Award Data

Opioid use disorder (OUD) is highly prevalent among individuals with diagnosed anxiety disorders with more than 60% of individuals with OUD reporting a lifetime anxiety disorder. Co-occurring anxiety is linked to earlier and more rapid progression into OUD, poorer treatment outcomes, and high probability of co-use of other substances, particularly benzodiazepines (BZDs). BZDs are currently the sta ...

Summary/Abstract Among the most educationally valuable components of in-person 40-hour HAZMAT courses are team-based field exercises. This capstone activity combines skills and protocols into an experiential exercise in which learners practice different roles (e.g., entry team, decon team, site supervisor) and equipment (e.g., PPE, sensors, communications). Team-based HAZMAT training exercises hav ...

The US opioid crisis continues to have a catastrophic impact on human lives and the ongoing COVID-19 pandemic is compounding its effects. Based on the statistics published by the CDC, 91,799 drug overdose deaths occurred in the US in 2020, where the age-adjusted overdose deaths increased by 31% from 2019 to 2020. In addition, opioids, which cause respiratory depression, were involved in 75% of all ...

Abstract This Phase II SBIR will develop and demonstrate the efficacy of the Opioid Rapid Response System (ORRS) to improve responses to opioid overdoses. Opioid overdoses exact a tremendous cost in lives and expenditures. Naloxone has been developed to counteract overdoses; however, the nature of these events requires a rapid response, a situation that challenges emergency responders in both ligh ...

Project Summary/Abstract NeoTherma Oncology (NTO/www.neothermaoncology.com) has developed a novel non-invasive medical device that delivers mild hyperthermia (HT) loco-regionally as adjuvant therapy to standard of care treatment of abdominal deep-seated tumors. The VectRx™ device, designated “Breakthrough” by the FDA, has demonstrated its ability to safely heat abdominal organs (pancreas, li ...

It is estimated that approximately 5-10% of all diagnosed cancers are caused by Hereditary Cancer Syndromes (HCS) that are associated with germline mutations (inherited genetic mutations passed directly from a parent to a child that create a genetic predisposition to certain types of cancer). Recent epidemiologic models indicate that 1 in 279 people may be carriers of one of the most common HCS, a ...

7. Project Summary/AbstractC. difficile now causes more hospital-onset infections and deaths in the US than any other pathogen and is the most important cause of healthcare-associated diarrhea among adults in industrialized countries. In 2017, there were an estimated 462,100 combined healthcare- and community-associated C. difficile infection cases in the US, and 20,500 in-hospital deaths. In a ra ...

Abstract Regenerative medicine therapies of various kinds are promising and rapidly growing, both in scale and type. The therapeutic products are not pills–they are living cells that are harvested from a patient (or sometimes a cell bank) and are shipped to a pharmaceutical company that modifies the cells and then sends them back to be re- injected into the patient. Logistics plays an outsize r ...

Modern pharmaceuticals have greatly improved the quality of life for many patients suffering a variety of illnesses. Unfortunately, among the 17 most commonly prescribed drugs, only 6 are highly effective for most patients, 5 have a modest effect, and 6 show little clinical effect. Worse still, unwanted illness and death from treatment of patients with the incorrect drug or dosage causes over 275, ...

Project Summary: Self-developing, instant radiochromic films based on the solid-state polymerization of diacetylenes (R-C≡C-C≡C- R’, where R and R’ are substituent groups) are used for measuring radiation therapy dose. Currently available radiochromic films, e.g., the GafChromicTM EBT films from Ashland (Bridgewater, NJ, USA), have many drawbacks such as they are very expensive, sensitive ...