Award Data

The broader impact of this Small Business Technology Transfer (STTR) Phase I project will be to improve solid organ transplantation outcomes. Few significant clinical or technological advancements have been made within the last two decades to improve orga

PROJECT SUMMARY The ability of dying cells to activate antigen presenting cells (APCs) is carefully controlled to avoid unwarranted inflammatory responses. Thus, tumor cells avoid aggravating APCs by efficiently simulating regular dying cells which following phagocytosis do not trigger inflammatory responses required for efficient cytotoxic T lymphocyte (CTL) priming. However, dying tumor cells co ...

Project Summary/Abstract Chronic lymphocytic leukemia (CLL) is the most prevalent adult leukemia in Western countries. Despite recent treatment advances, CLL remains incurable. In the era of emerging targeted therapies, disease progression and relapse increasingly are key challenges faced by CLL patients. Therefore, there is an ongoing need for the identification of targetable vulnerabilities in t ...

Project Summary Prostate cancer is one of the most commonly occurring forms of cancer, accounting for 21% of all cancer in men. The Prostate Imaging Reporting and Data System (PI-RADS) aims to standardize reporting of prostate cancer using multi-parametric magnetic resonance imaging (mpMRI). However, the in-depth analysis, as demanded by PI-RADS, remains challenging due to the complexity and heter ...

The broader impact/commercial impact of this Small Business Technology Transfer (STTR) Phase I project is to proactively manage eye health. Approximately 285 million people and 39 million people suffer respectively from visual impairment and blindness. Monitoring of eye disease in early stages is critical to slowing its progression, but currently this assessment requires specialized equipment in o ...

The broader impact of this Small Business Technology Transfer (STTR) Phase I project is to provide waste concrete as a new raw material source for the glass and other industries. It is estimated that 2.2 billion tons of waste concrete is generated globally each year. About 70% of the construction waste generated in the US is concrete, but it is not typically used as a raw material for glass produc ...

The development of a VCSEL capable of 100Gbps NRZ signaling over the temperature range of -40 to +85C with photonic resonant enhancement of the modulation bandwidth using photonic crystal coupling is proposed. A revolutionary change to the recent evolutionary progress in high speed VCSEL operation is needed to make the leap from 25Gbps devices to ones capable of delivering the > 60GHz bandwidth ne ...

This project uses two new vertical-cavity surface-emitting laser (VCSEL) designs along with a commercialization route to develop 100 Gb/s serial data rate transceiver capability. The designs include oxide and oxide-free VCSELs with reduced electrical resistance and capacitance to reach small signal bandwidth > 50 GHz. The oxide-free VCSEL approach has demonstrated increased reliability in high st ...

There is critical need for therapeutic delivery devices that can be administered intravenously (IV), and effectively home to and deliver therapeutic agents to diseased tissues, while maintaining patient safety. Cytonus Therapeutics, in collaboration with UC San Diegoandapos;s Moores Cancer Center, has pioneered a unique, drug transporter system with potential to treat to a wide range of cancers in ...

In recent years vertical-cavity surface-emitting lasers (VCSELs) have been deployed aside semiconductor diode lasers as the sources in cost-effective fiber links and data center networks  due to their distinct features, such as high reliability, low cost and high yield, low power consumption and easy packaging; low threshold and operating currents, high temperature stability and straightforward f ...