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The Award database is continually updated throughout the year. As a result, data for the given year is not complete until April of the following year. Annual Reports data is a snapshot of agency reported information for that year and hence might look different from the live data in the Awards Information charts.

  1. A novel assay for RNA targeted drugs

    SBC: NUBAD, LLC            Topic: NIGMS

    DESCRIPTION (provided by applicant): NUBAD, LLC is a drug discovery company devoted to identifying therapeutic agents that target nucleic acids. This project is designed to synthesize and characterize a novel class of fluorescently-labeled aminoglycosidesthat exhibit a dramatic change in fluorescence upon RNA binding. Aminoglycosides are a potent class of antibiotics that block bacterial protein s ...

    STTR Phase I 2011 Department of Health and Human Services
  2. Stroke Treatment by Chemically-Induced Hypothermia

    SBC: HALIMED PHARMACEUTICALS, INC.            Topic: NINDS

    DESCRIPTION (provided by applicant): Stroke is the third leading cause of death in the United States. In spite of intensive investigations, clinical therapies for treating acute stroke patients remain limited and unsatisfactory. There are consistent animal and human data that mild to moderate hypothermia (reducing body temperature to 32-34oC) is generally safe and improves outcome after brain ...

    STTR Phase I 2011 Department of Health and Human Services
  3. Solvothermal growth of low-defect-density gallium nitride substrates

    SBC: ADVANCED PHOTONIC CRYSTALS, LLC            Topic: AF10BT28

    ABSTRACT: This Small Business Technology Transfer Phase I project will address the problem of obtaining low-defect-density gallium nitride single crystals for substrates to enable low-defect, high-performance epitaxial growth. Gallium nitride is a very promising material for numerous applications including surface acoustic wave devices, high-powered LEDs, UV diode lasers and high-powered RF devic ...

    STTR Phase I 2011 Department of DefenseAir Force
  4. Continuous monitoring of anti-fibrinolytic therapy in cardiovascular surgery

    SBC: Micro Vide, LLC            Topic: NHLBI

    DESCRIPTION (provided by applicant): A major cause of morbidity and mortality in cardiovascular surgery is excessive bleeding post- operatively, which is commonly managed by pharmacologically modifying clot degradation (fibrinolysis), through inhibition of plasmin activity (PLact). However, the only FDA approved and most commonly used inhibitor of PLact in cardiovascular surgery, while effective i ...

    STTR Phase II 2011 Department of Health and Human Services
  5. AlInN/GaN HFET over Free-Standing bulk GaN substrates

    SBC: Sensor Electronic Technology, Inc.            Topic: MDA09T001

    SET, Inc. proposes to develop lattice-matched AlInN/GaN HFET structure on free-standing GaN substrate. By employing native low-defect GaN substrates and by using lattice-matched heterostructures with the incorporation of indium, we expect dramatic enhancement of these HFET in power density, reliability and high frequency operation. Homoepitaxial growth on native substrate and the use of AlInN/GaN ...

    STTR Phase I 2010 Department of DefenseMissile Defense Agency
  6. Continuous monitoring of anti-fibrinolytic therapy in cardiovascular surgery

    SBC: Micro Vide, LLC            Topic: NHLBI

    DESCRIPTION (provided by applicant): A major cause of morbidity and mortality in cardiovascular surgery is excessive bleeding post- operatively, which is commonly managed by pharmacologically modifying clot degradation (fibrinolysis), through inhibition of plasmin activity (PLact). However, the only FDA approved and most commonly used inhibitor of PLact in cardiovascular surgery, while eff ...

    STTR Phase I 2010 Department of Health and Human Services
  7. Novel Inhibitors of Pim Protein Kinases

    SBC: VORTEX BIOTECHNOLOGY CORPORATION            Topic: N/A

    DESCRIPTION (provided by applicant): There is a growing body of evidence that implicates the protein kinase Pim-1 as a major driver of prostate cancer progression, and perhaps response to chemotherapy. Pim-1 is overexpressed in early prostate intraepithelial neoplasia and metastatic prostate cancer, and its levels predict response to therapy. Pim-1-overexpressing mouse prostate stem cells demonstr ...

    STTR Phase I 2009 Department of Health and Human Services
  8. STTR Phase I: Ammonothermal Growth of Doped Aluminum Gallium Nitride Single Crystals for Energy Efficient Solid State Lighting and Tunable LED?s

    SBC: ADVANCED PHOTONIC CRYSTALS, LLC            Topic: MM

    This award is funded under the American Recovery and Reinvestment Act of 2009 (Public Law 111-5). This Small Business Technology Transfer Phase I project will address the problem of a multifunctional wide band-gap aluminum gallium nitride single crystal substrate that will enable low-defect, high-performance epitaxial growth. Since much of the energy consumed in the U.S. used for traditional ligh ...

    STTR Phase I 2009 National Science Foundation
  9. Acid Ceramidase, Target for Cancer

    SBC: Sphingogene, Inc            Topic: N/A

    DESCRIPTION (provided by applicant): Acid ceramidase (AC) has been implicated as a novel target for cancer therapy because of its pivotal role in regulating interconversion of three key bioactive lipids; ceramide (Cer), sphingosine (Sph) and Sphingosine-1-Phosphate (S1P). It is well known that Cer functions predominantly as a tumor suppressor lipid and mediator of apoptosis following chemo and rad ...

    STTR Phase I 2009 Department of Health and Human Services
  10. Developing a Mobile Torrefaction Machine

    SBC: AGRI-TECH PRODUCERS, LLC            Topic: 18d

    There are often major economic and logistical challenges in getting woody biomass out of the forest or off the farm in a manner, which justifies the costs of harvesting and transportation. Raw cellulosic biomass, woody or otherwise, is moist and bulky, which limits its cost-effective transport to ultimate users and leaves a lot of available biomass useless. In addition, many forests go without mec ...

    STTR Phase I 2009 Department of Energy

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