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The Award database is continually updated throughout the year. As a result, data for FY19 is not expected to be complete until April, 2020.

  1. Electronic Optimization of Stem Cell Derived Human Cardiac Myocytes

    SBC: Cytocybernetics Inc            Topic: NHLBI

    DESCRIPTION provided by applicant As part of the FDA approval process for novel therapeutic drugs safety screening demonstrating that the new drug does not have deleterious effects on the human cardiac action potential is required Healthy human heart cells are not available for such preclinical drug testing There is currently no consensus on the best experimental approach to provide the most ...

    STTR Phase I 2015 Department of Health and Human ServicesNational Institutes of Health
  2. Evaluation of TRB-N0224, a Proprietary Chemically Modified Curcumin, for the Treatment of Periodontal Disease in a LPS-Induced Rat Model

    SBC: TRAVERSE BIOSCIENCES, INC.            Topic: NIDCR

    DESCRIPTION provided by applicant Traverse Biosciences Inc is a pre clinical stage drug development company working to commercialize new chemical entities which act to resolve inflammatory conditions through pleiotropic host modulation of pathologically unrestrained matrix metalloproteinases MMPs and pro inflammatory cytokines The companyandapos s lead drug candidate TRB N is a propri ...

    STTR Phase I 2015 Department of Health and Human ServicesNational Institutes of Health
  3. Development of a high-throughput assay for measuring m6A demethylase activity

    SBC: Base5 Biosciences Inc            Topic: NIDA

    DESCRIPTION provided by applicant N methyladenosine m A was recently discovered to be a widespread base modification present in thousands of mammalian mRNAs In addition to its prevalence throughout the transcriptome researchers have also revealed that m A is a reversible modification suggesting that dynamic regulation of mRNA methylation is a novel and widespread RNA regulatory mechanism ...

    STTR Phase I 2015 Department of Health and Human ServicesNational Institutes of Health
  4. Technology-Guided Opioid Cessation for Post-Operative Pain

    SBC: MedicaSafe Inc            Topic: R41

    DESCRIPTION provided by applicant This STTR application proposes development of MedicaSafe Inc andapos s Multimodal Analgesic Protection System MAPSafe Built around MedicaSafeandapos s proprietary Medication Therapy Optimization MTO technology MAPSafe will be designed to mitigate the myriad risks associated with prescription opioid use post operatively and throughout recovery after surge ...

    STTR Phase I 2015 Department of Health and Human ServicesNational Institutes of Health
  5. Biological treatment of bacterial keratitis

    SBC: AMEBAGONE, INC.            Topic: N

    DESCRIPTION provided by applicant Staphylococcus is the most common cause of infections worldwide The pathogen persists asymptomatically on human skin from which it may spread to ocular tissues and cause corneal infection When this happens corneal bacterial keratitis can occur and if not treated effectively it may lead to blindness Multi Drug Resistant MDR variants of S aureus Sa are ...

    STTR Phase I 2015 Department of Health and Human ServicesNational Institutes of Health
  6. Mass Spectrometric Screening of the Effect of Chemical Toxicants on the Human Epitranscriptome during Stem Cell Differentiation

    SBC: ATHGHIN BIOTECHNOLOGY, INC.            Topic: 113

    DESCRIPTION provided by applicant Epitranscriptomics explores levels and evolution of RNA modifications as a response from intra and inter cellular stimuli These modifications and the levels at which they are present are emerging as important regulators of biological processes Perturbations such as chemical toxicants exposure can alter the patterns of specific modifications on RNA sub types ...

    STTR Phase I 2015 Department of Health and Human ServicesNational Institutes of Health
  7. The Development of a High-Throughput Assay to Screen Chemical Compounds in Human Pluripotent Stem Cell Derived Neural Cells

    SBC: ATHGHIN BIOTECHNOLOGY, INC.            Topic: 113

    DESCRIPTION provided by applicant The long term objective of this application is to provide a high throughput platform to test the effects of chemical exposure on human brain development In the US chemicals are not required for health or environmental safety testing before their incorporation in consumer products Over registered chemicals are in commerce most of which are used withou ...

    STTR Phase I 2015 Department of Health and Human ServicesNational Institutes of Health
  8. Clinical Translation of an Anti-Metastatic Antibody for Breast Cancer Therapy

    SBC: FOR-ROBIN, INC.            Topic: 102

    DESCRIPTION provided by applicant Translational studies are proposed to support the continued development of the JAA F antibody based therapy to address the critical need for a safe and effective treatment for metastatic breast cancer including triple negative breast cancers Building on the success of our Phase I project the overarching objectives of the Phase II application are to advanc ...

    STTR Phase II 2015 Department of Health and Human Services
  9. Calibrated Methods for Quantitative PET/CT Imaging Phase II

    SBC: Kitware, Inc.            Topic: 102

    DESCRIPTION provided by applicant The overall goal of this Phase II STTR proposal is to develop a PET CT imaging tool that will help accelerate the development of effective cancer therapies by improving the utility of oncology trials using PET imaging The growing cost time and complexity of clinical trials are driving patient and pharmaceutical company demand for more objective efficient a ...

    STTR Phase II 2015 Department of Health and Human Services
  10. Neuroimaging tools for presurgical brain mapping

    SBC: PRISM CLINICAL IMAGING, INC.            Topic: 102

    DESCRIPTION provided by applicant The goal of this project is to develop functional magnetic resonance imaging fMRI tools to assist the diagnosis and treatment of human patients with a brain tumor or other operable pathology The specific focus of this proposal is to produce a practical clinic ready suite of MR imaging methods analyses and display tools to solve the number one impediment to ...

    STTR Phase II 2015 Department of Health and Human ServicesNational Institutes of Health

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