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The Award database is continually updated throughout the year. As a result, data for FY24 is not expected to be complete until March, 2025.

Download all SBIR.gov award data either with award abstracts (290MB) or without award abstracts (65MB). A data dictionary and additional information is located on the Data Resource Page. Files are refreshed monthly.

The SBIR.gov award data files now contain the required fields to calculate award timeliness for individual awards or for an agency or branch. Additional information on calculating award timeliness is available on the Data Resource Page.

  1. Enhancement of the Beneficial Effects of Mesenchymal Stem Cell (MSC) Treatment by the Caveolin-1 Scaffolding Domain Peptide (CSD)

    SBC: LUNG THERAPEUTICS INC            Topic: NHLBI

    Abstract Systemic sclerosissclerodermaSScis a chronic connective tissue disease in which lung fibrosis is the most frequent cause of deathSSc and idiopathic pulmonary fibrosis are the two most common disease that falls under the interstitial lung diseasesILDa grouping of devastating diseases in which lung fibrosis leads to progressive shortness of breatha very poor quality of lifeand death within ...

    STTR Phase I 2018 Department of Health and Human ServicesNational Institutes of Health
  2. Novel Immuno-oncology Strategy for Targeted Cytotoxic Lymphocyte Activation

    SBC: Courier Therapeutics Inc            Topic: 102

    PROJECT SUMMARY ABSTRACT Systemic administration of high dose ILhas been used since thes as an FDA approved immunotherapy for metastatic cancerDespite the fact that up toof patients treated with high dose ILachieve a durablelong term responsethis therapy is rarely used today due to significant life threatening complicationsSuch complications occur due to ILactivation of vascular endotheliumresulti ...

    STTR Phase I 2018 Department of Health and Human ServicesNational Institutes of Health
  3. Lightweight and long lasting battery technology for Left Ventricular Assist Devices LVADs

    SBC: LYNNTECH INC.            Topic: NHLBI

    PROJECT SUMMARY Heart failure is a leading cause of mortality throughout the worldThe only viable life sustaining option for patients with advanced heart failure is a heart transplantDue to the complex nature of the heart transplant procedure and the limited supply of donor heartsmost of these patients tend to use Left Ventricular Assist DevicesLVADseither to bridge the gap until they can undergo ...

    SBIR Phase I 2018 Department of Health and Human ServicesNational Institutes of Health
  4. Novel treatment for DIC

    SBC: A2 Therapeutics Inc.            Topic: NHLBI

    Project Summary Several diseasesincluding endotoxemiaand sepsis can cause disseminated intravascular coagulationDICDIC can induce the formation of microvascular thrombicausing organ failure and death in the absence of the appropriate treatmentTo datethere are no drugs to treat DICand several reagents have been tested buttheir strong doses can lead to severe bleedingsignificantly diminishing their ...

    STTR Phase I 2018 Department of Health and Human ServicesNational Institutes of Health
  5. Optimization of a Novel Thread Geometry for Various Orthopaedic Surgery Applications

    SBC: OSTEOCENTRIC TECHNOLOGIES INC            Topic: NIAMS

    PROJECT SUMMARY ABSTRACTAmong the multiplicity of thread shapesthe buttress thread design remains the historic paradigm for the shape of current orthopedic screwsThe popularity of buttress threads in current orthopedic screw designs is reflected by the advantage of handling high axial thrust in one directionwhich leads to increased shear strength and improved unidirectional pullout resistance comp ...

    SBIR Phase I 2018 Department of Health and Human ServicesNational Institutes of Health
  6. A Reliable Switched Angle Spinning (SAS) Probe with Gradients (PFG) for Proteins in Solid-State NMR

    SBC: DOTY SCIENTIFIC, INC.            Topic: 400

    A Reliable Switched Angle SpinningSASProbe with GradientsPFGfor Proteins in Solid State NMR AbstractSolid state NMRssNMRbiotechnology is emerging as an alternative method of choice for highresolution structure determination for integral membrane proteinsIMPsssNMR provides a unique platform to investigate protein dynamicsand functional studies of wide range of biomolecules in their supramolecular a ...

    SBIR Phase I 2018 Department of Health and Human ServicesNational Institutes of Health
  7. Pediatric Implantable Low-Shear Pulsatile Blood Pump with Physiologic Sensing and Control

    SBC: WINDMILL CARDIOVASCULAR            Topic: NHLBI

    Project SummaryAbstract The goal of this project is to develop high level physiological controlimprove low level dynamic piston controland develop hemodynamic sensing capabilities for the pediatric TORVADTMa unique ventricular assist system that delivers low shearsynchronouspulsatile flowusing controlled piston motion within a torus shaped pumping chamberThe pediatric TORVAD is intended for patien ...

    SBIR Phase I 2018 Department of Health and Human ServicesNational Institutes of Health
  8. Overcoming anti-PD-1 resistance by systemic delivery of an oncolytic adenovirus that targets TGF-beta

    SBC: Multivir Inc.            Topic: 102

    Project Summary The overall goal of this proposal is to test a novel systemic Adenoviral therapy that targets transforming growth factorTGFand reverses anti PDresistance to treat advanced breast and lung cancersThis STTR grant application illustrates the synergistic relationship between DrPrem Sethinventor of a novel TGFdecoyand MultiVir Inca leader in clinical development of gene based therapeuti ...

    STTR Phase I 2018 Department of Health and Human ServicesNational Institutes of Health
  9. I-Corps Program Application for Market Assessment of Non-invasive Imaging Device to Improve Outcomes of Amputations Surgery in Critical Limb Ischemia.

    SBC: Spectral Md, Inc.            Topic: NHLBI

    Executive Summary Nearlypatients in the US undergo lower extremity amputations annually secondary to peripheral arterial diseasePADcomplicated by critical limb ischemiaCLITo increase a patient s post operative quality of lifesurgeons attempt to salvage as much limb tissue as possible while also considering the likelihood of primary wound healing at a given level of amputationLOAThe principal chall ...

    SBIR Phase I 2018 Department of Health and Human ServicesNational Institutes of Health
  10. Quantitative Analysis of Single Molecule Microscopy

    SBC: Astero Technologies LLC            Topic: 400

    PROJECT SUMMARY ABSTRACTSingle molecule microscopy is a relatively novel technique that allows individual molecules to be imaged using the optical microscopeIt is of major interest to scientists because it enables the observation of cellular processes at the molecular levela task that is not achievable with classical optical imaging approaches due to the cellular processes being obscured by averag ...

    SBIR Phase II 2018 Department of Health and Human ServicesNational Institutes of Health
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