Award Data

DESCRIPTION (provided by applicant): Recent tragedies at the Sago Mine, the Aracoma Alma Mine No. 1, and the Darby Mine No. 1 have focused renewed attention on an old problem: situational awareness in mine emergencies. Improved communication is a partial, but not complete, solution to the problem. Mine emergencies often involve dense smoke and dust that impair visibility and disorient even those ...

Razor Technologies proposes to develop and demonstrate a total hypergolic propellant (both fuel & oxidizer) leak detection system. Long life, small, low power consumption, inexpensive, conducting polymer sensors for the measurement of fuel and oxidizer concentrations have been successfully demonstrated in Phase I of this project. The proposed Phase II research will further optimize and refine th ...

DESCRIPTION (provided by applicant): In children with acute lymphomatic leukemia (ALL) and in myelodysplastic syndrome (MDS) with older patients it is extremely important to measure the minimal residual disease (MRD) to monitor the progress of chemotherapy at early stages Such measurements determine the prognosis, efficacy, and levels of the treatment. The normal method for detection and monitori ...

DESCRIPTION (provided by applicant): This Phase II program intends to continue to develop an improved brachytherapy delivery system for treatment of lung cancer by incorporating radioactive 169Ytterbium sources into surgical staples used in lung resect ion. For patients with compromised cardiopulmonary status, the inclusion of brachytherapy with sublobular resection has shown a significant imp ...

Accurate geometric and mathematical modeling of three-dimensional object shapes is a critical component of a variety of applications, ranging from design and manufacturing, to modeling and simulation. The models used in these applications may be created using interactive Computer Aided Design (CAD) tools, by hand-editing geometry configuration files, as the outputs of automated systems such as las ...

DESCRIPTION (provided by applicant): Improved understanding of the role of growth factors as biochemical mediators of wound healing has paved the way for a new family of bioactive therapeutic products to expedite wound healing. Delivery of growth factors ( recombinant or as autologous platelets) has emerged as a possible commercial opportunity for improving the clinical outcomes of soft, bone, and ...

This Phase II proposal describes a Trusted Radar concept, which is an innovative concept developed by Torch Technologies to support a key BMDS C2BMC function called Sensor Registration Health & Status Monitoring (SRHSM). The Trusted Radar concept is designed to address the significant problems associated with relying on High Accuracy Ephemeris (HAE) satellites as reference targets for performing ...

DESCRIPTION (provided by applicant): The aim of this proposal is to develop an effective and rapid method for disrupting the poultry-to-human transmission of avian influenza by in ovo injection of adenovirus-vectored avian influenza vaccines that can be ma ss-produced in cultured cells and mass-administered with a mechanized injector. The hypothesis is that mass-vaccination of poultry against an o ...

DESCRIPTION (provided by applicant): Studies of the molecular mechanisms underlying neoplastic transformation and progression have resulted in the understanding that cancer is a genetic disease, deriving from the accumulation of a series of acquired genet ic lesions. Despite advances in chemotherapy, radiation delivery, and surgical treatment regimens, survival from many advanced cancers remains ...

DESCRIPTION (provided by applicant): The principal objective is to demonstrate clinically a commercially viable, low-cost, high-resolution fundus camera that: is easy to use, i.e., consistent with the operation of current fundus cameras; has a field of vie w (FOV) that is typical of current fundus cameras (15 to 30 degrees); has a factor of five or more improvement in resolution as compared to exi ...