Award Data

ABSTRACT A primary challenge in ovarian cancer is preventing tumor recurrence in patients following a resection debulking procedure year survival rate andlt Intraperitoneal IP administration of chemotherapy most notably paclitaxel can improve patient outcomes and prevent local tumor recurrence the principal deterrent to long term survival However despite these modest improvement ...

Radiopharmaceutical therapyRPTis an emerging cancer treatment that delivers radiation directly to cancer cellsThe recent FDA approval ofRa Xofigotmfor resistant metastatic prostate cancer and its commercial success provides an example of the therapeutic and commercial potential of this modalityIn additiondrug companies have large libraries of targets and targeting moleculesProgress in chelators an ...

Abstract The overall goal of this project is to develop an optimized assay design and development process to permit the rapid implementation of sensitive bead based immuno PCR assays for the detection of the major bacterial and fungal toxins that are produced by common contaminants of medicinal cannabis The assay process will be developed and validated in Phase I focusing on one important small ...

Significance Despite decreases in the overall number of new breast cancer BC cases reported in the US annually there are still about BC deaths annually from metastatic breast cancer MBC Thus the ability to monitor MBC is important to determine disease status and therapy response While the gold standard imaging is expensive time consuming and slow to detect disease response o ...

ABSTRACT There is a critical need to discover and develop safe and effective antibiotics for the treatment of multidrug resistant bacterial infections Each year approximately million patients in the US get hospital acquired infections HAIs with a mortality rate of Nearly of the bacteria causing HAIs are resistant to at least one commonly used antibiotic Natural products NPs a ...

Project Summary The threat of a radiation attack or accident isunfortunatelyall too real and could potentially affect a large enough population so as to overwhelm the medical systemTo be prepared for such an eventit is necessary to stockpile effective radiation medical countermeasuresMCMthat are safeeasily administered to large numbers of peopleand effective even when treatment is delayedhrs after ...

PROJECT SUMMARY ABSTRACT Point of Care Sensor for Host Gene Response to Pathogen Infection Respiratory tract infections rank as one of the leading causes of illness and death in the world The lack of rapid easy to use and accurate point of care POC diagnostics for early detection of pathogen infections is a main reason behind inappropriate use of antibiotics and the emergence of antibiotic res ...

Project Summary Abstract ! Amblyopia is vision loss caused by neglect of a structurally normal eye due to strabismus asymmetric refraction anisometropia or deprivation It is irreversible if not treated by age but half of all patients in the US are undetected and untreated until after it is too late making it the leading cause of preventable vision loss REBIScan has developed retinal bir ...

The goal of this Phase I SBIR proposal is to test the feasibility of an intra tissue antimicrobial surgical wound matrix in the prevention of superficial surgical site skin infections Surgical Site Infections SSI are the second most common type of health care associated infection HAI occurring in to of patients undergoing surgery in the United States and accounting for approximately ...

Project Summary Abstract Cigarette smoking is responsible for nearly one half million deaths yr in the U S where direct healthcare costs to treat smoking and smoking attributable illness exceed $ billion year Only smokers achieve long term abstinence using standard of care pharmacotherapies leaving the majority still smoking and seeking alternatives The focus of this project is to ...