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The Award database is continually updated throughout the year. As a result, data for FY19 is not expected to be complete until April, 2020.

  1. HOME SCREENING OF INFANT HEARING

    SBC: Bam World Markets Inc.            Topic: N/A

    A NEW, INNOVATIVE KIT FOR PARENT SCREENING OF INFANT HEARING(0-24 MONTHS) WILL BE DEVELOPED AND GIVEN TO 300 PARENT PAIRS TO VALIDATE A HOME SCREENING PROGRAM, USING SPECIAL FREQUENCY SOUND-MAKERS. OF THE APPROXIMATELY 4,000,000 BABIES BORN IN THE UNITED STATES EACH YEAR, OVER 1,000,000 DEVELOP HEARING PROBLEMS FROM RECURRENT OTITIS MEDIA DURING THEIR FIRST 24 MONTHS. APPROXIMATELY 8,000 OF THESE ...

    SBIR Phase II 1988 Department of Health and Human Services
  2. PURIFIED BOVINE HEMOGLOBIN FOR CARDIAC PRESERVATION

    SBC: BIOPURE CORPORATION            Topic: N/A

    BIOPURE CORPORATION HAS SUCCESSFULLY MANUFACTURED A POLYMERIZED BOVINE HEMOGLOBIN SOLUTION WHICH PHYSIOLOGICALLYOXYGENATES AS WELL AS OR BETTER THAN RED BLOOD CELLS. KEY PERFORMANCE CHARACTERISTICS INCLUDE BETTER 0(2)/CO(2) EXCHANGE AT THE CELLULAR LEVEL THAN FRESH HUMAN BLOOD. THE PRODUCT IS ESSENTIALLY FREE OF ENDOTOXINS, PHOSPHOLIPIDS, CLINICALLY ANTIGENIC AGENTS, PLASMA PROTEINS, LIPIDS OR OTH ...

    SBIR Phase I 1988 Department of Health and Human Services
  3. DNA PROBES FOR ANTIBIOTIC RESISTANCE IN PERIODONTITIS

    SBC: Biotechnica Diagnostics Inc            Topic: N/A

    THE USE OF ANTIBIOTIC THERAPY FOR INFECTION MANAGEMENT HAS INCREASED DRAMATICALLY IN THE AREA OF PERIODONTAL DISEASE AS AN ADJUNCT TO SCALING AND SURGERY TREATMENT. WITH THE EMERGENCE OF ANTIBIOTIC USE IN PERIODONTAL DISEASE CARE, ALMOST NO WORK HAS BEEN DONE IN ASSESSING THE DEVELOPMENT OF ANTIBIOTIC RESISTANCE IN DENTAL PLAQUE FLORA. BY DEVELOPING A DNA PROBE-BASED ASSAY FOR THE DETECTION OF ANT ...

    SBIR Phase I 1988 Department of Health and Human Services
  4. DNA PROBES FOR THE DETECTION OF PERIODONTAL PATHOGENS

    SBC: Biotechnica Diagnostics Inc            Topic: N/A

    THE ROLE OF EIKENELLA CORRODENS, FUSOBACTERIUM NUCLEATUM, AND WOLINELLA RECTA AS PATHOGENS ASSOCIATED IN DESTRUCTIVE PERIODONTAL DISEASE HAS BEEN DESCRIBED IN A NUMBER OF STUDIES USING CULTURE BASED ASSAY SYSTEMS. THE STANDARD CULTURE METHODS ARE INADEQUATE FOR THE ROUTINE DIAGNOSIS OF THESE PATHOGENS. BY DEVELOPING DNA PROBE-BASED ASSAYS FOR THE DETECTION OF THESE PATHOGENS, IT WOULD BE PRACTICAL ...

    SBIR Phase I 1988 Department of Health and Human Services
  5. DEVELOPMENT OF TRANSDERMAL ANTIHISTAMINE DELIVERY SYSTEM

    SBC: BIOTEK, INC.            Topic: N/A

    THE OVERALL OBJECTIVE OF THE PROJECT IS TO DEVELOP A TRANSDERMAL DOSAGE FORM OF THE H(1)-BLOCKER CARBINOXAMINE FOR 24-HOUR CONTROL OF ALLERGIC RHINITIS. IN PHASE I THE FEASIBILITY OF SUCH DOSAGE WILL BE TESTED. IN VITRO TRANSDERMAL PENETRATION EXPERIMENTS WITH NUDE MOUSE SKINS, AS WELL AS IN VIVO TESTS ON SHAVED RABBIT SKINS WILL BE USEDTO DETERMINE PERCUTANEOUS FLUX VALUES. FORMULATIONS OPTIMIZED ...

    SBIR Phase I 1988 Department of Health and Human Services
  6. ONE WEEK SUSTAINED RELEASE METHADONE MICROCAPSULES

    SBC: BIOTEK, INC.            Topic: N/A

    N/A

    SBIR Phase I 1988 Department of Health and Human Services
  7. ASBESTOS TOXICITY AND CARCINOGENICITY

    SBC: BOSTON BIOTECHNOLOGY CORPORATION            Topic: N/A

    THE LONG RANGE OBJECTIVE OF THIS RESEARCH IS TO REDUCE THE TOXICITY AND CARCINOGENICITY OF ASBESTOS BY DESFERROXAMINE TREATMENT, WHICH NEUTRALIZES THE CATALYTIC ACTIVITY OF THE ASBESTOS-CONTAINED IRON. IN PHASE I OF THIS PROJECT THE POSSIBILITY THAT DESFERROXAMINE TREATMENT CAN REDUCE ASBESTOS-CAUSED SQUAMOUS METAPLASIA IN TRACHEAL ORGAN CULTURES WILL BE STUDIED. SQUAMOUS METAPLASIA IS THOUGHT TOP ...

    SBIR Phase I 1988 Department of Health and Human Services
  8. PURIFICATION OF HTLV-I RECOMBINANT ENVELOPE ANTIGEN

    SBC: Cambridge Biotech Corp.ora- Ti            Topic: N/A

    N/A

    SBIR Phase I 1988 Department of Health and Human Services
  9. NOVEL SCREENING ASSAY FOR EXCITATORY AMINO ACID ANTAGONISTS

    SBC: CAMBRIDGE NEUROSCIENCE            Topic: N/A

    EXCITATORY AMINO ACIDS (EAAS) ARE IMPLICATED IN THE PATHOLOGY OF A NUMBER OF HUMAN NEUROLOGICAL DISORDERS, INCLUDING EPILEPSY, ISCHEMIC BRAIN DAMAGE, AND NEURODEGENERATIVE DISEASES SUCH AS HUNTINGTON'S DISEASE AND ALZHEIMER'S DISEASE. THE ROLE OF EAAS IN THESE DISORDERS APPEARS TO INVOLVE ABNORMALLY ENHANCED ACTIVATION OF EAA RECEPTORS THAT LEADS TO EXCITOTOXIC CELL DAMAGE AND NEURONAL DEATH. RECE ...

    SBIR Phase I 1988 Department of Health and Human Services
  10. NOVEL, NEMATODE-SPECIFIC ANTHELMINTICS AND NEMATICIDES

    SBC: CAMBRIDGE NEUROSCIENCE            Topic: N/A

    N/A

    SBIR Phase I 1988 Department of Health and Human Services

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