List

For best search results, use the search terms first and then apply the filters
Reset

The Award database is continually updated throughout the year. As a result, data for FY19 is not expected to be complete until April, 2020.

  1. New Subatmospheric MALDI MS Imaging Platform

    SBC: MASSTECH, INC.            Topic: 400

    The mass spectrometry imaging MSI is an important analytical technique broadly utilized to detect peptides lipids and small molecules in tissue samples with high spatial resolution It has been started to emerge as a reliable technique in a clinical environment particularly for characterization of drug distribution as well as morphological changes in tissues A proposed MSI platform will comb ...

    SBIR Phase I 2017 Department of Health and Human ServicesNational Institutes of Health
  2. Protein Engineering of a Biologic Drug Candidate

    SBC: Antidote Therapeutics, Inc.            Topic: NIDA

    Project Summary Abstract Cigarette smoking is responsible for nearly one half million deaths yr in the U S where direct healthcare costs to treat smoking and smoking attributable illness exceed $ billion year Only smokers achieve long term abstinence using standard of care pharmacotherapies leaving the majority still smoking and seeking alternatives The focus of this project is to ...

    SBIR Phase I 2017 Department of Health and Human ServicesNational Institutes of Health
  3. Development and Evaluation of Video Based Directly Observed Therapy for Office Based Treatment of Opioid Use Disorders with Buprenorphine

    SBC: Emocha Mobile Health Inc.            Topic: NIDA

    The Development and Evaluation of of Video Based Directly Observed Therapy for Office Based Treatment of Opioid Use Disorders with Buprenorphine is a project to develop a sustainable scalable and patient centered mobile health mHealth platform comprised of a patient facing mobile application and provider facing web portal for opioid use disorder treatment Methadone clinics are based on ...

    SBIR Phase I 2017 Department of Health and Human ServicesNational Institutes of Health
  4. A Circulating Biomarker for use in Monitoring Metastatic Breast Cancer

    SBC: A&G PHARMACEUTICAL, INC.            Topic: NCI

    Significance Despite decreases in the overall number of new breast cancer BC cases reported in the US annually there are still about BC deaths annually from metastatic breast cancer MBC Thus the ability to monitor MBC is important to determine disease status and therapy response While the gold standard imaging is expensive time consuming and slow to detect disease response o ...

    SBIR Phase I 2017 Department of Health and Human ServicesNational Institutes of Health
  5. Asynchronous Robotic Delivery for Better Logistics and Better Care

    SBC: Vecna Technologies, Inc.            Topic: 600

    An estimated of hospital budgets are spent on logistics activities such as moving medications supplies devices charts and surgical instruments through the supply chain to where they are needed at the point of care At the same time nurses are only able to spend approximately of their day on direct patient care due to non value added logistics and administrative responsibilities In ...

    SBIR Phase I 2017 Department of Health and Human ServicesNational Institutes of Health
  6. Novel Strategies to Improve Production of a Full Length Native HIV Env Spike

    SBC: CODEX BIOSOLUTIONS            Topic: R

    Project Summary Production of HIV envelope protein Env trimeric gp cleaved to gp gp for clinical studies is a critical objective for vaccine development Its conformational plasticity which allows it to adopt multiple conformational states important for function often makes its expression and purification very difficult Our recent work shows a route for overcoming this probl ...

    SBIR Phase I 2017 Department of Health and Human ServicesNational Institutes of Health
  7. Enhancement of Conditional Reprogramming Technology for Production of Functional Human Beta Cells

    SBC: Propagenix Inc            Topic: 200

    Project Abstract Insufficient supply of donor pancreatic islets to meet the demand for transplants severely limits therapeutic options for Type diabetic T D patients in whom insulin therapy is insufficient to control their disease And while there has been much recent success with the directed differentiation of human embryonic stem cells hu ESCs and human induced pluripotent stem cells hu ...

    SBIR Phase I 2017 Department of Health and Human ServicesNational Institutes of Health
  8. A Yeast based Immunotherapy against Clostridium difficile Infection

    SBC: FZATA INC            Topic: NIAID

    Abstract Antibacterial resistance is a global public health crisis Antibiotic resistant Clostridium difficile is responsible for more than deaths in US each year and the infection represents an urgent threat to public health worldwide Of most concern is that the incidence of C difficile infection CDI and disease severity is rapidly increasing in recent years due to the emergence of hy ...

    SBIR Phase I 2017 Department of Health and Human ServicesNational Institutes of Health
  9. Evaluation of Natural Products and Derivatives as Antimalarial Agents

    SBC: Cascade Therapeutics, Inc.            Topic: NIAID

    PROJECT SUMMARY The proposed research focuses on the development of novel therapeutic agents for the treatment of malaria caused by P falciparum Preliminary studies have discovered some novel natural products and derivative molecules with potent in vitro activity against both sensitive and multidrug resistant malaria strains including the newly emerging artemisinin resistant parasite line New ...

    SBIR Phase I 2017 Department of Health and Human ServicesNational Institutes of Health
  10. Point of care immunoassay for rapid diagnosis of tinea capitis

    SBC: DxDiscovery Incorporated            Topic: NIBIB

    Tinea capitis scalp ringworm is a fungal dermatophyte infection of scalp hair follicles that afflicts of the U S pediatric population Tinea capitis is a major health care disparity because it occurs predominantly among individuals with a disadvantaged socioeconomic background and sub Saharan African descent Diagnosis of tinea capitis is currently dependent on culture and microscopy Both ...

    SBIR Phase I 2016 Department of Health and Human ServicesNational Institutes of Health

Agency Micro-sites

SBA logo
Department of Agriculture logo
Department of Commerce logo
Department of Defense logo
Department of Education logo
Department of Energy logo
Department of Health and Human Services logo
Department of Homeland Security logo
Department of Transportation logo
Environmental Protection Agency logo
National Aeronautics and Space Administration logo
National Science Foundation logo
US Flag An Official Website of the United States Government