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The Award database is continually updated throughout the year. As a result, data for FY19 is not expected to be complete until April, 2020.

  1. Activate Silent and Cryptic Intact Fungal SM Gene Clusters through FACs for Novel Antibiotics Discovery

    SBC: Intact Genomics Inc.            Topic: NIAID

    DESCRIPTION provided by applicant There is societal need for new therapeutic agents in our arsenal of defenses against bacterial and fungal pathogens many of which are increasingly resistant to existing antibiotics Filamentous fungi are considered promising resources for the development of novel bioactive compounds because of their great potential to produce various kinds of secondary metabol ...

    SBIR Phase I 2015 Department of Health and Human ServicesNational Institutes of Health
  2. Therapeutic Role of Inter-alpha Inhibitors in Wound Healing

    SBC: PROTHERA BIOLOGICS, LLC            Topic: NIAMS

    DESCRIPTION provided by applicant Wound healing is an intricately regulated process broadly characterized by phases of inflammation proliferation and remodeling Imbalances in any one of these phases can result in inadequate healing scar formation or in the development of chronic wounds such as diabetic ulcers Diabetic ulcers are responsible for the majority of lower extremity amputations ...

    SBIR Phase I 2015 Department of Health and Human ServicesNational Institutes of Health
  3. A multi-analyte device for air quality monitoring

    SBC: TF HEALTH CORPORATION            Topic: NIEHS

    DESCRIPTION provided by applicant Air quality affects the health and well being of each of us especially those with chronic respiratory diseases Acute exposure to fatal levels of hazard materials causes millions of accidents every year and unnoticed long term exposure to lower levels of chemicals affect far more people Various technologies have been developed to monitor air quality but no ...

    SBIR Phase I 2015 Department of Health and Human ServicesNational Institutes of Health
  4. Optimized IL2-based Therapy for Type 1 Diabetes

    SBC: APT THERAPEUTICS, INC.            Topic: NIDDK

    DESCRIPTION provided by applicant Type diabetes is an immune mediated disease in which insulin producing beta cells are destroyed resulting in life long dependence on exogenous insulin The number of patients being diagnosed is increasing each year particularly in the very young Despite advances in glucose monitoring and insulin delivery there is a compelling need to identify therapies th ...

    SBIR Phase I 2015 Department of Health and Human ServicesNational Institutes of Health
  5. Novel, Ambulatory Cuff-less Non-invasive Arterial Blood Pressure Monitor

    SBC: Krisara Engineering            Topic: NHLBI

    DESCRIPTION provided by applicant The objective of this proposal is to complete the engineering development and testing of the Non Invasive Self calibrating Ambulatory Multi Modality NISAM blood pressure device to recognize hypertensive patients not currently identified using todayandapos s technology As well as providing better management of hypertensive patients by presenting a truer roun ...

    SBIR Phase I 2015 Department of Health and Human ServicesNational Institutes of Health
  6. Low-dose IL-2-based Immunomodulatory Therapy for PAH

    SBC: APT THERAPEUTICS, INC.            Topic: NHLBI

    DESCRIPTION provided by applicant Despite evidence that inflammatory mechanisms initiate and complicate pathophysiology in pulmonary arterial hypertension PAH no strategies have been developed to target the inflammatory cells involved Moreover it has been known for years that autoimmune diseases are associated with certain forms of PAH Hence novel therapy is urgently needed to attenuate ...

    SBIR Phase I 2015 Department of Health and Human ServicesNational Institutes of Health
  7. An Integrated Microarray Printing and Detection System

    SBC: BIOSENSING INSTRUMENT INC            Topic: 400

    DESCRIPTION provided by applicant Microarray technology has dramatically advanced the study of protein interactions leading to discovery and validation of new biomarkers and therapeutic drugs Typically protein microarrays are pre spotted with target molecules in one device and then tested with probe molecules using another device During each testing cycle the entire microarray becomes expos ...

    SBIR Phase I 2015 Department of Health and Human ServicesNational Institutes of Health
  8. Pre-IND study of PMT-254, a pan-FLT3 inhibitor for the treatment of FLT3 driven cancers.

    SBC: PROMUTECH PHARMACEUTICALS, INC.            Topic: 102

    DESCRIPTION provided by applicant Pathological activating mutations in the FLT kinase represent the most common genetic alteration in patients with acute myeloid leukemia AML occurring in approximately one third of cases Recently we performed translational studies that identified drug resistant kinase domain mutations in FLT ITD at the time of relapse in AML patients treated with the FLT ...

    STTR Phase I 2015 Department of Health and Human ServicesNational Institutes of Health
  9. Jerry the Bear: A Robotic Platform for At-Home Therapy and Education for Children with Type 1 Diabetes

    SBC: Sproutel            Topic: 200

    DESCRIPTION provided by applicant The goal of this SBIR Phase I application from Sproutel is to develop a curriculum for providing expert educational content on diabetes self management to be delivered via principles of game based learning in an appealing teddy bear robotic character designed for young children diagnosed with type diabetes mellitus Type diabetes T D affects approximately ...

    SBIR Phase I 2015 Department of Health and Human ServicesNational Institutes of Health
  10. Cellular Capacitance Monitoring Integration into Digital Patch Clamp Amplifier.

    SBC: ROKHAN LLC            Topic: 105

    DESCRIPTION provided by applicant Cell membrane capacitance is directly proportional to cell surface area This is true because membrane composition thickness and dielectric constant are invariant and not changed by differences in membrane protein density It is thus possible to monitor cellular capacitance fluctuations as a measure of cell surface area changes that occur with exo and endo c ...

    SBIR Phase I 2015 Department of Health and Human ServicesNational Institutes of Health

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