Award Data

There are currently no vaccines or therapeutics available for Marburg Virus Disease (MVD). Given the specter of weaponization and the terriblemorbidity and high mortality rate of MVD, this represents a critical threat to the operational readiness of the Warfighter. While traditionalvaccines have proven to be a huge contribution to public health, they do have some limitations especially in the cont ...

Flow Pharma, Inc. is a biotechnology company in the San Francisco Bay Area developing fully synthetic cytotoxic T lymphocyte (CTL)stimulating peptide vaccines for Marburg virus. The FlowVax vaccine platform allows us to create dry powder formulations of biodegradablemicrospheres and TLR adjuvants incorporating class I and class II T cell epitopes. FlowVax vaccines can be designed for delivery by i ...

Additive Manufacturing (AM) is a modern and increasingly popular manufacturing process for metallic components, but suffers from well known problems of inconsistent quality of the finished product. Process monitoring and feedback control are therefore crucial research areas with a goal of solving this problem. To address this concern, X-wave Innovations, Inc. (XII) and the University of Dayton Res ...

In response to the challenges described in AF173-CT05, Applied Defense Solutions (ADS) and the University of New Mexico (UNM) (equivalently, the ADS Team) propose to research and develop innovative validation and verification (V&V) algorithms for spacecraft GN&C. The ADS Team is unique in that it brings operational flight GN&C software experience (ADS) with cutting edge research on algorithm V&V ( ...

The safety and operational success of the U.S. Navy (USN) depends on expert navigation, seamanship, and shiphandling skills. Tragically, the Navy experienced four major incidents in 2017. The resulting USN Comprehensive Review identified lapses in basic seamanship and safe navigation skills as contributing factors, reinforcing the critical need for rigorous shiphandling training and proficiency as ...

In this project, Citrine Informatics and the ADAPT Center at the Colorado School of Mines propose to build an informatics-driven system to understand the effects of defects in additive manufactured parts. The entire history of each sample will be captured on this system; from specific printing parameters and details of precursor materials through to part characterizations and performance measureme ...

Qualtech Systems, Inc. (QSI), in collaboration with VU proposes to develop a state-of-the art HMS system featuring: (1) Low Hardware cost by leveraging industrial-grade computers ruggedized to military specifications (2) Low Software cost by leveraging QSI’s COTS TEAMS software with real-time monitoring and diagnosis capabilities (3) Vibration and Shock Analysis and its impact on vehicle and cre ...

This effort proposes to develop situational awareness methodologies for mission critical ship system based on the state-of-the-art probabilistic knowledge graph (KG) and deep learning. The proposed KG approach can incorporate various data fusion technologies for analysis of unstructured data (text, images, etc.) and structured data (signal feeds, database items, etc.) for automated decision suppor ...

There is an urgent need to bypass or cross the blood brain barrier (BBB) to deliver drugs for TBI treatment. This project aims to develop targted intranasally delivered, magnetically propulsed, and targted nanoparticles for traumatic brain injury (TBI). In Phase I, we will demonstrate the design, fabrication, and in vitro characterization of proposed drug laden magnetic nanoparticles as well as co ...

Methods for interconversion between cell types (cellular reprogramming) are currently discovered through resource intensive trial and error. Experiments may test a multitude of transcription factors to identify correct combinations that influence cell fate. In addition, reprogramming approaches commonly use stem cell intermediates such as induced pluripotent stem cells (iPSCs), which are generated ...