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The Award database is continually updated throughout the year. As a result, data for FY19 is not expected to be complete until April, 2020.

  1. HCV dipstick for resource-limited blood banks

    SBC: DIAGNOSTICS FOR THE REAL WORLD LIMITED            Topic: N/A

    DESCRIPTION (provided by applicant): According to WHO statistics on blood safety, 80% of the world's population has access to 20% of the world's safe blood supply. However, more than 40% (13,000,000 units) of the blood supply in the developing world is not tested for the three major transfusion-transmissible infections: human immunodeficiency virus (HIV), hepatitis B virus (HBV) and hepatitis C vi ...

    SBIR Phase II 2005 Department of Health and Human Services
  2. Triplex HBV, HCV an HIV dipstick for blood banks

    SBC: DIAGNOSTICS FOR THE REAL WORLD LIMITED            Topic: N/A

    DESCRIPTION (provided by applicant): According to WHO statistics on blood safety, 80% of the world's population has access to 20% of the world's safe blood supply. However, more than 40% (13,000,000 units) of the blood supply in the developing world is not tested for the three major transfusion-transmissible infections: human immunodeficiency virus (HIV), hepatitis B virus (HBV) and hepatitis C vi ...

    SBIR Phase II 2005 Department of Health and Human Services
  3. Nuclear Transcription Factor Translocation Assay

    SBC: DISCOVERX CORPORATION            Topic: N/A

    DESCRIPTION (provided by applicant): Transcription factors (TF) are key regulators of gene expression. Most TFs reside in the cytosol and when activated translocate to the nucleus to stimulate gene activity. A therapeutically important TF is NFkB which stimulates genes involved in cell cycling, proliferation and inflammatory responses and is an important molecular target for the development of an ...

    SBIR Phase II 2005 Department of Health and Human Services
  4. Array-microscope slide scanner system

    SBC: DMetrix, Inc            Topic: N/A

    DESCRIPTION (PROVIDED BY APPLICANT): We propose the development of an innovative, economical, array-microscope digital slide scanner to generate virtual slides in histopathology. This instrument will be capable of scanning a microscope slide in a single sweep at a numerical aperture of NA = 0.65, covering the entire width and length of a slide with 0.47- um sampling. The fundamental innovation con ...

    SBIR Phase II 2005 Department of Health and Human Services
  5. Array microscope image-acquistion system

    SBC: DMetrix, Inc            Topic: N/A

    DESCRIPTION (provided by applicant): DMetrix is developing an innovative array-microscope technology to generate virtual slides in histopathology and cytology. The innovation consists of the use of an array of miniaturized objectives, each measuring approximately 2 mm in diameter and 10 mm in length, slightly staggered in the array, to produce a single, seamless sweep of the microscope slide. In ...

    SBIR Phase II 2005 Department of Health and Human Services
  6. Topical Use of TEAC to Treat Cutaneous Viral Infection

    SBC: Dow Pharmaceutical Sciences            Topic: N/A

    DESCRIPTION (provided by applicant): Common warts, those found on the hands, tops of the feet, and sometimes on the face, arms and legs, may persist for years and may increase in size and number. Some warts may convert to cancers, and the wart virus, human papillomavirus, is the cause of cervical cancer accounting for more than 250,000 deaths annually of women worldwide. The objectives of this pro ...

    SBIR Phase II 2005 Department of Health and Human Services
  7. Novel CEHC Derivatives for Neuroinflammation

    SBC: Encore Pharmaceuticals, Inc.            Topic: N/A

    Experimental studies conducted under an SBIR Phase I (SBIR I) Grant, 1 R43 AG023510, have identified a compound that is a potential treatment for Amyotrophic Lateral Sclerosis (ALS). Encore Pharmaceuticals, Inc. (EncorePharma ) holds a composition of matter patent for the compound. The compound's mode of action in in vitro testing and its activity in preliminary studies in the G93A-SOD1 mouse mode ...

    SBIR Phase II 2005 Department of Health and Human Services
  8. Novel Monoclonal Antibody Therapy for Cancer

    SBC: GALAXY BIOTECH, LLC            Topic: N/A

    DESCRIPTION (provided by applicant): The overall objective of the application is to perform necessary studies in preparation for conducting clinical trials in cancer of a humanized antibody that neutralizes hepatocyte growth factor (HGF). Previously, a novel mouse monoclonal antibody (mAb) L2G7 was generated that inhibits the ability of HGF to bind to its receptor Met, to induce proliferation of n ...

    SBIR Phase II 2005 Department of Health and Human Services
  9. Safety of Lung Delivered Tissue Plasminogen Activator

    SBC: HTD Biosystems Inc.            Topic: N/A

    DESCRIPTION (provided by applicant): The acute respiratory distress syndrome (ARDS) represents a significant health hazard that is associated with high morbidity and mortality rates. Unfortunately, little progress has been made in advancing the treatment of ARDS. Phase I STTR funding supported the successful determination of a feasible formulation of tissue plasminogen activator (tPA) for pulmona ...

    STTR Phase II 2005 Department of Health and Human Services
  10. Development of a Multi-State Decoding Framework

    SBC: ILLUMINA, INC.            Topic: N/A

    DESCRIPTION (provided by applicant): This proposal aims to increase the information content and decrease the cost of the Illumina random array platform. Random arrays are assembled by attaching DMA probes to silica beads and loading the beads onto an etched substrate. The bead identities are determined through a sequential hybridization based decode process. Once the arrays are decoded, they ca ...

    SBIR Phase II 2005 Department of Health and Human Services

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