Award Data

The need for a rapid, reliable needle free delivery system for Hu BCHE bioscavengers is identified. The critical medical and design issues involved are presented. A needle free jet injection system is detailed. The Phase I effort comprises detailedpharmacokinetic studies and preliminary and detailed device design. The fabrication of a size appropriate injector for test rodents will also be underta ...

Surfaces Research proposes development of an innovative new extreme-temperature engine lubricant. We propose a high-temperature multicylinder engine test of the lubricant in a Surfaces Research engine operating at Future Combat System (FCS) conditions. Thenew lubricant has exceedingly long useful life at high temperature, outstanding resistance to high-temperature deposit formation, and unparallel ...

DESCRIPTION (provided by applicant): Isoprenoid diphoshates are key metabolic intermediates for the biosynthesis of many classes of molecules required by single and multicellular organisms. They fulfill a wide variety of cellular functions: components of cell membranes (sterols), electron transport (ubiquinones), signal transduction (prenylated proteins), and cell wall biosynthesis (dolichols)-ess ...

DESCRIPTION (provided by applicant): Isoprenoid compounds form a large ubiquitous class of natural products that fulfill a wide variety of essential cellular functions in all living organisms. In eukaryotes, isoprenoid compounds are synthesized by a mevalonate (MVA) dependent pathway. However, in many bacteria, these compounds are synthesized by an alternative, MVA-independent route whose first ...

DESCRIPTION (provided by applicant): Phosphoinositide recognition by binding proteins and lipid-metabolizing enzymes involves specific interactions with the head group and diacylglycerol backbone, which vary significantly from protein to protein. When a fluorescent probe is introduced into the inositol head group, binding and metabolism are severely attenuated or abrogated entirely. When a fluores ...

DESCRIPTION (provided by applicant): The purpose of this Phase I project is to test the feasibility of using an interactive multimedia (IM) format for delivering professional development to adults tutors and paraprofessionals who work with students with LD and low achievement. To evaluate the feasibility of this type of instruction current professional development materials for training tutors and ...

DESCRIPTION (provided by applicant): Phospholipids (PL) including phosphoinositides (PIPn) are crucial structural and signaling molecules for proper inter- and intra-cellular communication in an organism. The disruption of lipid homeostasis is associated with numerous human pathologies. High levels of LPA, LPC, PI (3,4,5) P3, PI (3) P and PI (4,5) P2 are linked to specific pathologies such as c ...

DESCRIPTION (provided by applicant): The purpose of this Phase I project is to test the feasibility of using an interactive multimedia format for instructing students with learning disabilities in writing strategies. To evaluate the feasibility of this type of instruction, an instructional program for teaching four punctuation rules and the strategies associated with those rules will be designed a ...

This Small Business Innovation Research Phase I project will yield a new heat flow or differential temperature sensing technology that will fundamentally improve micro-calorimeters and other instruments that depend on temperature measurement or control. The activity will complete the detailed design and fabrication of a new type of heat flow sensor having 10 to 100 times greater sensitivity than ...

72102S03-I In order to comply with current EPA regulations for reducing the level of sulfur in gasoline and diesel fuel, domestic refineries will need to install new process units for desulfurization of the fuel streams. However, current commercially available desulfurization technologies have significant energy requirements due to the severe operating conditions (such as high temperatures and p ...