Award Data

PROJECT SUMMARY The cell surface CD protein is a marker of self and signals through its receptor signal regulatory protein SIRP expressed by macrophages to transmit an anti phagocytic donandapos t eat me signal CD is expressed by virtually all cell types is overexpressed by cancer cells as a mechanism to avoid immune surveillance and phagocytosis and is a negative prognostic f ...

Chronic musculoskeletal pain creates a significant public health burden, and Veterans are disproportionately affected. The frequency and extent of co-occurrence of pain and PTSD, pain and Traumatic Brain Injury (TBI), all three conditions (Post-deployment Multi-symptom Disorder (PMD), and other multi-symptom syndromes can complicate and reduce the effectiveness of pain treatment. Furthermore, the ...

PROJECT DESCRIPTIONJSK TherapeuticsJSKTDirect to Phase II Application Nitric oxideNOis a potentially powerful therapy against cancerSpontaneous NO generating drugs cannot be used to treat malignancies because of the pleiotropic effects of NOIn particularNO is a potent vasodilator with resultant hypotensionIn order to make NO based cancer therapy possibleit is necessary to develop agents that deliv ...

ABSTRACT The EEG PatchTM is a single channelelectrodewearablepatch like device designed for long termEEG recording in people with epilepsy to be used in their everyday environmentTo maximize the treatment of epilepsyit is critical to capture important day to day changes in EEG activity for long periods including the occurrence and duration of epileptiform events such The EEG Patch is unobtrusive a ...

ABSTRACT SignificanceGravesdiseaseGDone of the most prevalent autoimmune diseasesis caused by stimulating autoantibodiesTSAbto the Thyroid Stimulating Hormone ReceptorTSHRresulting in hyperthyroidismCurrent methods for managing hyperthyroidism in GD target excess thyroid hormone secretion by ablation or removal of the thyroid or by blocking thyroid hormone synthesisEach of these therapies is assoc ...

Project Summary Keratoconus KCN is a progressive disorder associated with structural changes in corneal collagen organization that leads to corneal thinning and ruptures in Bowman s layer and or Descemet s membrane As the disease progresses it leads to irregular astigmatism progressive myopia and subsequently poor visual acuity Treatment options are surprisingly limited with no oral or topi ...

Project Summary Identifying disease causing genetic variants is a complex process often involving the analysis of the genomes of affected patients and their immediate families When employing these state of the art techniques however the number of patients receiving a successful diagnosis is still only at approximately One reason for this low diagnosis rate is the presence of localised dat ...

Abstract Carbapenem resistant Enterobacteriaceae CRE pose a serious threat to public health These organisms cause infections that are associated with high mortality rates have the potential to spread widely and are resistant to all lactam agents and most other antimicrobials leaving virtually no treatment options Much CRE increase has been due to the spread of CRE that produce the carbapen ...

The gasoline engine is the prevalent engine in use today for automobiles and light trucks. In spite of the growth of various hybrids, clean diesel, and electric vehicles, it is projected to be in 71% of the vehicles produced globally in 2022. The gasoline engine has very poor efficiency at partial load typical of its usage in automobiles. Automobile engines can typically produce 200 or even 300 ho ...

This SBIR Phase I project will determine the feasibility of a new high risk technology for treatment of age-related macular degeneration (AMD). The technology is an AAV2-mediated concurrent expression of recombinant proteins to intracellularly suppress the critical growth factors VEGF-A (vascular endothelial growth factor A) and PDGF-B (platelet-derived growth factor) in a single injection. AMD is ...