Award Data

7. SUMMARY Alcohol use disorder (AUD) is the most prevalent substance use disorder worldwide and often co-occurs with chronic pain, anxiety, depression, and opioid dependence. Unfortunately, currently available medications for AUD have limited efficacy with unwanted side effects. To address this unmet medical need, we propose an SBIR Phase I U43 project in response to PAR-22-102 "Investigational N ...

PROJECT SUMMARY Alcohol Use Disorder (AUD) continues to be a significant problem, affecting 28.3 million adults in the United States, and is the third leading preventable cause of death. Disulfiram, naltrexone, and acamprosate are the only drugs approved by the Food and Drug Administration, but all three have limited efficacy and several contraindications. Given the substantial burden on society a ...

Only 3% of individuals who are blind or have low vision (BLV) have been employed in a STEM field. The lack of accessible accommodations to visually rich dynamic STEM content creates roadblocks to success for BLV students in STEM education throughout their academic journey. The goal of this SBIR is a usable system of accommodations for Interactive Digital Media (IDM), so students with profound visu ...

PROJECT SUMMARY Postoperative pain is a prevalent source of pain requiring appropriate management to reduce its impact upon quality of life. Even with the availability of several analgesics, postoperative pain is often undermedicated because of concern related to the adverse consequence of the available therapeutics (e.g., NSAIDs and opiates), including addiction and decreased survival of cancer p ...

SUMMARY Pantothenate kinase-associated neurodegeneration, PKAN, is a rare progressive neurodegenerative disorder associated with iron accumulation in the brain. The disease causes early immobility and often death by early adulthood. PKAN is caused by mutations in one of four human pantothenate kinase genes, PANK2 gene, which encodes a mitochondrial pantothenate kinase. Consistent with the clinical ...

Abstract Eysz, Inc. is developing a mobile health (mHealth) application and algorithms for diagnosing and monitoring absence epilepsy remotely. Accurate diagnosis and monitoring of seizures and therapeutic effects are critical elements of effective epilepsy treatment. Unfortunately, absence seizures are notoriously difficult to identify, leading to diagnostic delay and difficulty monitoring treatm ...

PROJECT SUMMARY GM1 gangliosidosis is lysosomal storage disease in which a key hydrolase enzyme, known as beta- galactosidase is missing in the lysosome resulting in the toxic accumulation of complex sugars called gangliosides, in particular GM1 and GA1 principally in the central nervous system. There is currently no cure or effective treatment available. A primary approach for treating related ty ...

ABSTRACT Prostate cancer is the most commonly diagnosed cancer in men, with an estimated 268,490 new cases in the U.S. in 2022. At the time of a prostate cancer biopsy, pathologists use the tumor material to determine the grade and stage. Primary treatment decisions are based on the biopsy tissue information and the PSA (prostate specific antigen, blood test). About 80% of newly diagnosed cases ar ...

Project Summary Oncologists have a great need for improved DNA sequencing technology because sequencing the DNA of cancer cells can provide valuable information about the specific mutations driving the disease and inform/guide treatment decisions. Additionally, sequencing healthy tissue can provide information about an individual's genetic risk factors for cancer. One area of particular interest i ...

PROJECT SUMMARYWhile conventional wisdom holds that individuals with longer residual limbs retain greater function, they are actually confined to low-profile feet that limit performance. In particular, low-profile feet are often much stiffer than their standard profile counterparts. As such, many of the individuals with transtibial amputation that have long residual limbs are unable to obtain pros ...