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The Award database is continually updated throughout the year. As a result, data for FY19 is not expected to be complete until April, 2020.

  1. Quality-Related eMeasures from EHR Data

    SBC: Commonwealth Informatics, Inc.            Topic: N/A

    To assess the readiness of EHR systems to support this new capability by constructing prototype eMeasure software, interfaced to at least one EHR system, that implements the chlamydia screening rate eMeasure based on HEDIS specifications for the numerator and denominator. Success in Plase I will support a Phase II activity to extend the prototype to additional EHR systems and additional existing a ...

    SBIR Phase I 2014 Department of Health and Human Services
  2. Lab research for the development of human anti-diphtheria Mabs in CHO cells

    SBC: Anatagen Pharmaceuticals, Inc.            Topic: N/A

    Monoclonal anitbodies (Mab) have been used successfully for treating human diseases. However, conventional Mabs are derived from mouse. Injection of murine Mabs into humans will cause adverse effects. The development of human Mabs against diphtheria could offer a commercially viable alternative to equine antitoxin for treating human diphtheria with a number of potential advantages including hig ...

    SBIR Phase I 2014 Department of Health and Human Services
  3. Development of Gap Junction Inhibition Therapy for Alcoholic Liver Disease

    SBC: HEPROTECH, INC.            Topic: NIAAA

    ? DESCRIPTION (provided by applicant): Alcoholic liver disease is a highly prevalent and costly condition affecting millions of people globally. Alcohol results in high morbidity and mortality an is responsible for nearly 4% of all deaths worldwide. Despite the tremendous societal and economic burden, there is no approved therapeutics for alcoholic liver disease. Instead, the standard of care ...

    SBIR Phase I 2014 Department of Health and Human Services
  4. Clinically suitable approach for gene-mediated therapy of cirrhosis.

    SBC: ADVANTAGENE, INC            Topic: NIAAA

    Abstract Persistent injury to the liver can cause chronic inflammation and dysregulated deposition of extracellular matrix (ECM), leading to accumulation of fibrotic scar tissue and eventually cirrhosis. While fibrosis is a normal wound healing response, in excess, it can further injure tissue and activate pro-fibrotic cells, resulting in a positive feedback loop. Scar tissue is not static, ECM re ...

    SBIR Phase I 2014 Department of Health and Human Services
  5. Novel Algorithm for Free Testosterone Determination


    DESCRIPTION (provided by applicant): The measurement of testosterone levels is central to the diagnosis of androgen disorders in men and women. Circulating testosterone is bound largely to sex hormone binding globulin (SHBG) and albumin; only the unbound or free fraction is biologically active. Therefore, in conditions that affect SHBG concentrations, such as aging, obesity, and diabetes, the dete ...

    SBIR Phase I 2014 Department of Health and Human Services
  6. Novel Compounds for Reducing Brain A-Beta Levels via Enhanced Systemic Clearance

    SBC: Akston Biosciences Corporation            Topic: NIA

    DESCRIPTION (provided by applicant): Alzheimer's disease (AD) is characterized by progressively worsening dementia eventually leading to death. It affects over five million people in the United States and costs the healthcare system over 200 billion per year. Currently there is no available therapy for slowing, reversing or preventing the disease. There is strong evidence suggesting that AD ...

    SBIR Phase I 2014 Department of Health and Human Services
  7. Antifungal Compound Discovery from Metagenomes


    DESCRIPTION (provided by applicant): There is societal need for new compounds in our arsenal of defenses against fungal pathogens, many of which are increasingly resistant to existing therapeutics. The best possible source for new antifungal compounds withpotentially novel mechanisms of action is within natural environments, particularly soils, which have the greatest diversity of microbial life. ...

    SBIR Phase I 2014 Department of Health and Human Services
  8. Targeted Inactivation of the CCR5 HIV Coreceptor with Peptide Nucleic Acids

    SBC: L2 DIAGNOSTICS, LLC            Topic: NIAID

    DESCRIPTION (provided by applicant): Over 34 million people are currently living with HIV/AIDS. Combination antiviral therapies have significantly reduced the morbidity and mortality of the disease; however, there is currently no cure for the disease. Discovery that a naturally occurring variant of CCR5, the delta32 mutation, renders cells resistant to HIV infection has led to efforts by several a ...

    SBIR Phase I 2014 Department of Health and Human Services
  9. Local Lymph Node Assay with IL-18 Endpoints


    DESCRIPTION (provided by applicant): The current industry standard for predicting contact dermal sensitization is the murine Local Lymph Node Assay (LLNA). A significant limitation of the LLNA is the frequency of false positives, as well as the occurrenceof false negatives. This limitation occurs as a result of the LLNA inability to always correctly distinguish between substances that are strongly ...

    SBIR Phase I 2014 Department of Health and Human Services
  10. Formulation of LbL microparticle vaccine in microneedle array for intradermal del


    Abstract The ability of the immune system to recognize and initiate an immune response to foreign particles such as bacteria and viruses has generated interest in development of particulate vaccine technologies. We are developing an innovative approach toproduce particulate vaccines via layer-by-layer (LbL) fabrication of synthetic microparticles (MP). We have shown that LbL-MP loaded with epitope ...

    SBIR Phase I 2014 Department of Health and Human Services

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