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The Award database is continually updated throughout the year. As a result, data for FY19 is not expected to be complete until April, 2020.

  1. Coronary Post-Dilatation Catheter

    SBC: P2D, INC            Topic: NIA

    DESCRIPTION (provided by applicant): The goal of this proposal is to develop tumor necrosis factor (TNF )-inhibiting compounds as neuroprotectant drugs for treating Alzheimer's disease (AD). Current FDA-approved AD interventions are symptomatic treatments with limited efficacy which do not affect AD etiology or modify the course of disease progression. Thus, a critical need exists for a nov ...

    SBIR Phase I 2013 Department of Health and Human Services
  2. Polaris Oncology Survivor Transition (POST) System

    SBC: TERPENOID THERAPEUTICS, INC.            Topic: NIA

    DESCRIPTION (provided by applicant): The goal of these studies is to determine the efficacy of proprietary geranylgeranyl diphosphate synthase inhibitors (GGSIs), for inhibition of osteoclast mediated bone resorption in comparison to current standard-of-care agents. We have developed a group of proprietary bisphosphonates containing isoprene substructures that demonstrate highly potent and specifi ...

    SBIR Phase I 2013 Department of Health and Human Services
  3. Immunoassay for diagnosis of Babesia infection

    SBC: IMMUNETICS, INC.            Topic: NIAID

    DESCRIPTION (provided by applicant): This project is aimed at development of an enzyme immunoassay (EIA) for antibodies to Babesia for use as a clinical diagnostic test. Babesiosis is an emerging tick-borne parasitic disease which may cause severe to fatalillness in immunocompromised or otherwise weakened patients, and may be carried in the blood subclinically in up to 1% of the population in ende ...

    SBIR Phase I 2013 Department of Health and Human Services
  4. Aminoglycoside potentiators for P. aeruginosa therapy

    SBC: MICROBIOTIX, INC.            Topic: NIAID

    DESCRIPTION: Pseudomonas aeruginosa is a common cause of serious infections in patients with immune deficiency (e.g., HIV and cancer), cystic fibrosis (CF), on mechanical ventilation or with burn wounds. While P. aeruginosa exhibits an alarming variety ofintrinsic drug resistances, aminoglycosides (AMGs) such as tobramycin and amikacin, are still effective in treating diseases caused by this patho ...

    SBIR Phase I 2013 Department of Health and Human Services
  5. Medical Images, HTML5, and Clinical Trial Remote Collaboration

    SBC: MICROBIOTIX, INC.            Topic: NIAID

    DESCRIPTION: Pseudomonas aeruginosa is a common and extremely virulent cause of serious infections in immune- compromised/suppressed patients (e.g., HIV and cancer), cystic fibrosis patients, and those on mechanical ventilation or with burn wounds. Related clinically important Gram-negative [Gr(-)] nonfermenters include species of the genera Burkholderia, Acinetobacter, and Stenotrophomonas, whic ...

    SBIR Phase I 2013 Department of Health and Human Services
  6. RAPID AND SENSITIVE IDENTIFICATION OF HIV ANTIGEN AT THE POINT OF USE

    SBC: IMMUNETICS, INC.            Topic: NIAID

    DESCRIPTION (provided by applicant): HIV clade C, endemic in sub-Saharan Africa and the Indian subcontinent, is responsible for nearly half of all global HIV infections, and most large-scale HIV vaccine trials are targeted to clade C regions. Unfortunately, the development and trialing of candidate HIV vaccines brings with it the significant risk of vaccine-induced HIV seropositivity (VISP). VISP ...

    SBIR Phase I 2013 Department of Health and Human Services
  7. Healing of Diabetic Ulcers with Gaseous Nitric Oxide Generated from Room Air

    SBC: GLSynthesis Inc.            Topic: NIAMS

    DESCRIPTION: Androgen action is the net result of opposing pathways of steroid biosynthesis and metabolism. It is now widely recognized that testosterone (T) is an androgenic precursor of the more potent 5 -dihydrotestosterone (DHT), produced by 5 -reductase type 2. Circulating T and DHT also serve as precursors of estrogens through their conversion to estradiol and estrone by aromatase. Thus, re ...

    SBIR Phase I 2013 Department of Health and Human Services
  8. Development of a cationic contrast agent for targeted imaging of glycosaminoglyca

    SBC: IONIC PHARMACEUTICALS            Topic: NIAMS

    DESCRIPTION (provided by applicant): There is no known cure for Osteoarthritis (OA), a debilitating disease that afflicts 27 million people and costs 125 billion, annually. In OA, the articular cartilage is degraded and it has a limited capacity to self-heal; therefore, rendering a diagnosis at a late stage is ineffective at preventing further cartilage degeneration. Currently, there are no contr ...

    SBIR Phase I 2013 Department of Health and Human Services
  9. Targeting ATAP-mediated Apoptosis in Treatment of Prostate Cancer

    SBC: FLUIDIC TOOLS, LLC            Topic: NIAMS

    DESCRIPTION (provided by applicant): The lifetime of total joint replacement prostheses has been limited by three factors: oxidative degradation, wear and mechanical failure of its polyethylene components. In recent years, the problem of wear and oxidationresistance has been addressed. Radiation crosslinking substantially increases the resistance of polyethylene to particulate wear. Studies have s ...

    SBIR Phase I 2013 Department of Health and Human Services
  10. Biodegradable Drug-Eluting Surgical Meshes with Tunable Release Kinetics

    SBC: ACUITYBIO CORPORATION            Topic: NCI

    DESCRIPTION (provided by applicant): We have developed and are optimizing a prototype drug-eluting surgical mesh comprised of novel copolymer blends for controlled locoregional delivery of chemotherapy to prevent local colorectal tumor recurrence following surgical resection. Colorectal cancers are the third largest cancer killer in the US with the identificationof an estimated new 40,000 rectal ...

    SBIR Phase I 2013 Department of Health and Human Services

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