Award Data

Falls are a significant source of early morbidity and mortality in the aging population, yet the neurological,sensory, and motor changes that lead to increased fall risk often escape early identification and intervention. Vital signs are commonly used in clinical settings to assess the cardiovascular system (blood pressure, heart rate), immune system (body temperature), and the respiratory system ...

Glioblastoma (GBM) is the most lethal form of adult brain cancers with a median survival of andlt;15 months despite aggressive standard chemoradiation. GBM are formed by GBM stem-like cells (GSCs) - a major contributor to tumor recurrence and a natural focus for therapeutic development. There are two main reasons responsible for treatment failure: 1) high intra- and inter-tumor cellular and molecu ...

Optical photothermal IR (OPTIR) microscopy for chemical imaging of living cells at sub-micron resolution Project Summary/Abstract Photothermal Spectroscopy Corp (PSC) and Prof. Ji-Xin Cheng of Boston University in collaboration with Prof. Rohith Reddy (University of Houston) propose to develop, validate, and commercialize a novel technical called Optical Photothermal Infrared (OPTIR) spectroscopy. ...

This proposal is for a phase I/II fast track project for the STTR program with the main goal to develop a test for high sensitive detection of tau oligomers in biological fluids, which could be used for the biochemical diagnosis of Alzheimer’s disease (AD) and related tauopathies. AD is the most common dementia in the elderly population and one of the leading causes of death in the developed wor ...

Through the execution of our Phase 1 effort, Nutronics, Inc. and Montana State University developed an improved means to optimize the Pellizzarri cost functional for coherent imaging using digital holography. Our algorithm developed during the Phase 1 effort accelerates convergence times by a factor of 20-40 for the majority of scenarios evaluated. Our proposed Phase 2 effort has a two-fold focus: ...

The Phase II effort will be to clearly demonstrate the feasibility and build a prototype of a noncontact, high-quality holographic polarimetry system with pixel level depth and Mueller matrix information with a user-friendly interface to image and display this data. The measurements of each data product will be validated with trusted truth samples. The system will be reproducible and will have a d ...

The Biomagnetics Micro Dosimetry System (BMDS) program will design, model, and simulate a microdosimetry system that can measure and create a three dimensional map of weak radiofrequency signals in biological organisms. The heart of the BMDS project is the front end that delivers very sensitive, broad band measurements with high spatial resolution. The front end is a valuable tool in the investiga ...

This Phase II project aims to assemble the key set of sensor modalities that are needed to reliably view the key process anomalies and properties of laser powder bed fusion. The research team will down-select from the Phase I sensors investigated and integrate the sensors into a sensor fusion software package that facilitates data collection and synchronization, and eventually feedback control of ...

Replacement of petroleum based vehicles with fuel cell electric vehicles operating on hydrogen produced from domestically available resources would dramatically decrease emissions of greenhouse gases and other pollutants as well as reduce dependence on oil from politically volatile regions of the world. One major inhibitor to a hydrogen society is the lack of infrastructure, which requires hydroge ...

In order to make large scale commercial production of microalgae based commodity food and fuel products, significant strides in algal productivity need to be achieved. With current regulatory guidelines, large scale outdoor cultivation of microalgae for these products restricts the use of transgenic algal strains, which in the laboratory thus far have been the primary strategy taken to effectively ...