRIVE BIO, LLC            Topic: NIAID

    ABSTRACT There is a critical need to discover and develop safe and effective antibiotics for the treatment of multidrug resistant bacterial infections Each year approximately million patients in the US get hospital acquired infections HAIs with a mortality rate of Nearly of the bacteria causing HAIs are resistant to at least one commonly used antibiotic Natural products NPs a ...

    SBIR Phase I 2017 Department of Health and Human ServicesNational Institutes of Health
  3. Point of Care Sensor for Host Gene Response to Pathogen Infection

    SBC: Giner, Inc.            Topic: NIAID

    PROJECT SUMMARY ABSTRACT Point of Care Sensor for Host Gene Response to Pathogen Infection Respiratory tract infections rank as one of the leading causes of illness and death in the world The lack of rapid easy to use and accurate point of care POC diagnostics for early detection of pathogen infections is a main reason behind inappropriate use of antibiotics and the emergence of antibiotic res ...

    SBIR Phase I 2017 Department of Health and Human ServicesNational Institutes of Health
  4. High throughput multiplexed characterization and modeling of antibody antigen binding with application to HSV

    SBC: Carterra, Inc.            Topic: NIAID

    Abstract All therapeutic antibodies and most vaccines critically depend on the ability of antibodies to specifically recognize particular antigens consequently detailed characterization of antibody antigen binding can provide invaluable information to understand and guide development Unfortunately due to the time and expense required atomic resolution structure determination is typically use ...

    SBIR Phase I 2017 Department of Health and Human ServicesNational Institutes of Health
  5. Retinal birefringence imaging for pediatric vision screening

    SBC: REBISCAN, Inc.            Topic: NEI

    Project Summary Abstract ! Amblyopia is vision loss caused by neglect of a structurally normal eye due to strabismus asymmetric refraction anisometropia or deprivation It is irreversible if not treated by age but half of all patients in the US are undetected and untreated until after it is too late making it the leading cause of preventable vision loss REBIScan has developed retinal bir ...

    SBIR Phase I 2017 Department of Health and Human ServicesNational Institutes of Health
  6. Surgical Wound Closure Matrices for the Prevention of Superficial Incisional SSI

    SBC: GEL4MED, INC.            Topic: 300

    The goal of this Phase I SBIR proposal is to test the feasibility of an intra tissue antimicrobial surgical wound matrix in the prevention of superficial surgical site skin infections Surgical Site Infections SSI are the second most common type of health care associated infection HAI occurring in to of patients undergoing surgery in the United States and accounting for approximately ...

    SBIR Phase I 2017 Department of Health and Human ServicesNational Institutes of Health
  7. New Targeted BDNF Nanoparticles for Treatment of Dopaminergic Neurodegeneration in METH Addiction and HAND

    SBC: ExQor Technologies Inc            Topic: NIDA

    ABSTRACT Methamphetamine METH addiction and Human immunodeficiency virus HIV associated neurocognitive disorder HAND represent major chronic health problems in the US and abroad Magnetic Resonance Imaging MRI studies have consistently shown structural and functional abnormalities in the dopaminergic system while Positron Emission Tomography PET studies reported dopamine transporter DA ...

    SBIR Phase I 2017 Department of Health and Human ServicesNational Institutes of Health
  8. Development of a DNA Aptamer Based Electrochemical Assay for Acetazolamide in Urine Using a Handheld Biosensor for Compliance Validation in Clinical Drug Trials

    SBC: ApolloDx , LLC            Topic: NIDA

    Development of a DNA Aptamer Based Electrochemical Assay for Acetazolamide in Urine Using a Handheld Biosensor for Compliance Validation in Clinical Drug Trials Thirty to over eighty percent of patients enrolled in pharmaceutical clinical trials do not comply with trial protocols by discarding the drug under investigation or not using the proper dosages This common practice compromises the medica ...

    SBIR Phase I 2017 Department of Health and Human ServicesNational Institutes of Health
  9. Pressure Management Technologies for Oxygenation of Implanted Insulin Secreting Cells

    SBC: Giner, Inc.            Topic: NIDDK

    PROJECT SUMMARY This Phase I program is aimed at achieving high viability and function of insulin secreting cells through sustained O delivery to implanted tissues Giner has successfully demonstrated the benefits of supplemental O in the survival and function of pancreatic islets in a densely packed immunoisolation device The first proposed application of this platform technology is pancreatic ...

    SBIR Phase I 2017 Department of Health and Human ServicesNational Institutes of Health
  10. Social Skills Coach An innovative multi platform device to address social impairments among individuals with schizophrenia

    SBC: C4 Innovations, LLC            Topic: 104

    Project Summary Schizophrenia is a serious mental health condition that affects percent of the worldandapos s population and can involve delusions hallucinations disorganized thinking lack of motivation decreased emotional expression and poor psychosocial functioning To address the need for developing social skills among people with schizophrenia and other serious mental illnesses the evi ...

    SBIR Phase I 2017 Department of Health and Human ServicesNational Institutes of Health

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