Award Data

Linear regulators are widely used for providing stable voltage supplies. When a regulator provides a voltage signal to a capacitive device, the quiescent current can be designed in submicron amperes. This low quiescent current attribute will be employed to build low power high-voltage amplifiers and applied for developing two application specific integrated circuits (ASICs) in this proposal. Each ...

NASA requests a high spatial-resolution, wide-area scan of lunar soil composition, especially within impact craters, that may contain a higher concentration of usable material such as 3He and H2O. Soil with a higher hydrogen content will tend to slow down (i.e., thermalize) neutrons rather than absorb them, thereby depressing the fast and epithermal components of the neutron energy distribution wh ...

We aim to develop an electrical-sensor to detect low-levels of Lactic Acid Bacteria (LAB) in yeastinocula used to start large-scale ethanol cultures reducing the loss of productivity of the culture andthe incidence of "stuck" fermentations [Topic-Area 8.8: Biofuels and Bio-based products whereinwe will be "developing new and improved technologies that will lead to improvedcompetitiveness"]Currentl ...

An existing problem being faced in the development of new vaccines is the need for targeting bacterial infections that occur at mucosal sites such as the upper airway and the gastrointestinal tractOvercoming this problem will require the use of novel vaccine formulations andin particularthe use of novel immune enhancing agentsadjuvantsthat promote immune responses that are effective at mucosal sit ...

The goal of this Phase I SBIR project is to develop a scalable method of Cpurification for use in Creplacement therapy based on a novel immunoaffinity chromatography resinDeficiency of complement CC Dis reported to be the most common hereditary defect among complement components with a prevalence ofPatients with homozygous complete deficiency suffer from recurring pyrogenic infections with encapsu ...

Project SummaryAbstractEpilepsy affects approximatelyof the world populationtotaling andgtmillion patientsWhile anti epileptic drugAEDtreatment is successful in many patientsof patients continue to experience seizures causing physicians to adjust change medications or other treatment parametersCurrent diagnostic tools are incapable of differentiating between patients experiencing a recent seizure ...

ABSTRACT The long term goal of this project is the commercial development of a low cost Single Molecule SequencingSMStechnologycalled Exo Seqwhich employs a sequencing by subtraction strategy for high fidelity disassembly of low amounts of unamplified DNAsIn spite of the SMS approachExo Seq possesses superior single pass base call accuracyandgtusing a multiparameter identification strategy that ta ...

AbstractThrombosis affectstopatients in the United States annuallyand results in more thandeaths each yearRapid and complete removal of blood clots to re canalize blood vessels is criticalThe goal of this study is to develop a high efficient endovascular method to remove blood clots by combining laser and ultrasound techniquesCavitation is the main mechanism for both laser and ultrasound thromboly ...

Abstract Accurately diagnosing epilepsy is very challenging and time consuming because clinicians rarely observe the actual seizure, and there are many different types of seizures and epilepsy syndromes with differing presentations. Furthermore, other neurological disorders can be mimics of seizures leading to erroneous diagnosis, inappropriate treatments with significant potential adverse events, ...

The high spatial resolution and energy resolution of cadmium zinc tellurideCZTand cadmium tellurideCdTecompared to that of scintillatorsoffers superior image quality in Nuclear medicine and X rayimaging applicationsi eSPECTPETCTBone DensitometryOncologyDental imagingAirportsecurityetcEven after two decades of researchCZT and CdTe remain the desired choice for roomtemperature radiation detectionbut ...