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The Award database is continually updated throughout the year. As a result, data for FY24 is not expected to be complete until March, 2025.

Download all SBIR.gov award data either with award abstracts (290MB) or without award abstracts (65MB). A data dictionary and additional information is located on the Data Resource Page. Files are refreshed monthly.

The SBIR.gov award data files now contain the required fields to calculate award timeliness for individual awards or for an agency or branch. Additional information on calculating award timeliness is available on the Data Resource Page.

Displaying 31 - 40 of 5129 results
  1. Multispectral Sensor for Chemical Composition Analysis of Ultrafine Aerosols in Air Quality Assessment

    SBC: SPECTREE INC.            Topic: R

    Project SummaryWe propose developing and validating a novel platform technology that combines the collection and chemical analysis of ultrafine particles using an in-situ multispectral technique. The sample, collected directly onto the analysis substrate, is analyzed via excitation-emission matrix (EEM) spectroscopy. This approach will be validated against laboratory combustion-generated aerosols, ...

    STTR Phase II 2023 Department of Health and Human ServicesNational Institutes of Health
  2. iKinnect Mobile Technology to Reduce Teen Substance Misuse and Health Disparities

    SBC: EVIDENCE-BASED PRACTICE INSTITUTE, INC.            Topic: NIDA

    PROJECT SUMMARY/ABSTRACTAdolescent substance abuse (SA) has been called America’s #1 public health problem, affecting as many as 16% of all youth under age 18 and often resulting in serious consequences such as criminal involvement, health problems, and suicide. Given that adolescent SA is associated with high rates of comorbidity with mental health (MH) problems and increased suicide risk, inte ...

    SBIR Phase I 2023 Department of Health and Human ServicesNational Institutes of Health
  3. Microscope system for large scale optical imaging of neuronal activity using kilohertz frame rates

    SBC: MICROBRIGHTFIELD, LLC            Topic: 105

    Abstract This project aims to develop the 2P-ActivityScope™, a revolutionary new microscope based on a technological breakthrough called second-generation Scanned Line Angular Projection (SLAP2) two photon laser scanning microscopy that was recently developed by Dr. Kaspar Podgorski (Janelia Research Campus, Howard Hughes Medical Institute, Ashburn, VA). The game-changing innovation in the 2P-Ac ...

    SBIR Phase II 2023 Department of Health and Human ServicesNational Institutes of Health
  4. Multiplexed biosensor for personal wildfire exposure assessment

    SBC: DL ADV-TECH, LLC            Topic: R

    Summary/Abstract: Wildfire are becoming more frequently and severe due to climate change, resulting in growing exposures of major population to high level of benzene and polycyclic aromatic hydrocarbons from biomass-burning emissions. Wildfire exposure pose a serious threat to the health and the well-being of humans. Currently, assessment of personal exposure to wildfire is dependent on taking env ...

    SBIR Phase I 2023 Department of Health and Human ServicesNational Institutes of Health
  5. Deep learning methods to accelerate discoveryof drugs targeting gene regulatory proteins

    SBC: TALUS BIOSCIENCE INC            Topic: 400

    SUMMARY To evaluate how a drug candidate affects cells, researchers often study how the abundance or behavior of a specific set of proteins is changed by treatment with each compound. However, it is not currently possible to test the effect of every possible drug compound (rt500,000) on every human protein (~20,000) in hundreds of different types of cells. Even the most advanced protein analysis s ...

    SBIR Phase I 2023 Department of Health and Human ServicesNational Institutes of Health
  6. Activity-based regulome profiling for the discovery of covalent transcription factor inhibitors

    SBC: TALUS BIOSCIENCE INC            Topic: 100

    RESEARCH SUMMARY The human genome encodes more than 1,600 transcription factors (TFs), along with additional cofactors, chromatin regulators, and structural proteins that collectively execute the regulatory instructions encoded within the nuclear DNA. Dysfunctions of these proteins are known to drive multiple diseases such as cancer, inflammation-related, and neurological conditions. In cancer, th ...

    SBIR Phase I 2023 Department of Health and Human ServicesNational Institutes of Health
  7. LIGHTSITE IIIB: Clinical Evaluation of Photobiomodulation (PBM) in dry AMD Patients

    SBC: LUMITHERA INC            Topic: NEI

    ABSTRACT As the population continues to age, degenerative ocular diseases become increasingly common and create tremendous burden on the health care system. Age-related macular degeneration (AMD) is a progressive ocular disease that causes visual impairment and blindness in its most advanced form and is characterized by loss of function and cell death in the macula, a central and critical part of ...

    SBIR Phase II 2023 Department of Health and Human ServicesNational Institutes of Health
  8. Remmie.ai: a deep learning diagnostic assistance engine for ear-nose-throat diseases

    SBC: REMMIE INC            Topic: NIDCD

    PROJECT SUMMARY Otitis media (OM) is experienced by five out of six children before their third birthday, and 30-40% suffer recurring infections, leading to 16 million annual episodes in the US. Ear infections are the primary reason for antibiotic prescription for children under 6 years, are the second most common cause of hearing loss, and can lead to lifelong sequelae. Diagnosis depends upon in- ...

    SBIR Phase I 2023 Department of Health and Human ServicesNational Institutes of Health
  9. Development of a Universal Assay for Minimal Residual Disease in Acute Myeloid Leukemia using Duplex Sequencing

    SBC: TWINSTRAND BIOSCIENCES INC            Topic: NCI

    Problem: With a 5-year survival of ~30%, AML is the 6th deadliest cancer, and rt20,000 new patients are diagnosed each year in the United States. Although most patients achieve Complete Remission (CR) with aggressive therapy, most will eventually relapse. The criteria for CR, however, is based on historical diagnostic methods, and patients in CR may carry up to 1010 residual leukemia blasts. Signi ...

    SBIR Phase II 2023 Department of Health and Human ServicesNational Institutes of Health
  10. A Phase 2, Single-Arm Study of the CXCR1/2 Inhibitor SX-682 Plus Enzalutamide in Men with Abiraterone-Resistant Metastatic Castration Resistant Prostate Cancer (mCRPC)

    SBC: Syntrix Biosystems, Inc.            Topic: 102

    Prostate cancer (PC) is the second leading cause of cancer-related death among American men, and the vast majority of these deaths are due to metastatic, castration-resistant PC (mCRPC). Androgen suppression therapy (AST) is used to treat PC patients, which comprise of: (1) androgen deprivation therapy (ADT) with LHRH agonists or antagonists; (2) blocking CYP17-mediated androgen synthesis with abi ...

    SBIR Phase I 2023 Department of Health and Human ServicesNational Institutes of Health
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