Award Data

Project Summary Abstract Physical Sciences IncPSIis continuing the pursuit of new clinical applications and advanced multimodal capabilities for its novel retinal imaging technology based on an adaptive optics line scanning ophthalmoscopeAO LSOThe Compact Adaptive Optics Retinal ImagerCAORIeliminates high speed scanning componentsreduces the clinical footprint compared to research adaptive optics ...

Project SummaryAortic stenosis (AS) is a common and lethal cardiac valve disease with an average survival time of only 2 – 3 years after diagnosis if no treatment is obtained. The standard of care for moderate to severe cases of symptomatic AS is surgical valve repair or replacement, which can necessitate open heart surgery. This “gold standard” of care is plagued by substantial limitations, ...

Project Summary AbstractThere is currently a significant need for new non invasive imaging techniques able to accurately quantify biomarkers for early detectiondiagnosisand quantification of complications in typediabetesT Dsuch as diabetic retinopathyDRPhysical Sciences IncPSIproposes to develop an imaging platform based on a new detection arrangement retrofitted to an existing high resolution ret ...

Abstract The project concerns optical single molecule sequencing on a highly packed array of molecules in which individual molecules are not resolvable by standard diffraction limited imagingThe sequence of molecules is obtained by super resolving signal from individual molecules during the course of template directed DNA synthesisThe project willsynthesize and test the basic building blocks of th ...

AbstractDuring a successful Phase 2 effort, Etiometry collaborated with multiple world-class pediatric centers to develop, validate, and deploy novel analytics that combine multiple physiologic data streams into a probabilistic assessment of inadequate oxygen delivery to critically ill patients. The analytics were integrated into the Etiometry Platform with the goal of improving physician situatio ...

Preceding Award: NCI Award 1R44CA192875-02 Project Summary: According to the Oral Cancer Foundation, about 50,000 people in the US will be newly diagnosed with oral cancer (OC) in 2017, causing 9,700 deaths[1]. OC is a severely neglected orphan disease with a lack of significant treatment advances in 4 decades[1]. Historically, OC has been present in heavy smokers and drinkers. However, more recen ...

TBD

Both typeand typediabetes involve loss of insulin producing pancreaticcells resulting in inadequate insulin secretion to control blood glucoseand ultimately requiring daily insulin injections to avoid the constellation of life threatening complications that arise from long term hyperglycemiaWhile transplantation of cadaveric pancreatic islets that containcells has been successful for treating a sm ...

Project Summary Abstract The investigation of the complex neural dynamics and the cognitive functions of the brain requires noninvasive recording tools with high spatio temporal resolutionSub cellular resolution fluorescence imaging microscopybased on either voltage indicators or calcium sensitive fluorescent proteinsenables parallel recording of the activity of spatially distributed neuron popula ...

Project Summary Abstract Family caregivers are an integral part of the U Shealth care systemasof all care for persons with Alzheimer s disease is done by unpaid caregiversPersons with dementia also receive approximatelytimes the amount of informal care that a cognitively intact older adult does roughlyhours per monthSothere is an urgent need for products and programs that enable family caregivers ...