Award Data

Abstract Periodontitis is a common chronic inflammatory disease characterized by destruction of the supporting structures of the teeththe periodontal ligament and alveolar boneThe total prevalence of periodontitis in adults agedyears and older wasrepresenting aboutmillion adults agedyears and olderandin adults agedyears and older in the U SEpidemiological data confirm that diabetes is a major risk ...

DESCRIPTION (provided by applicant): Asthma is a very common lung condition in children, and incidence is increasing in the US particularly in urban and minority populations. The standard of care for asthmatics is inhaled steroid, although clinical response is variable. The mechanism of efficacy of steroids in asthma is thought to be via anti-inflammatory pathways, although other anti-inflammatory ...

Sensor networks embedded on structures, such as pipes, bridges, railways, aircraft wings and fuselage, among others, are required to transfer data related to the health of the structure. This data is typically sent to a central location where it can be processed, displayed, and analyzed. Typical Structural Health Monitoring (SHM) uses embedded ultrasonic transducers exclusively for non-destructive ...

The metabolic syndrome (MetS) is a cluster of factors that increases the risks for cardiovascular disease, type 2 diabetes mellitus, and mortality, and currently affects andgt; 40% of US adults. MetS is associated with endothelial dysfunction, decreased circulating endothelial progenitor cells (EPCs), and a pro-inflammatory state. We have made the exciting discovery that therapy with allogeneic me ...

A spacecraft thermal control system must keep the vehicle, avionics and atmosphere (if crewed) within a defined temperature range. Since water is non-toxic and good for heat transport, it is typically used as the coolant that circulates within the crew cabin boundary. This loop then interfaces with another low freeze point fluid, such as ammonia, for transport of heat to a radiator where the tempe ...

DESCRIPTION (provided by applicant): The goal of this project is to synthesize, based on genomic sequence information, a human cytomegalovirus (HCMV) strain with demonstrated ability to establish persistent infection in sero-positive individuals. The resulting synthetic product will form the basis for the development of attenuated HCMV vaccines. Innovative synthetic biology methods will overcome ...

Vescent Photonics and MIT Lincoln Labs (MIT-LL) propose to develop a quantum-based vector magnetometer with low size, weight, power, and cost (SWaP+C) for Navy applications. The proposed system will rely on probing magnetically-sensitive, atomic-like transitions of nitrogen-vacancy (NV) centers in diamond to provide stable, high-bandwidth readout of the vector magnetic field with sub-picotesla sen ...

ABSTRACT: The damage and loss caused by attacks and security breaches have drawn attentions to develop secure and reliable systems for embedded systems. Compared to their desktop counterparts, embedded devices are facing more security challenges, such as the more possible physical access to a target device and more constrained computing environment (e.g., limited RAM and CPU power). Together, the ...

Genome-scale predictable cellular design and engineering of biomanufacturing systems is the overarching a goal of DARPA's Living Foundry thrust and, if realized, will enable rapid engineering of living biosystems for a broad range of applications in biotechnology and pharmacology. However, constructing living cells with designed genome is not fully automated and is severely limited by inhere ...

The objective of the proposed research is to develop a portable, passive system for rapid and efficient blood component separation. While a number of macro-scale devices are routinely employed in laboratory settings to separate, for example, red blood cells (RBCs) from platelet-rich plasma (PRP), and an emerging class of microfabricated devices are slowly being developed to address various low-th ...