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The Award database is continually updated throughout the year. As a result, data for FY19 is not expected to be complete until April, 2020.

  1. CATHETERS

    SBC: Meridian Medical Corp.            Topic: N/A

    THE OBJECTIVE OF THIS PHASE I PROPOSAL IS TO ASSESS THE ACCURACY OF A NON-INVASIVE, ISOTHERMAL REBREATHING METHOD FOR MEASURING THE MIXED VENOUS PARTIAL PRESSURE OF HIGHLY SOLUBLE GASES. THIS APPROACH WILL ALLOW THE SEMI-INVASIVE (WITHOUT A PULMONARY CATHETER) MEASUREMENT OF THE VENTILATION/PERFUSION (VA/Q) DISTRIBUTION OF THE LUNG. DURING PHASE I, A PROTOTYPE DEVICE WILL BE DESIGNED, FABRI- CATED ...

    SBIR Phase I 1986 Department of Health and Human Services
  2. IN MAN

    SBC: Epoch Pharmaceuticals, Inc.            Topic: N/A

    IN THIS PROJECT, SYNTHETIC SHORT DNA PROBES WILL BE DEVELOPED FOR THE DIAGNOSIS OF SPECIFIC TYPES OF HUMAN PAPILLOMAVIRUS (HPV) INFECTIONS. SHORT DNA PROBES OF 20 TO 30 NUCLEOTIDES HAVE THE DESIRABLE PROPERTIES OF HIGH SPECIFICITY, FAST REACTION KINETICS, POTENTIAL HIGH SENSITIVITY, AND THE ABILITY TO BE SYNTHESIZED RAPIDLY IN LARGE AMOUNTS AT LOW COST. THEIR INHERENT HIGH SPECIFICITY IS AN IMPORT ...

    SBIR Phase I 1986 Department of Health and Human Services
  3. A DNA PROBE FOR THE DIAGNOSIS OF CAMPYLOBACTER PYLORIDIS GASTRITIS

    SBC: Epoch Pharmaceuticals, Inc.            Topic: N/A

    N/A

    SBIR Phase I 1986 Department of Health and Human Services
  4. DNA PROBES FOR THE DIAGNOSIS OF PERIODONTAL PATHOGENS

    SBC: Epoch Pharmaceuticals, Inc.            Topic: N/A

    N/A

    SBIR Phase I 1986 Department of Health and Human Services
  5. RADIOIODINATED CONJUGATES FOR THERAPY AND DIAGNOSIS

    SBC: NEORX CORPORATION            Topic: N/A

    THE PURPOSE OF THIS CONTRACT PROPOSAL IS TO DEVELOP NEW RADIOIODINE-LABELED CONJUGATES FOR MONOCLONAL ANTIBODIES THAT CAN BE USED IN DIAGNOSIS AND THERAPY OF CANCER. THE GOAL OF OUR PROPOSED RESEARCH IS TO INVESTIGATE A NOVEL METHOD OF INTRODUCING HIGH SPECIFIC ACTIVITY RADIOIODINE INTO SOME SMALL MOLECULES WHICH CAN BE CONJUGATED TO MONOCLONAL ANTIBODIES. OUR APPROACH TO DEVELOP NEW CONJUGATES IS ...

    SBIR Phase II 1986 Department of Health and Human Services
  6. RADIORHENIUM ANTIBODIES FOR RADIOIMMUNOTHERAPY

    SBC: NEORX CORPORATION            Topic: N/A

    THE OBJECTIVE OF THIS PHASE I SBIR PROJECT IS TO DEVELOP A RE-186 AGENT SUITABLE FOR LABELING BIFUNCTIONAL CHELATING AGENT ANTIBODY CONJUGATES. ALTHOUGH CHEMICALLY SIMILAR TO TC-99M, APPLICATION OF RE-186 TO YIELD POTENTIAL THERAPEUTIC RADIOPHARMACEUTICALS PRESENTS PROBLEMS WHICH HAVE YET TO BE SOLVED. SPECIFICALLY, IT IS MUCH MORE DIFFICULT TO MAINTAIN RE IN REDUCED OXIDATION STATES THAN TC, AND ...

    SBIR Phase II 1986 Department of Health and Human Services
  7. THE PURPOSE OF THIS PROJECT IS TO LABEL MONOCLONAL ANTIBODIES WITH ASTATINE-211 FOR USE IN RADIO-IMMUNOTHERAPY.

    SBC: NEORX CORPORATION            Topic: N/A

    THE PURPOSE OF THIS PROJECT IS TO LABEL MONOCLONAL ANTIBODIES WITH ASTATINE-211 FOR USE IN RADIO-IMMUNOTHERAPY.THE GOAL OF THE PROPOSED RESEARCH IS TO DEVELOP A METHOD TO INCORPORATE ASTATINE INTO ANTIBODIES SUCH THAT THE ASTATINE LABILE IN VITRO OR IN VIVO. IN THE INVESTIGATION, TWO DIFFERENT APPROACHES TO LABELING WILL BE COMPARED. ONE APPROACH WILL BE DIRECT LABELING WITH ASTATINE; THE OTHER AP ...

    SBIR Phase I 1986 Department of Health and Human Services
  8. THE OBJECTIVE OF THIS PHASE I PROJECT IS TO DEVELOP AND EVALUATE A NOVEL METHOD FOR RADIOLABELING MONOCLONAL ANTI- BODIES WITH TECHNETIUM-99M FOR THE SPECIFIC DIAGNOSIS OF CANCER.

    SBC: NEORX CORPORATION            Topic: N/A

    THE OBJECTIVE OF THIS PHASE I PROJECT IS TO DEVELOP AND EVALUATE A NOVEL METHOD FOR RADIOLABELING MONOCLONAL ANTI- BODIES WITH TECHNETIUM-99M FOR THE SPECIFIC DIAGNOSIS OF CANCER. THE METHOD PROVIDES FOR A VERY EFFICIENT UPTAKE OF OFFERED TECHNETIUM TO THE HIGH SPECIFIC ACTIVITY REQUIRED FOR RADIOIMAGING. ANTIBODY PREPARED ACCORDING TO THE DESCRIBED METHOD RETAINS MOST OF ITS IMMUNOREACTIVITY, AND ...

    SBIR Phase I 1986 Department of Health and Human Services
  9. RHENIUM-188 HAS FAVORABLE PHYSICAL PROPERTIES AS A THERA- PEUTIC RADIONUCLIDE, T-1/2 OF 17.

    SBC: NEORX CORPORATION            Topic: N/A

    RHENIUM-188 HAS FAVORABLE PHYSICAL PROPERTIES AS A THERA- PEUTIC RADIONUCLIDE, T-1/2 OF 17.0 HOURS, EMAX BETA 2.2 MEV,AND EGAMMA 155 KEV. METHODOLOGY HAS BEEN DEVELOPED FOR CONJUGATION OF RHENIUM IN STABLE COMPLEXED FORM TO ANTIBODIES. THE OBJECTIVE OF THIS PROPOSAL IS TO DEVELOP THE TECHNOLOGY NECESSARY TO MAKE HIGH SPECIFIC ACTIVITY RE- 188 AVAILABLE FOR RADIOIMMUNOTHERAPY USING THE W-188/RE-188 ...

    SBIR Phase I 1986 Department of Health and Human Services
  10. PURIFICATION OF MARINE OIL-DERIVED POLYUNSATURATES

    SBC: Ocean Organics Inc.            Topic: N/A

    N/A

    SBIR Phase I 1986 Department of Health and Human Services

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