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The Award database is continually updated throughout the year. As a result, data for FY19 is not expected to be complete until April, 2020.

  1. Mighty Girls and the Mighty Moment App:Leveraging Innovative Technology, Narrative Theory, and Social Media to Empower Young Girls to Resist Peer Pressure to Engage in Risky Behavior

    SBC: Real Prevention LLC            Topic: 600

    The goal of this SBIR Phase I is to prevent risky sexual behaviors among young female adolescents in order to reduce negative outcomes such as early pregnancy and sexually transmitted infectionsTo accomplish this goalwe propose using state of the art technology to develop a scalable and multicultural version of the efficacious Mighty Girls program and evaluate its usability and feasibilityEarly se ...

    SBIR Phase I 2019 Department of Health and Human ServicesNational Institutes of Health
  2. Multifunctional Semi-Powered Ankle Prosthesis: Phase II

    SBC: Synchro Motion LLC            Topic: NICHD

    PROJECT SUMMARY A conventional prosthetic ankle consists of a carbon fiber ankle foot complex that is nominally configured to a neutral positionThese prostheses generally work well for level walking and level ground standingbut lack the adaptability to explicitly accommodate other terrain or locomotion activitiessuch as slope walkingslope standingand stair ambulationAs suchcommon activities with a ...

    SBIR Phase II 2019 Department of Health and Human ServicesNational Institutes of Health
  3. Expanding the throughput of real-time toxicological screening of cardiac differentiation by expressing a synthetic luciferase/luciferin genetic pathway in iPSCs

    SBC: 490 BIOTECH INC            Topic: NIEHS

    Expanding the throughput of real time toxicological screening of cardiac differentiation byexpressing a synthetic luciferase luciferin genetic pathway in iPSCs Project Summary This Small Business Innovation ResearchSBIRPhase II project proposes to develop and validate autonomously bioluminescent induced pluripotent stem cellsiPSCsfor use in continuously data producingreagent freeand real time toxi ...

    SBIR Phase II 2019 Department of Health and Human ServicesNational Institutes of Health
  4. "Dusquetide for the treatment of oral mucositis in the pediatric population"

    SBC: Soligenix, Inc            Topic: NIDCR

    Project Summary Abstract This proposal requests funding to support the conduct of the juvenile toxicology study of SGXdusquetidethe first step of embarking on a larger SGXpediatric development programThe major objectives of the study are to confirm the safety of SGXin a juvenile population and to facilitate a safety study in a pediatric patient population at high risk of developing severe oral muc ...

    SBIR Phase I 2019 Department of Health and Human ServicesNational Institutes of Health
  5. Soft Tissue Characterization in Urogynecological Surgery

    SBC: Advanced Tactile Imaging, Inc.            Topic: NIBIB

    Project Summary Laparoscopic surgeryreferred to as minimally invasive surgeryis a surgical technique in which operations in the abdominal or pelvic cavities are performed through smallmmincisionsIt is now considered the standard of care for many procedures on female pelvic floor which account for approximatelymillion cases per year in the U SThe laparoscopic technique includes traditional minimall ...

    SBIR Phase I 2019 Department of Health and Human ServicesNational Institutes of Health
  6. Mobile-phone integrated rapid diagnostic tests to improve antibiotic stewardship

    SBC: PragmaDx, Inc.            Topic: NIAID

    PROJECT SUMMARYAn estimatedbillion antibiotic prescriptions were filled in the US fromDespite a national antibiotic education campaignapproximatelyof antibiotic prescriptions are unnecessaryAs a result of the over prescription of antibioticsthere is a current and pressing public health need for improved antibiotic stewardshipCompounding this problem are new modalities of healthcare like telemedici ...

    STTR Phase I 2019 Department of Health and Human ServicesNational Institutes of Health
  7. Telerehabilitation Combining Virtual Reality Adaptable Games and Drug Therapy for Early Alzheimer's Disease

    SBC: Bright Cloud International Corp            Topic: NIA

    PROJECT SUMMARY ObjectivesThe first objective is to develop a computer based cognitive training system for individuals in the early stages of Alzheimer s DiseaseThe producta home based custom Virtual RealityVRsystem will be developedtargeting cognitive domainsprocessing speedexecutive functionsattentionlanguagememoryas well as depressionThe system will incorporate a novel low cost biosensor device ...

    SBIR Phase I 2019 Department of Health and Human ServicesNational Institutes of Health
  8. Denaturation-Free DNA Target Enrichment and Direct Sequencing of Large Chromosomal Segments

    SBC: GENERATION BIOTECH, LLC            Topic: 172

    SummaryThird generationlong read sequencing technologies are increasingly sought after for the analysis of difficult genomic regionssuch as the major histocompatibility complexMHCthe human leukocyte antigenHLAloci and genomes of cancerspathogens and viral insertionsas well as plant and animal genomesSuch methods provide researchers with more contextual informationenabling analysis of highly comple ...

    SBIR Phase I 2019 Department of Health and Human ServicesNational Institutes of Health
  9. Micronized salsalate in a parenteral formulation is a safe and effective analgesic for acute postoperative pain management

    SBC: RH NANOPHARMACEUTICALS L.L.C.            Topic: 102

    SUMMARYThe White House has initiated an aggressive campaign to combat the current opioid crisis that is affecting all levels of the American way of lifeThe opioid crisis has emerged from multiple frontsAmong these various frontsthe continued use of opioids in the post operative area is a growing addiction riskCurrent postoperative pain management utilizes a multimodal pain management strategywhich ...

    SBIR Phase I 2019 Department of Health and Human ServicesNational Institutes of Health
  10. PreImplantation Factor plus hypothermia to treat neonatal brain injury

    SBC: BioIncept, LLC            Topic: NICHD

    ABSTRACTPerinatal hypoxic ischemic encephalopathyHIEaffectstoinfants per everybornMortality from HIE can be up toand approximatelyof survivors suffer significant longterm disability including cerebral palsyepilepsyand developmental disordersDamage during the acute phase of HIE is caused by a deficit in oxygen and glucose in the brainHoweverincreasing evidence indicates that secondary and tertiary ...

    STTR Phase I 2019 Department of Health and Human ServicesNational Institutes of Health

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