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The Award database is continually updated throughout the year. As a result, data for FY19 is not expected to be complete until April, 2020.

  1. ACES: A Product to Suppress or Enhance Critical Components in Acoustic Signals

    SBC: SPEECH TECHNOLOGY/APPLIED RESEARCH CORP.            Topic: NIDCD

    DESCRIPTION (provided by applicant): Common acoustic environments are often complex mixtures of sounds from multiple acoustic sources. Some of these sources contain critical information listeners need to comprehend; others are distractions that interfere with listeners6 comprehension. As the US population ages, a significant and growing segment have difficulty coping with such complex sound fi ...

    SBIR Phase I 2011 Department of Health and Human Services
  2. Optical Surgical Probe for Assessing Human Oral Mucosa Graft Vascularization

    SBC: Radiation Monitoring Devices, Inc.            Topic: NIDCR

    DESCRIPTION (provided by applicant): This proposal's main objective is the development of a novel Perfusion Monitoring Device (PMD) based upon diffuse correlation spectroscopy (DCS), which will enable microsurgeons to assess the level of vascularization ofburied (prelaminated) flaps and the successful perfusion of transplanted microvascular grafts. The PMD will shift current assessment of bur ...

    SBIR Phase I 2011 Department of Health and Human Services
  3. MMP Inhibitor For Orofacial Pain

    SBC: AQUILUS PHARMACEUTICALS INC            Topic: NIDCR

    DESCRIPTION (provided by applicant): Aquilus Pharmaceuticals, Inc. proposes to evaluate the effects of a novel matrix metalloproteinase (MMP) inhibitor on animal behavioral models of spinal and orofacial neuropathic pain. The goals for Phase I are to scale-up the synthesis of the inhibitor, determine its pharmacokinetics (PK) and then run animal efficacy studies in both the spinal nerve ligation ( ...

    SBIR Phase I 2011 Department of Health and Human Services
  4. Nano-Crystalline Ceramic Coatings for the Reduction of Sliding Resistance of Orth

    SBC: Spire Corporation            Topic: NIDCR

    DESCRIPTION (provided by applicant): In this program, nano-crystalline ceramics will be applied to the surface of orthodontic archwires using ion beam assisted deposition (IBAD) to reduce sliding resistance. Excessive sliding resistance works against toothmotion as the bracket slides along the wire into a new position, resulting in less predictable outcomes, and requiring increased force, treatmen ...

    SBIR Phase I 2011 Department of Health and Human Services
  5. Oral Antibody Therapy for Celiac Disease

    SBC: AVAXIA BIOLOGICS, INC.            Topic: NIDDK

    DESCRIPTION (provided by applicant): Celiac disease is a common and debilitating gastrointestinal disorder. It is caused by an inappropriate immunological response to gluten. Although celiac disease can usually be controlled by strict avoidance of gluten in the diet, the ubiquity of gluten in the modern diet makes such a strategy difficult and there is a need for new therapies for celiac disease. ...

    SBIR Phase I 2011 Department of Health and Human Services
  6. Hemodynamic Co-Culture Liver Model for Drug Discovery and Assessment

    SBC: HemoShear Therapeutics, LLC            Topic: NIDDK

    DESCRIPTION (provided by applicant): Drug developers desperately need better tools in the laboratory to improve the 90% failure rate of drugs in clinical trials. Liver toxicity is still the leading cause of drug failure, despite extensive preclinical testing in surrogate animal species. HemoShear develops human surrogate technologies for target ID and validation and screening of compounds for safe ...

    SBIR Phase I 2011 Department of Health and Human Services
  7. Development of a discovery platform based on microfluidics and fluorescent cell f

    SBC: NIVARTA, INC.            Topic: NIDDK

    DESCRIPTION (provided by applicant): The overall goal of the project is to develop discovery platform based on microfluidics and functional cell assays that is suitable for screening hundreds of proteins or small-molecule compounds simultaneously in a cost-effective and high throughput manner. The projects Specific Aims are: (1) To develop a microfluidic-based platform for high-throughput screenin ...

    SBIR Phase I 2011 Department of Health and Human Services
  8. Interactive Sensor Technology to Measure Adherence to Prescribed Therapeutic Foot

    SBC: BioSensics LLC            Topic: NIDDK

    DESCRIPTION (provided by applicant): Prescribed footwear, such as Removable Cast Walkers, are used to reduce harmful pressures on the bottom of the foot for prevention and treatment of diabetic foot ulceration (DFU). Although a key component to the healing and prevention of DFU, patient adherence with these devices is excessively poor as determined by patient interviews and initial objective asse ...

    SBIR Phase I 2011 Department of Health and Human Services
  9. High Resolution Scanning Magnetometry

    SBC: MOMENT TECHNOLOGIES, LLC            Topic: NIBIB

    DESCRIPTION (provided by applicant): In Phase I we propose to test the feasibility of developing a high-resolution scanning magnetometry for neuroscience based on a simple, but novel concept of primary source mirror (PRISM). The PRISM can be made with different designs, but in this project it will be an air-filled glass pipette with a small glass plate at the end with a tilt of 45o toward bottom. ...

    SBIR Phase I 2011 Department of Health and Human Services
  10. Robotic System for Minimally Invasive Neurosurgical Endoscopic Procedures

    SBC: Etiometry Inc.            Topic: NIBIB

    DESCRIPTION (provided by applicant): Sterling Point Research, in conjunction with Children's Hospital Boston, intends to develop a multi-stage robotic endoscope for neurosurgical applications. This novel robotic system will utilize recently developed concentric tube technology to give neurosurgeons the ability to overcome the limitations of manually controlled flexible endoscopes. The cur ...

    SBIR Phase I 2011 Department of Health and Human Services

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