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The Award database is continually updated throughout the year. As a result, data for FY19 is not expected to be complete until April, 2020.

  1. Development of a New Carbohydrate based Anticoagulant Drug

    SBC: Glycan Therapeutics LLC            Topic: NHLBI

    Low molecular weight heparins LMWHs a commonly used anticoagulant drug in the hospitals are carbohydrate based molecules Heparin is isolated from porcine intestine through a long and unreliable supply chain LMWH is a depolymerized product of heparin A worldwide distribution of contaminated heparin in impacting the purity and safety of LMWHs was associated with deaths in the US Th ...

    STTR Phase I 2017 Department of Health and Human ServicesNational Institutes of Health
  2. Point of Care Imaging for Cardiovascular Monitoring Light Energy Tissue Interactions

    SBC: RFPi, Inc.            Topic: NHLBI

    A research team of clinical medicine optical physics mechanical and electrical engineering disciplines at ECU has invented a new biomedical imaging technology Multi Spectral Physiologic Visualization MSPV MSPV is a proprietary laser illuminated hardware software imaging system that is non contact cm imaging distance non invasive no dyes or injections non ionizing no X ray CT an ...

    STTR Phase I 2017 Department of Health and Human ServicesNational Institutes of Health
  3. A Novel Hernia Mesh to Improve Anchor Point Fixation and Prevent Hernia Formation

    SBC: Deep Blue Medical Advances, Inc.            Topic: 300

    Abstract Two million laparotomies are performed annually in the U S with ventral hernia being a frequent complication in of patients The average cost patient for each hernia operation in the U S in was $ which amounts to $ billion annually The ten year ventral hernia recurrence rate is There are $ B in hernia meshes sold annually in the United States With ...

    STTR Phase I 2017 Department of Health and Human ServicesNational Institutes of Health
  4. Development of a POEGMA Aptamer rapid onset anticoagulant that eliminates antigenicity to anti PEG antibodies

    SBC: Gateway Bio, Inc.            Topic: NHLBI

    ABSTRACT The objective of this STTR proposal is to reformulate a promising PEG aptamer rapid onset anticoagulant ROA by applying a novel PEG like POEGMA polymer brush technology capable of eliminating anti PEG antigenicity The importance of this proposal is highlighted by the early termination of a recent Phase III clinical trial of the original PEG aptamer conjugate in which severe allergic ...

    STTR Phase I 2017 Department of Health and Human ServicesNational Institutes of Health
  5. HLS Cyclic CAR peptide a targeted therapy for pulmonary hypertension

    SBC: VASCULAR BIOSCIENCES            Topic: NHLBI

    PUBLIC ABSTRACT This project in response to announcement HLS describes a development program for CARSKNKDC CAR a synthetic cyclic peptide that selectively targets diseased pulmonary vascular endothelium and enhances the therapeutic effect of vasodilator therapies for the treatment of pulmonary hypertension PH PH is a disorder of elevated pulmonary vascular resistance characterized by ...

    STTR Phase I 2017 Department of Health and Human ServicesNational Institutes of Health
  6. Tuned stem cell extracellular vesicles as a novel chronic wound therapeutic

    SBC: ZEN-BIO, INC.            Topic: NIA

    Project Summary The elderly population is rapidly increasing worldwide and those over years old are expected to comprise of the total population by These demographic changes will focus healthcare needs on those conditions more prevalent in the elderly Chronic wounds such as venous leg ulcers pressure ulcers and diabetic ulcers are over represented in the elderly population and even ...

    SBIR Phase I 2017 Department of Health and Human ServicesNational Institutes of Health
  7. BurntOut Role Play Simulation for Building Medical Student Resiliency

    SBC: Clinical Tools, Inc            Topic: 400

    We propose to produce a simulation experience to ensure that clinical year medical students are prepared for have coping strategies to deal with and are more resilient to the stresses and challenges that await them as they transition to clinical practice and learning in a clinical environment The experience will guide institutional level change by anonymously communicating studentsandapos conc ...

    SBIR Phase I 2017 Department of Health and Human ServicesNational Institutes of Health
  8. A neurokinin receptor agonist to treat underactive bladder in the elderly

    SBC: Dignify Therapeutics LLC            Topic: NIA

    PROJECT SUMMARY ABSTRACT Underactive bladder UAB is a condition wherein a bladder contraction of reduced strength and or duration results in prolonged bladder emptying and or a failure to achieve complete bladder emptying within a normal time span The overarching hypothesis of this application is that in the absence of physiologically induced bladder contractions pharmacologically induced co ...

    SBIR Phase I 2017 Department of Health and Human ServicesNational Institutes of Health
  9. A D osteoarthritis model targeting patient populations with high risk genetic polymorphisms

    SBC: Cytex Therapeutics, Inc.            Topic: NIAMS

    Abstract Osteoarthritis OA is a degenerative joint disease that affects an estimated million adults in the United States and results in an economic burden of over $ billion per year Although the burden of OA is immense current non surgical treatments are only palliative and no disease modifying OA drugs DMOADs presently exist to address the problem This lack of success in identifying ...

    SBIR Phase I 2017 Department of Health and Human ServicesNational Institutes of Health
  10. Novel PhageLock assay to measure hepcidin for clinical monitoring

    SBC: AFFINERGY, LLC            Topic: 400

    SUMMARY ABSTRACT Hepcidin is the peptide hormone responsible for regulating circulating iron concentrations Overexpression of hepcidin results in severe iron deficiency and anemia whereas hepcidin deficiency leads to iron overload Not surprisingly abnormalities in hepcidin production and circulating concentrations are highly correlated with various disease states such as renal disease cancer ...

    SBIR Phase I 2017 Department of Health and Human ServicesNational Institutes of Health

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