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THE LONG-TERM OBJECTIVE OF THIS PROJECT IS THE DEVELOPMENT OF IMPROVED NONISOTOPIC HOMOGENEOUS IMMUNOASSAYS. INITIALLY, A METHOD WILL BE DEVELOPED WHEREBY SULFHYDRL GROUPS WILL BE TRANSFERRED FROM AN ANTIGEN TO AN ANTIBODY SELECTIVELY NEAR THE LATTER'S ANTIGEN BINDING SITE. VARIOUSFLUORESCENCE OR ENZYME PROBES CAN THEN BE ATTACHED TO THE ANTIBODY AT THESE SITES. IN VIEW OF THE PROXIMITY OF ANTIGEN ...

THIS PROGRAM IS DESIGNED TO DEVELOP AN OUTLINE HPLC OR FIA ORGANOHALOGEN PHOTOELECTROANALYZER. MANY ORGANOHALOGENS HAVE BIOLOGICAL PROPERTIES, INCLUDING CARCINOGENESIS, MUTAGENESIS, AND/OR TERATOGENESIS. NEW AND IMPROVED METHODSOF TRACE ANALYSIS FOR SUCH COMPOUNDS WILL ASSIST THE REGULATORY AGENCIES, INDUSTRY, AND FEDERAL AND STATE GOVERNMENTS. USE OF SUCH AN ANALYTICAL APPROACH FOR ORGANOHALOGENS ...

A PROGRAM TO DEVELOP LASERS SUITABLE FOR IRRADIATING EXTERNALLY SUPPLIED CHROMOPHORES (DYES) IN TISSUE USING SELECTIVE PHOTOTHERMOLYSIS (SP) IS PROPOSED. SP ALLOWS PRECISE TARGET SPECIFICITY IN VIVO BY COLOR SELECTIVITY, AND SPATIAL SELECTIVITY DOES NOT DEPEND ON FOCUSING BUT INSTEAD DEPENDS ON TIME RESOLUTION. LARGE TISSUE VOLUMES CAN BE TREATED SIMULTANEOUSLY AND NON-TARGET TISSUE SPARED. THE LA ...

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THIS RESEARCH EXPLORES THE FEASIBILITY OF USING A NOVEL ELECTROCHEMICAL SENSOR FOR MONITORING THE ALCOHOL CONTENT IN BREATH. SUCCESSFUL DEMONSTRATION DURING THE PHASE I PROGRAM OF THE PROPOSED SENSOR'S RESPONSE, PRECISION, ACCURACY, DETECTIVITY, LIFE AND TOLERANCE TO INTERFERENCES WOULD LEAD TO A PHASE II PROGRAM TO DEVELOP A COMPUTERIZED INSTRUMENT FOR THE MEASUREMENT OF ALCOHOL TREATMENT COMPLIA ...

THE SPECIFIC AIM OF THIS PROJECT IS TO DEVELOP TECHNIQUES AND TOOLS TO CONVERT FORTRAN PACKAGES FROM ONE COMPUTER TO ANOTHER AND TO DEVELOP A PROTOTYPE OF SUCH A CONVERTER. THEIMMEDIATE APPLICATION OF THESE TECHNIQUES AND TOOLS IS THE CONVERSION OF THE NATIONAL CANCER INSTITUTE (NCI) DRUG INFORMATION SYSTEM (DIS) SOFTWARE PACKAGE FROM THE EXISTING 36-BIT COMPUTER ENVIRONMENT (DEC-10 SYSTEM) TO THE ...

EXPERIENCE WITH THE CLONING AND EXPRESSION OF CLONED GENES IN SACCHAROMYCES CEREVISIAE SUGGESTS THAT THE RECOVERED YIELD OF CORRECTLY FOLDED PROTEIN PRODUCT IS GREATLY IMPROVED BY THE USE OF A YEAST-SECRETION PROCESS. THIS IS ESPECIALLY TRUE FOR PROTEINS THAT ARE NORMALLY SECRETED FROMTHEIR NATURAL CELL SOURCES. THUS, COLLABORATIVE RESEARCH WILL FUSE THE GENE FOR HUMAN PROINSULIN TO A VARIETY OF Y ...

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