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The Award database is continually updated throughout the year. As a result, data for FY19 is not expected to be complete until April, 2020.

  1. Generating a Porcine Model for Human Microvillus Inclusion Disease (MVID) by Gene Editing

    SBC: Recombinetics, Inc.            Topic: 300

    DESCRIPTION provided by applicant Microvillus inclusion disease MVID is the most severe cause of Congenital Diarrheal Diseases in neonates MVID results from mutations that lead to malabsorption and life threatening intractable secretory diarrhea To date no curative therapy exists MVID patients are largely dependent on parenteral nutrition Prognosis is generally poor due to metabolic d ...

    SBIR Phase I 2016 Department of Health and Human Services
  2. Rapid manufacturing of recombinant nucleosomes for high-throughput assays

    SBC: EPICYPHER, INC.            Topic: 100

    DESCRIPTION provided by applicant Chromosomes are composed of genomic DNA and associated protein components that exert powerful regulatory effects The nm nucleosome represents the functional unit of chromatin comprising turns of genomic DNA bp wrapping an octamer of histone proteins Post translational modification PTM of the histones e g methylation acetylation or ubiquiti ...

    SBIR Phase I 2016 Department of Health and Human Services
  3. Low Cost Microphysiological System for Improved Pharmacodynamics

    SBC: SCIKON INNOVATION, INC.            Topic: 300

    DESCRIPTION provided by applicant The high failure rate of drugs in late stage development nearly is a symptom of the inadequacy of pre clinical animal models to accurately predict human biology One of the major reasons drugs fail in the clinic is inaccurate prediction of the therapeutic index which is the dose range where drugs are effective and also not toxic Failure to identify meta ...

    SBIR Phase I 2016 Department of Health and Human Services
  4. Novel tools for site-specific ablation of the mitochondrial genome

    SBC: Enzerna Biosciences LLC            Topic: 200

    DESCRIPTION provided by applicant Millions of individuals are affected by diseases caused by mutations in mitochondrial encoded genes which lead to a diverse set of clinical disorders ranging from visual impairment optic neuropathy to accelerated aging to hypertrophic cardiomyopathy Unfortunately there are no commercially available technologies that can enable investigators to dissect the f ...

    SBIR Phase I 2016 Department of Health and Human Services
  5. Semi-autonomous Robotic Powered Wheelchair Functionality

    SBC: Innovative Design Labs Inc.            Topic: NICHD

    DESCRIPTION provided by applicant Mobility limitations are the leading cause of functional limitations among adults and are strong predictors of activities of daily living ADL Impaired mobility often results in decreased opportunities to socialize and can lead to social isolation anxiety and depression There are many impairments for which driving a powered wheelchair can be a challenge in ...

    SBIR Phase I 2016 Department of Health and Human Services
  6. Shape RNA Structure Analysis for Drug Discovery and Translational Research

    SBC: Ribometrix LLC            Topic: 200

    DESCRIPTION provided by applicant Roughly of the human genome is transcribed into RNA and in most of these RNAs complex higher order structures underlie or fundamentally affect critical biological processes RNA structures are the targets of many antibiotics and RNA structure should be further exploited in small molecule drug discovery efforts For example structures in the genomes of R ...

    SBIR Phase I 2016 Department of Health and Human Services
  7. High-throughput methyltransferase assays using recombinant nucleosome substrates

    SBC: EPICYPHER, INC.            Topic: 200

    DESCRIPTION provided by applicant Methylation of chromatin recruits various regulatory proteins to govern gene expression and represents the most common epigenetic regulator To understand this common mechanism for the modulation of gene expression it is important to study the interaction between human methylation enzymes and their chromatin targets histone proteins Currently the study of ...

    SBIR Phase I 2016 Department of Health and Human Services
  8. Rapid POC Toxin Assay using Aptamer-Functionalized Magnetic Nanoparticles

    SBC: KORONIS BIOMEDICAL TECHNOLOGIES CORP.            Topic: NHLBI

    DESCRIPTION provided by applicant There is a need for the ability to perform rapid and specific bio monitoring of a wide range of toxins for use by clinicians environmental epidemiologists and emergency medical responders Ultra miniature GMR magnetic sensors based on very mature technology developed by the magnetic recording industry are well suited to form the basis of an innovative toxin ...

    SBIR Phase I 2016 Department of Health and Human Services
  9. Development of a GABA Enzyme for Biosensor and Point-of-Care Applications

    SBC: Pinnacle Technology, Inc.            Topic: 101

    DESCRIPTION provided by applicant As the most important inhibitory neurotransmitter in the brain a detailed understanding of the implications of gamma aminobutyric acid GABA release remains elusive The measurement of GABA concentrations is a difficult process Microdialysis is the current standard for GABA sampling in the brains of freely moving animals but suffers from low temporal resolu ...

    SBIR Phase I 2016 Department of Health and Human Services
  10. Novel Low Cost QTc Meter for Long QT Syndrome Screening in Primary Care

    SBC: Minnesota HealthSolutions Corporation            Topic: NHLBI

    DESCRIPTION provided by applicant Minnesota HealthSolutions MHS iCardiac Technologies and the Mayo Clinic propose the development and evaluation of an inexpensive diagnostic device the QTc Meter to support simplified widespread screening in the primary care environment for both congenital long QT syndrome LQTS and acquired drug induced LQTS This grant focuses specifically on the QTc Me ...

    SBIR Phase I 2016 Department of Health and Human Services

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