Award Data

The broader impact/commercial potential of this project is to a wide range of electronics in the areas of communications, Internet, portable electronics, and power electronics. Although magnetic based transformers have been the industry standard for over a century they have many negatives including miniaturization difficulties, electromagnetic interference issues, and issues with larger voltage st ...

PROJECT SUMMARY Alcohol addiction and disorders associated to excessive alcohol use are a serious public health problem in the United States and in other parts of the world Current pharmacotherapies for the treatment of these disorders show limited efficacy Preclinical and clinical findings point to nicotinic acetylcholine receptors nAChRs as an alternative promising target for the developmen ...

Project Summary Abstract Multiple Myeloma MM is the second most common form of blood cancer and remains an incurable and deadly disease Proteasome inhibitor PI therapy is a cornerstone in the treatment of MM but resistance to this class of agent is an emerging challenge in the clinic New therapeutic approaches that specifically target resistance are needed to maximize responses and ultimate ...

PARP inhibitors PARPi are particularly efficacious in tumors deficient in the BRCA tumor suppressor genes but of limited activity in BRCA competent tumors There is an unmet medical need to develop targeted therapeutic agents which will augment PARPi activity for BRCA wild type cancers and to increase chemo radiosensitivity in these malignancies BRCA proteins are essential components ...

Project Summary Abstract An estimated million adults in the United States currently provide informal care to relatives and friends with Alzheimer s disease The economic contribution of informal caregivers service is estimated in the billions and is the cornerstone of care for the million people with the disease While informal caregivers undoubtedly perform an important role the respon ...

PROJECT SUMMARY Alzheimer s disease AD affects million people worldwide costing $ billion yearly One in nine Americans over the age of have AD the th leading cause of death in the US Annually $ billion is spent to care for the million Americans with AD AD is the only cause of death in the top that cannot be prevented cured or slowed and without the development of tre ...

Project summary Therapeutic strategies that seek to stimulate adaptive immunity for the treatment of cancer have recently shown convincing clinical efficacy Immune checkpoint inhibitors CPIs for example reactivate a patient s own T cells to eliminate tumors by blocking interactions that cause tumor infiltrating lymphocytes TILs to become exhausted CPIs have demonstrated remarkable success ...

ABSTRACT The EEG PatchTM is a single channel electrode wearable patch like device designed for long term EEG recording in people with epilepsy to be used in their everyday environment To maximize the treatment of epilepsy it is critical to capture important day to day changes in EEG activity for long periods including the occurrence and duration of epileptiform events such as spike wave d ...

Establishing the functional viability and dose response of Duck Duck Punch A Stroke Rehabilitation Computer Game ABSTRACT Only of stroke survivors experience full recovery of arm hand movement Long term arm movement impairment restricts independence with self care and vocational activities increases caregiver burden and reduces quality of life Strong evidence is emerging that traditional ...

This Small Business Innovation Research (SBIR) Phase II project is for the development of scaled processes for the industrial manufacture of end-user moldable advanced composite materials for use in protective athletic equipment. Currently, protective athletic equipment and accessories must be produced using industrial manufacturing techniques that have high tooling costs. As a result, manufacture ...