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A New Non-Invasive Approach for Accessing Pulmonary Arterial Stiffness in Patients with Pulmonary HypertensionSBC: ARCUS-MED LLC Topic: NHLBI
Pulmonary hypertensionPHis a disease affecting approximatelyof the general population that is characterized by abnormally elevated mean pulmonary artery pressuremPAPand pulmonary vascular resistancePVRIf left untreatedPH can ultimately lead to right heart failure and deathCurrent diagnostic approaches utilize invasive right heart catheterizationRHCto measure mPAP and PVREarly detection of PH leads ...STTR Phase I 2019 Department of Health and Human ServicesNational Institutes of Health
Extending WAAVES+: An animal and environment-agnostic, automated USV scoring platform for high-throughput social, behavioral, and neuropharmacological studiesSBC: CORNERSTONE RESEARCH GROUP INC Topic: 101
Project SummaryUltrasonic vocalizations (USVs) are known to reflect emotional processing, brain neurochemistry and brain function - key observations in animal model studies. Collecting and processing USV data is time-intensive, manual, and costly. Most importantly, it limits researchers’ ability to employ fully effective, and nuanced experimental designs, and is a barrier to entry for other rese ...STTR Phase I 2019 Department of Health and Human ServicesNational Institutes of Health
SBC: Periomics Care LLC Topic: NIDCR
Abstract Periodontitis is a common chronic inflammatory disease characterized by destruction of the supporting structures of the teeththe periodontal ligament and alveolar boneThe total prevalence of periodontitis in adults agedyears and older wasrepresenting aboutmillion adults agedyears and olderandin adults agedyears and older in the U SEpidemiological data confirm that diabetes is a major risk ...STTR Phase I 2019 Department of Health and Human ServicesNational Institutes of Health
SBC: DynamiCare Health, Inc Topic: NIDA
ABSTRACT Opioid overdose is a major public health crisisand a clear sign of problem drug useMany people who experience an overdose receive a naloxone reversal and are treated in a hospital emergency departmentHoweverfew overdose survivors enroll in treatmenteven if they receive care and referral to treatment while in an emergency departmentMedication assisted treatmentsMATsuch as methadone or bupr ...STTR Phase I 2019 Department of Health and Human ServicesNational Institutes of Health
SBC: VOX BIOMEDICAL LLC Topic: NIDA
Project Summary This proposal seeks to expand upon breath analysis technology that is being actively studied as the focus of NIH grant #6R42DA049655-02 and leverage this technology for rapid COVID-19 diagnostics. There is a dire need for sensitive and specific diagnostic tests for COVID-19 that can be performed quickly. The differential mobility spectrometry (DMS) breath analysis technology curren ...STTR Phase I 2019 Department of Health and Human ServicesNational Institutes of Health
Development of a Wearable Fluorescence Imaging Device for Intraoperative Identification of Brain TumorsSBC: BIOPTICS TECHNOLOGY LLC Topic: 102
ABSTRACTApproximatelypeople in the United States have been diagnosed with a primary brain tumorOf thesemalignant gliomasMGsaccount for approximatelyof all intracranial tumorswith an overall patient survival rate of onlyMore than any other cancerbrain cancer has lasting physicalcognitiveand psychological impacts on a patient s lifeand the highest per patient initial cost of careSurgical resection r ...STTR Phase I 2019 Department of Health and Human ServicesNational Institutes of Health
SBC: Technology Commercialization Partners LLC Topic: OD
PROJECT SUMMARYABSTRACT To datethe standard method to access a mouse tail vein is manual injectionbut its yield rate is poor in generalThis leads to multiple needle insertions associated with tissue damage and painBesidesfailure in tail vein injection leads to data lossand thereby more animals will be required to compensate itFinallythe dose variation induced by unreliable injection increases erro ...STTR Phase I 2019 Department of Health and Human ServicesNational Institutes of Health
A portable multi-parametric optical spectroscopy device for key vascular and metabolic endpoints monitoring in small animalsSBC: Zenalux Biomedical, Inc. Topic: OD
Altered vascularity and deregulated metabolism are two important cancer hallmarksInterest in therapeutically exploiting these functional endpoints continues to growsince metabolism and vasculature significantly impact a tumor s fateThere is growing demand for systems level technologies that measure tumor metabolism within an intact microenvironment to inform strategies to prevent resistancerecurre ...STTR Phase I 2019 Department of Health and Human ServicesNational Institutes of Health
SBC: CFD RESEARCH CORPORATION Topic: DHA19A001
Traumatic injuries account for 30% of all life years lost in the US and is the leading cause of death for people under 46 years of age. Uncontrolled bleeding or hemorrhage constitute 30-40% of trauma related deaths and are considered to be a major cause oSTTR Phase I 2019 Department of DefenseDefense Health Agency
SBC: MAKScientific, LLC Topic: 400
RESEARCH andampRELATEDUnitPROJECT SUMMARY ABSTRACT In response to PAthe aim of this Phase I STTR proposal is to optimize and develop peripherally actingcannabinoidreceptorCB Rneutral antagonists displaying favorable therapeutic profiles for treating diabetic nephropathyDNDN is a chronic diabetic kidney disease and affectstypeand typediabetic patientsIt is characterized by persistent albuminuria an ...STTR Phase I 2019 Department of Health and Human ServicesNational Institutes of Health