Award Data

DESCRIPTION (provided by applicant): This SBIR Phase II project will develop and evaluate a more practical and comprehensive approach to standardizing the self-assessment of disease-specific Health-Related Quality of Life (HRQOL) in the growing population of aging (45+ years) adults with, and at-risk of, co-morbid chronic conditions. Specifically, we propose to simplify disease impact screening (f ...

DESCRIPTION (provided by applicant): Influenza viruses are highly contagious negative-sense RNA viruses cause approximately 114,000 hospitalizations and 20,000 deaths annually. Several drugs are approved by the US Food and Drug Administration (FDA) for treating influenza infections, but successful treatment depends on knowing the specific antigenic subtype and administering these drugs within the ...

DESCRIPTION (provided by applicant): Building on the accomplishments of the prior Phase I and Phase II NIH SBIR grants in which Infoscitex was the lead institution and MIT was the subcontractor, in this Phase II competitive renewal grant application we propose to develop a commercial quality catheter guidance system that will allow clinicians to treat ventricular tachycardia (VT) with radio freque ...

DESCRIPTION (provided by applicant): Influenza virus-like particles (VLPs) have demonstrated in preclinical studies that they are highly immunogenic and efficacious in protecting against influenza infections. This emerging vaccine technology not only creates new vaccine candidates with alternative routes of administration (intranasal or intramuscular) but also implements a fast, flexible, and depe ...

DESCRIPTION (provided by applicant): Abstract There are over 40 lysosomal storage disorders, and most of these diseases affect adversely the central nervous system (CNS). The mainstay of treatment is enzyme replacement therapy (ERT). However, ERT is not effective for the brain, because the enzymes do not cross the brain capillary wall, which forms the blood-brain barrier (BBB) in vivo. Without tre ...

DESCRIPTION (provided by applicant): Although there are strain rate imaging products on the market today, none are able to provide real-time, regionally-specific, quantitative measurements of myocardium mechanics in multiple dimensions. Doppler- based strain rate imaging (SRI) implementations compromise image quality in order to provide adequate signal to noise ratio strain rate images. In additio ...

DESCRIPTION (provided by applicant): The threat of terrorist attacks using biological weapons continues to be a major national security issue. A new congressional report (www.preventwmd.gov, Dec 3, 2008) indicates that a terrorist attack with bioweapons or other weapons of mass destruction might occur before 2013. Plague and smallpox could be devastating bioweapons if intentionally released. A rel ...

DESCRIPTION (provided by applicant): Leptospirosis is a life-threatening zoonotic infection that causes acute renal failure and pulmonary hemorrhage. In the US, human leptospirosis is an emerging disease due to outbreaks that have occurred during disasters and sporting events and the increase in travel and recreation-related exposures. Furthermore, leptospirosis is a neglected disease which impa ...

DESCRIPTION (provided by applicant): We propose to develop a rapid, low cost, threshold assay for the detection of HIV infection of HIV vaccination trial participants. The assay we propose to develop will use our proprietary helicase dependent amplification (HDA) platform as well as a low cost device specifically designed to perform molecular tests without contaminating the laboratory with amplifi ...

Future Department of Defense (DoD) space-borne electro-optical payloads will require reliable, efficient, and lightweight cryocoolers for sensor cooling. Turbo-Brayton cryocoolers are an ideal candidate for these payloads. The technology is reliable and space proven with one unit having provided over 6 years of successful operations on the Hubble Space Telescope without any change in performance ...