Award Data

In the proposed SBIR project Akita Innovations and Adaptive 3D will develop feedstock materials and methods for the additive manufacture of soft elastomers that exhibit resistance to the permeation of chemical agents.The goal of the effort is to produce a fully functional Air Purifying Respirator (APR) and to demonstrate advantages of additive manufacturing to provide innovations such as custom si ...

Researchers are identifying new biomarkers to help monitor cognition and stress in the human body and enhance human performance.Traditional biomarkers like heart rate, temperature, oxygen partial pressure, blood glucose, electrolyte concentration, and others have beencorrelated with cognition and stress states. However, the correlation is indirect. Molecular biomarkers with stronger and more speci ...

The consequence of physical and mental degraded performance is of critical importance not only to the Department of Defense (DoD) missions and sports persons, but also to the general population as well. Sweat is an information abundant medium that contains biomarkers that show relation to human cognitive levels. However, obtaining days of continuous sampling of sweat from the same dermal spot has ...

There is an urgent need to bypass or cross the blood brain barrier (BBB) to deliver drugs for TBI treatment. This project aims to develop targted intranasally delivered, magnetically propulsed, and targted nanoparticles for traumatic brain injury (TBI). In Phase I, we will demonstrate the design, fabrication, and in vitro characterization of proposed drug laden magnetic nanoparticles as well as co ...

Triton proposes to develop and demonstrate a comprehensive solution for in-ear monitoring of noise exposure and auditory function that can be used in lieu of standard hearing protection for Service Members engaged in operational tasks to provide a better understanding of the relationship between noise exposures and hearing injury and better protect warfighter hearing.

We have identified NSI-566, a stable neural stem cell line, isolated and expanded from a single human fetal spinal cord tissue, as the investigational product for TBI treatment.NSI-566 has been approved by the US FDA as an investigational product for clinical testing in ALS (IND# 13905) and chronic SCI (IND# 14413) which are ongoing.For TBI treatment, we propose to place deposits of NSI-566 into t ...

Pain is a serious and widespread problem over the short-term for wounded military personnel in the battlefield and over the long-term for veterans. Military pain management strategies for acute and chronic pain are increasingly multimodal, combining pharmacological and nonpharmacological interventions. Timely management of acute pain improves the outcomes both in the short- and long-term and preve ...

The Defense Health Agency is interested in alternative, non-opiate methods of pain control for wounded servicemen. One potential solution is the use of short duration, high voltage pulses (generally referred to as nanosecond Electric Pulse, or nsEP) to disrupt neural transmission from a wound to the central nervous system.The basic nsEP process is similar to electroporation in Pulsed Electric Fiel ...

This project addresses the need for a compact loudspeaker array to test spatial hearing in audiometric sound booths. Spatial hearing tests, especially tests of sound localization and spatial unmasking of speech reception, are needed both for qualifying prospective equipment and for assessing fitness for duty of military personnel. Work in Phase I will address the acoustic issues that arise from ha ...

While clinical audiometry is most often conducted with headphones, there are many practical cases where it is desirable to measure the free-space hearing performance of both normal-hearing listeners and listeners wearing hearing aids, hearing protection devices, or implantable hearing prosthetics, both for evaluating fitness for duty and for evaluating outcomes of clinical interventions. Tradition ...