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The Award database is continually updated throughout the year. As a result, data for FY19 is not expected to be complete until April, 2020.

  1. ONE WEEK SUSTAINED RELEASE METHADONE MICROCAPSULES

    SBC: BIOTEK, INC.            Topic: N/A

    N/A

    SBIR Phase I 1988 Department of Health and Human Services
  2. ASBESTOS TOXICITY AND CARCINOGENICITY

    SBC: BOSTON BIOTECHNOLOGY CORPORATION            Topic: N/A

    THE LONG RANGE OBJECTIVE OF THIS RESEARCH IS TO REDUCE THE TOXICITY AND CARCINOGENICITY OF ASBESTOS BY DESFERROXAMINE TREATMENT, WHICH NEUTRALIZES THE CATALYTIC ACTIVITY OF THE ASBESTOS-CONTAINED IRON. IN PHASE I OF THIS PROJECT THE POSSIBILITY THAT DESFERROXAMINE TREATMENT CAN REDUCE ASBESTOS-CAUSED SQUAMOUS METAPLASIA IN TRACHEAL ORGAN CULTURES WILL BE STUDIED. SQUAMOUS METAPLASIA IS THOUGHT TOP ...

    SBIR Phase I 1988 Department of Health and Human Services
  3. PURIFICATION OF HTLV-I RECOMBINANT ENVELOPE ANTIGEN

    SBC: Cambridge Biotech Corp.ora- Ti            Topic: N/A

    N/A

    SBIR Phase I 1988 Department of Health and Human Services
  4. NOVEL SCREENING ASSAY FOR EXCITATORY AMINO ACID ANTAGONISTS

    SBC: CAMBRIDGE NEUROSCIENCE            Topic: N/A

    EXCITATORY AMINO ACIDS (EAAS) ARE IMPLICATED IN THE PATHOLOGY OF A NUMBER OF HUMAN NEUROLOGICAL DISORDERS, INCLUDING EPILEPSY, ISCHEMIC BRAIN DAMAGE, AND NEURODEGENERATIVE DISEASES SUCH AS HUNTINGTON'S DISEASE AND ALZHEIMER'S DISEASE. THE ROLE OF EAAS IN THESE DISORDERS APPEARS TO INVOLVE ABNORMALLY ENHANCED ACTIVATION OF EAA RECEPTORS THAT LEADS TO EXCITOTOXIC CELL DAMAGE AND NEURONAL DEATH. RECE ...

    SBIR Phase I 1988 Department of Health and Human Services
  5. NOVEL, NEMATODE-SPECIFIC ANTHELMINTICS AND NEMATICIDES

    SBC: CAMBRIDGE NEUROSCIENCE            Topic: N/A

    N/A

    SBIR Phase I 1988 Department of Health and Human Services
  6. LASER FOR SELECTIVE PHOTOTHERMOATHEROLYSIS

    SBC: CANDELA CORPORATION            Topic: N/A

    CARDIOVASCULAR DISEASE IS THE LEADING CAUSE OF DEATHS IN THEUNITED STATES, CLAIMING NEARLY TWICE AS MANY LIVES AS CANCER. LASER ANGIOPLASTY HAS IMMENSE APPEAL, BUT A RELIABLE, PREDICTABLE SYSTEM HAS NOT YET BEEN DEVELOPED. RESEARCHERS HAVE CONDUCTED PRELIMINARY STUDIES TO DEMONSTRA-TE PREFERENTIAL ABSORPTION OF DYE LASER ENERGY BY ANTHERO- MATOUS PLAQUES WITH MINIMAL ABSORPTION BY NORMAL ARTERIAL ...

    SBIR Phase II 1988 Department of Health and Human Services
  7. CELL SORTING BY PHOTO-ACTIVATED DYE TAGGED ANTIBODIES

    SBC: CANDELA CORPORATION            Topic: N/A

    CANDELA LASER CORPORATION AND UCLA TISSUE TYPING LABORATORY PROPOSE TO DEVLOP A GROUP OF DYE TAGGED MONOCLONAL ANTIBODIES AND A LASER TO TARGET THESE DYES, FOR THE PEREFERENTIAL DESTRUCTION OF HUMAN T CELLS FROM A MIXTURE OFT AND B CELLS AND ALSO ACINAR CELLS IN THE PRESENT OF SLIT CELLS. THE ENVISIONED PROCEDURE IS TO ATTACH SPECIALLY MODIFIED DYES TO MONOCLONAL ANTIBODIES. THE MONOCLONALS WILL T ...

    SBIR Phase I 1988 Department of Health and Human Services
  8. PULSED DYE LASER AB-INTERNO SCLEROTOMY

    SBC: CANDELA CORPORATION            Topic: N/A

    N/A

    SBIR Phase I 1988 Department of Health and Human Services
  9. STANDARDIZED CONTRAST AGENT FOR NEUROSONOGRAPHIC IMAGING

    SBC: Cavitation-control            Topic: N/A

    N/A

    SBIR Phase I 1988 Department of Health and Human Services
  10. NOVEL HLA-LINKED DNA IN A YEAST ARTIFICIAL CHROMOSOME

    SBC: CBR LABORATORIES, INC.            Topic: N/A

    ALTHOUGH A LARGE NUMBER OF DNA CLONES EXIST WHICH COVER MANYOF THE GENES OF THE HUMAN MAJOR HISTOCOMPATIBILITY COMPLEX (MHC), A NUMBER OF LARGE GAPS EXIST, INCLUDING THE 275-300 KB REGION OF DNA BETWEEN HUMAN LEUCOCYTE ANTIGEN (HLA)-DR AND THE COMPLEMENT GENES. THE MHC ENCODES GENES DETERMING SUSCEPTIBILITY TO DISEASE, INCLUDING JUVENILE-ONSET DIABETES, GLUTEN-SENSITIVE ENTEROPATHY, AND THE BLISTE ...

    SBIR Phase I 1988 Department of Health and Human Services

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