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The Award database is continually updated throughout the year. As a result, data for FY23 is not expected to be complete until September, 2024.
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A data dictionary and additional information is located on the Data Resource Page. Files are refreshed monthly.
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SBC: NEONC TECHNOLOGIES INC Topic: 102
Project Summary Abstract Many pharmaceutical agents are highly potentbut are unable to exert substantial therapeutic activity against disorders of the brainbecause the blood brain barrierBBBeffectively prevents their access to the site of intracerebral diseaseFor examplethe majority of glioblastoma patientsdespite the best efforts of current medical caredie within two years after diagnosisHencethe ...STTR Phase I 2018 Department of Health and Human ServicesNational Institutes of Health
SBC: ELECTRONUCLEICS INC Topic: NIAID
Project Summary This project is focused on feasibility testing of a new device based on electromechanical signal transduction for the low cost$in electronicsoptics free and amplification freee gno PCRdetection of DNA RNA at ultralow concentrationThe device addresses the projected $B disease diagnostics market and is well suited for the detection of bacterial pathogens in body fluidsfood and water ...STTR Phase I 2018 Department of Health and Human ServicesNational Institutes of Health
SBC: INTELLIGENT FIBER OPTIC SYSTEMS CORP Topic: NINDS
Sonomyographic Control of Fiber Optically Sensorized Prosthetic Fingers for Graded Force Actuation Intelligent Fiber Optic Systems CorporationIFOSCalle del MundoSanta ClaraCAwww ifos com PROJECT SUMMARY ABSTRACTMAXIMUMLINESIn this Phase I SBIR applicationIFOS and George Mason UniversityGMUpropose an innovative control system leveraging on two emerging technologiesultrasonic imaging based readout o ...STTR Phase I 2018 Department of Health and Human ServicesNational Institutes of Health
SBC: MITOTHERAPEUTIX LLC Topic: 300
Abstract The Specific Aim of this Phase I STTR proposal is to test the feasibility of blocking MCJalso called DnaJCto overcome acute acetaminophen liver toxicityAcetaminophen or APAPfrom acetyl paraaminophenolis a common drug used to address pain and feverIn the US aloneaboutpatients per year are admitted to intensive care units with APAP induced liver injury and close toof these patients undergo ...STTR Phase I 2018 Department of Health and Human ServicesNational Institutes of Health
SBC: AXCEND LLC Topic: R41
Project Summary Abstract Point of carePOCtesting of clinical samples for the presence of illegal substances and their metabolites is important for monitoring substance use disordersemployment screeningand legal matters relating to drug abstinenceTypical immunoassay screening methods suffer from higher false testing rates and do not provide quantitative informationConfirmatory tests that are used f ...STTR Phase I 2018 Department of Health and Human ServicesNational Institutes of Health
SBC: SIGNATURE RESEARCH, INC. Topic: 1
Signature Research, Inc. (SGR) and Michigan Technological University (MTU) propose a Phase I STTR effort to develop a learning algorithm which exploits the spatio-spectral characteristics inherent within IR imagery and motion imagery.Our archive of modelled and labeled data sets will allow our team to thoroughly capture the variable elements that will drive machine learning performance.The overall ...STTR Phase I 2018 Department of DefenseNational Geospatial-Intelligence Agency
SBC: L2 DIAGNOSTICS LLC Topic: NIAMS
ABSTRACT Systemic autoimmune diseases such as rheumatoid arthritis and systemic lupus erythematosus are characterized by polyclonal T cell activation driving the production of pathogenic class switched autoantibodiesThe class switchedsomatically mutated antibodies are generated from germinal centerGCB cellsA subset of effector CDT cellsknown as T follicular helperTfhcellshas been shown to play an ...STTR Phase I 2018 Department of Health and Human ServicesNational Institutes of Health
SBC: L2 DIAGNOSTICS LLC Topic: NICHD
ABSTRACT Kawasaki DiseaseKDis a febrile childhood vasculitis with potentially catastrophic clinical outcomesUntreatedone in five children develop coronary artery aneurysms causing significant morbidity and mortalityTypical KD presents as a febrile illness andgtdays in children andltyears oldThere are no diagnostic tests for KDit is diagnosed clinically based on a fever andgtdays with at leastofphy ...STTR Phase I 2018 Department of Health and Human ServicesNational Institutes of Health
A Novel Therapeutic that Harnesses Microtubules to Promote Cavernous Nerve Regeneration after Radical ProstatectomySBC: MICROCURES INC Topic: 300
Radical prostatectomyRPis a commonly used treatment option for localized prostate cancerUnfortunatelythe procedure carries a risk of post surgical complications including a high risk of erectile dysfunctionEDAccording to The Prostate Cancer Outcomes Studyvirtually all men experience ED after surgeryincluding a profound loss of nocturnal erectionsThe Prostate Cancer Outcomes Study further reveals t ...STTR Phase I 2018 Department of Health and Human ServicesNational Institutes of Health
A Novel Therapeutic that Harnesses MIcrotubules to Enhance Corneal Wound Healing Following an Alkaline BurnSBC: MICROCURES INC Topic: NEI
The cornea is one of the most important tissues in the eye and its transparency is critical for good visual function in humansCorneal tissue injuries are the most common everyday issue for practicing ophthalmologists and can run the gamut in severityIn severe modelssuch as corneal alkaline burnsextensive healing is needed and often the burn victim is left with reduced visual acuityHealing of large ...STTR Phase I 2018 Department of Health and Human ServicesNational Institutes of Health