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The Award database is continually updated throughout the year. As a result, data for FY19 is not expected to be complete until April, 2020.

  1. Device for Surgical Adhesion Prevention

    SBC: Novelmed Therapeutics Inc            Topic: NIGMS

    DESCRIPTION (provided by applicant): Postoperative adhesion formation is the single greatest complication of surgery. Twenty seven million surgical procedures are performed annually in the U.S. where the patient is at risk for the complications from surgical adhesions. After surgery, fibrous adhesions form in the peritoneum, central nervous system, pericardium, pleura and synovium. Fibrous adhesio ...

    SBIR Phase I 2010 Department of Health and Human Services
  2. Controlling Inflammation Due to Cardiac Devices

    SBC: Novelmed Therapeutics Inc            Topic: NHLBI

    DESCRIPTION (provided by applicant): NovelMed's lead drug candidate prevents biomaterials induced cellular activation. Activated cells release inflammatory mediators that are responsible for pathological trauma that leads to cardiac, lung, liver, and brain injuries during surgical procedures that require cardiac devices. Our findings provide convincing support for developing YalcixiMab as a treatm ...

    SBIR Phase I 2010 Department of Health and Human Services
  3. Neutralizing Antibodies for Complement Inhibition

    SBC: Novelmed Therapeutics Inc            Topic: NIAID

    DESCRIPTION (provided by applicant): Ischemia-reperfusion (I/R) injury is a common clinical event, which has the potential to seriously affect, and sometimes result in death, of the patient. Interruption of the blood supply causes ischemia, which rapidly damages metabolically active tissues. Paradoxically, restoration of blood flow to the ischemic tissues initiates a cascade of pathology that lead ...

    SBIR Phase I 2010 Department of Health and Human Services
  4. Inhibition of Cardiac Device Induced Cellular Dysfunction in Pigs

    SBC: Novelmed Therapeutics Inc            Topic: NHLBI

    DESCRIPTION (provided by applicant): Artificial surfaces of cardiac devices induce cellular activation and platelet dysfunction in patients undergoing bypass procedure. While other pathways may be activated during this process, alternative pathway (AP) activation appears to be one of the important mechanisms for cellular activation and platelet dysfunction in the whole blood model of biomaterial s ...

    SBIR Phase I 2010 Department of Health and Human Services
  5. Disease Modifying Biologics for Rheumatoid Arthritis

    SBC: Novelmed Therapeutics Inc            Topic: NIA

    DESCRIPTION (provided by applicant): Nearly 70 million people in the US suffer from arthritis related conditions[1, 2]. Of these, rheumatoid arthritis (RA) cases constitute approximately 3 million. RA is a chronic systemic inflammatory disease that primarily results in erosive destruction of articular joints with additional variable extra-articular effects. The growing elderly population coupl ...

    SBIR Phase I 2010 Department of Health and Human Services
  6. Injectable collagen crosslink augmentation for degenerative disc disease

    SBC: ORTHOPEUTICS, LP            Topic: NIAMS

    DESCRIPTION (provided by applicant): With regard to prevalence and cost to society, low-back pain has few peers. With a patient population in excess of 15 million/year, the societal cost is estimated to be in the realm of 100 billion/year. Current treatment options for this disease have shown limited success, including physical therapy, medication and surgery. This proposal involves a novel, nons ...

    SBIR Phase II 2010 Department of Health and Human Services
  7. Y2 and Y4 Agonists in Obesity

    SBC: P2D, INC            Topic: NIDDK

    DESCRIPTION (provided by applicant): The purpose of the proposed studies is to assess the feasibility of developing a novel Neuropeptide Y (NPY) obesity treatment. Extensive preclinical and clinical studies indicate that NPY receptors are important mediators of appetite and obesity. The proposed Specific Aims will determine if chronic treatment with selective NPY Y2 or Y4 receptor agonists demonst ...

    SBIR Phase I 2010 Department of Health and Human Services
  8. PD2024: A Peripherally Active TNFalpha inhibitor for the treatment of Obesity

    SBC: P2D, INC            Topic: NIDDK

    DESCRIPTION (provided by applicant): The purpose of the proposed SBIR Phase 1 feasibility study is to assess the efficacy of our lead tumor necrosis factor- alpha (TNF1) inhibitor for the treatment of obesity. Two-thirds of U.S. adults are obese or overweight according to NIH statistics published in 2006. In addition to increased mortality observed in obesity, it is estimated that 70% of cardiovas ...

    SBIR Phase I 2010 Department of Health and Human Services
  9. A non-surgical embryo transfer device for producing gene modified rats

    SBC: PARATECHS CORP.            Topic: NCRR

    DESCRIPTION (provided by applicant): Rats represent the most commonly used physiologically and pharmacological experimental model for studying human disease. The ability to genetically modify rats through methods of gene transfer in fertilized rat embryos or by gene targeting in embryonic stem (ES) cells has significantly increased the capabilities of rats in biomedical and pharmaceutical research ...

    SBIR Phase I 2010 Department of Health and Human Services
  10. Novel methods for improving virion production in baculovirus

    SBC: PARATECHS CORP.            Topic: NIGMS

    DESCRIPTION (provided by applicant): Baculovirus expression vectors have been successfully used to produce thousands of proteins for vaccines, therapeutics, and structure-function studies. Baculoviruses have also been adapted for use as mammalian expression systems and potential gene therapy agents. This proposal explores a novel strategy for purification, quantitation, and storage of high titer b ...

    SBIR Phase I 2010 Department of Health and Human Services

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