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SBC: VIROGENOMICS BIODEVELOPMENT INC Topic: R41
Methamphetamine use disorder is associated with damage to regions of the brain that control cognitive and psychiatric functionOne third to one half of adults with methamphetamine use disorder experience cognitive impairments and other psychiatric symptoms that significantly impact treatment outcomesincreased relapse and lower treatment retention ratesMounting evidence demonstrates how immune facto ...STTR Phase I 2019 Department of Health and Human ServicesNational Institutes of Health
SBC: ARCHIE MD INC. Topic: DHA17A002
Providing Army combat medics with meaningful experience in treatment of battlefield injuries is a particular challenge. Moulage has the potential to assist in acquiring what could otherwise be very hard-to-come-by preparatory experience for distressing real-life emergencies medics and soldiers may encounter in the field. However, current approaches to moulage are limited in their ability to reflec ...STTR Phase II 2018 Department of DefenseDefense Health Agency
SBC: CONVERGENT ENGINEERING, INC. Topic: NICHD
DESCRIPTION (provided by applicant): Preeclampsia, a hypertensive disorder of pregnancy, is a leading cause of maternal and neonatal morbidity and mortality around the world, responsible for approximately 76,000 maternal and 500,000 infant deaths per year.As a heterogeneous and poorly understood disorder, its pathogenesis and possible treatments are an area of active research. While the majority o ...STTR Phase I 2013 Department of Health and Human ServicesNational Institutes of Health
SBC: INVENUX, LLC Topic: NCCAM
DESCRIPTION: New therapeutic agents are urgently needed for the treatment of sickle cell disease (SCD), the world's most common genetic disease. Our long-term goal is to develop a drug for use in children that prevents the inexorable progression of SCD. SCD affects approximately 100,000 people in the United States and millions worldwide. It kills more children in Africa than HIV, but while HI ...STTR Phase I 2013 Department of Health and Human ServicesNational Institutes of Health
SBC: COLUMBUS NANOWORKS, INC. Topic: 400
Fluorescent nanodiamonds are biocompatibleinfinitely photostableand fluoresce in a variety of wavelengthsincluding the near infraredNIRregionThese characteristics suggest transformative applications in areas ranging from pure biological research to biomedical imagingwhere protein conjugated nanodiamonds could be targeted to specific tissues in living patients or even structures within individual c ...STTR Phase I 2018 Department of Health and Human ServicesNational Institutes of Health
SBC: ZENAGENE, INC. Topic: NCI
DESCRIPTION (provided by applicant): While there is no doubt smoking is a direct causative factor underlying the development of lung cancer, not every smoker develops lung cancer. In fact, only 10-15% of smokers develop this disease, indicating that otherfactors make certain individuals more susceptible to cancer. A number of single nucleotide polymorphisms are known to correlate with the developm ...STTR Phase I 2013 Department of Health and Human ServicesNational Institutes of Health
SBC: Oncoimmune Inc Topic: 100
Project Summary AbstractThe recent rapid expansion of genomic data greatly contributes to the understanding of disease development and progressionTo translate these genetic discoveries into clinical applicationswe need to develop therapeutic platforms that can specifically modulate the expression of disease related genes in vivoSmall RNAssuch as microRNAs and siRNAs function in messenger RNA silen ...STTR Phase I 2019 Department of Health and Human ServicesNational Institutes of Health
Evolution of an Adaptable Prosthetic Foot Design for Normalization of Biomechanics During Community ParticipationSBC: OHIO WILLOW WOOD COMPANY, THE Topic: NICHD
Evolution of an Adaptable Prosthetic Foot Design for Normalization ofBiomechanics During Community Participation Summary/AbstractThe vision of this project is to improve the functional physical mobility of people with lower extremity amputations especially on uneven ground, side-slopes or when foot placement varies from side-to-side. People with amputations will be enabled to confidently participa ...STTR Phase II 2019 Department of Health and Human ServicesNational Institutes of Health
Extending WAAVES+: An animal and environment-agnostic, automated USV scoring platform for high-throughput social, behavioral, and neuropharmacological studiesSBC: CORNERSTONE RESEARCH GROUP INC Topic: 101
Project SummaryUltrasonic vocalizations (USVs) are known to reflect emotional processing, brain neurochemistry and brain function - key observations in animal model studies. Collecting and processing USV data is time-intensive, manual, and costly. Most importantly, it limits researchers’ ability to employ fully effective, and nuanced experimental designs, and is a barrier to entry for other rese ...STTR Phase I 2019 Department of Health and Human ServicesNational Institutes of Health
SBC: iXpressGenes, Inc. Topic: NIGMS
DESCRIPTION (provided by applicant): Crystallization, followed by subsequent structure determination, is a major step in understanding the structure-function relationship of macromolecules. Understanding macromolecule structure has become a key part in the development of new pharmaceuticals, and is a major area of NIH research. Crystallization however is also the rate limiting step, despite techn ...STTR Phase I 2010 Department of Health and Human ServicesNational Institutes of Health