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The Award database is continually updated throughout the year. As a result, data for FY19 is not expected to be complete until April, 2020.

  1. Development of an Angiogenic T Cell Assay for Personalized Cytomics in Cardiovasc

    SBC: CYTOVAS, LLC            Topic: NHLBI

    DESCRIPTION (provided by applicant): The goal of this research is to develop a new flow cytometry-based test for the clinical measurement of proangiogenic T cells. Such an assay does not exist today. Proangiogenic T cells, including angiogenic T cell (Tang) and Th17 subsets, participate in reparative mechanisms in the vasculature, in oncogenic angiogenesis and in other processes central to the ove ...

    SBIR Phase I 2014 Department of Health and Human Services
  2. Improving Clinical Encounter Communications to Enhance Minority Diabetes Care

    SBC: Starship Health Technologies, LLC            Topic: NIMHD

    Disparities in healthcare delivery and outcomes have been linked, in part, to the difficulties physicians have in establishing effective communication with patients who differ from themselves in terms of race, ethnicity and economic circumstances. Diabetesmellitus and pre-diabetic nutrition-based obesity are an important case in point. Racial and socio-economic differences can impede doctors' ...

    SBIR Phase I 2014 Department of Health and Human Services
  3. Inter-alpha-inhibitors in Hypoxic-Ischemic Brain Injury

    SBC: PROTHERA BIOLOGICS, LLC            Topic: NINDS

    DESCRIPTION (provided by applicant): Neonatal hypoxia-ischemia (HI) remains a major cause of acute perinatal brain injury, leading ultimately to neurologic dysfunction manifesting as cerebral palsy, mental retardation, and epilepsy. Cerebral oxygen deprivation and/or reduced blood flow due to umbilical cord occlusion, prolonged labor, and/or intracranial hemorrhage produce an inflammatory respons ...

    SBIR Phase I 2014 Department of Health and Human Services
  4. Novel treatment for Huntington???s Disease

    SBC: Progenra, Inc            Topic: NINDS

    DESCRIPTION (provided by applicant): Because of their degeneracy and selective involvement in most cellular pathways, ubiquitin conjugating and deconjugating enzymes are being explored as therapeutic targets for treating many major diseases, including neurodegenerative disease. The proteasome-associated deubiquitylase (DUB) USP14 plays a key role in regulating proteasomal degradation of pathogenic ...

    SBIR Phase I 2014 Department of Health and Human Services
  5. Epigenetics Probes: Production of histone modifying enzymes and identification o

    SBC: REACTION BIOLOGY CORPORATION            Topic: NCATS

    DESCRIPTION (provided by applicant): Production of histone modifying enzymes and identification of chemical probes for epigenetic discovery Genomic function is the major factor in the most common diseases. Genomic function is regulated by the posttranslational methylation and acetylation state of histones. Histones are proteins found in cell nuclei that create nucleosomes into which DNA is structu ...

    SBIR Phase I 2014 Department of Health and Human Services
  6. Preclinical Development of Tacrolimus for Radiation Cystitis

    SBC: LIPELLA PHARMACEUTICALS, INC.            Topic: NIDDK

    DESCRIPTION (provided by applicant): This project, entitied Preclinical Development of Tracrolimus for Radiation Cystitis will fund key experiments to advance the commercial development of LP-10. LP-10 is a liposomal tacrolimus formulation for local (topical) intravesical administration to the urinary bladder. The formulation provides active drug levels in the bladder with significantly reduced ...

    SBIR Phase I 2014 Department of Health and Human Services
  7. Development and Deployment of the Movable Type Method for Drug Discovery and Desi

    SBC: QuantumBio, Inc.            Topic: NIGMS

    DESCRIPTION (provided by applicant): Our long-term goal is to provide a solution to the protein-ligand binding affinity and pose prediction problems. The protein-ligand docking and scoring problem is one of the central problems in computational biology because of its importance in understanding intermolecular interactions, and because of its practical payoff. The transformative impact molecular do ...

    SBIR Phase I 2014 Department of Health and Human Services
  8. Reducing heart failure re-admissions by enhancing sleep apnea treatment adherence

    SBC: AIRCARE LABS, LLC            Topic: NHLBI

    DESCRIPTION (provided by applicant): Hospital re-admission can be devastating for patients and carries significant financial burdens for health care systems. In 2013, the recently implemented Medicare Hospital Readmissions Reduction Program imposed 227 million in penalties on 2,225 hospitals. Medicare has focused on heart failure diagnoses because it is one of the most common causes of admission ...

    SBIR Phase I 2014 Department of Health and Human Services
  9. Targeted siRNA NanoJackets for the Personalized Treatment of Breast Cancer

    SBC: KEYSTONE NANO, INC.            Topic: NCI

    DESCRIPTION (provided by applicant): Most current chemotherapeutics have non-specific mechanisms of action and poor biodistribution profiles which result in dose-limiting toxicities tha prevent optimal efficacy from being obtained. Ribonucleic acid interference (RNAi) has the potential to be a safe, selective and personalized treatment approached for a variety of genetic-based diseases, including ...

    SBIR Phase I 2014 Department of Health and Human Services
  10. Rapid, Accurate, and Low-Cost Stool Clostridium difficile Genetic Test

    SBC: LENIMA FIELD DIAGNOSTICS, LLC            Topic: NIAID

    DESCRIPTION (provided by applicant): Clostridium difficile (CD) is a bacterium causing diarrhea and other intestinal problems linked to 14,000 annual deaths in the US. CDI is an antibiotic-associated infection as well as a health-care-associated infection.Current CDI diagnosis relies on CD toxins enzyme immunoassay (EIA) together with antigen (GDH) EIA. Although stool toxin EIA is specific and rel ...

    STTR Phase I 2014 Department of Health and Human Services

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