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SUMMARY Natural products derived from plants have played crucial roles in the treatments of many diseases throughout historyHoweverscarce natural sources and complex chemical synthesis have limited research and development and increased costs on these productsAn example of this is the non psychoactive cannabinoids found in cannabis plantsThere are overlow abundant cannabinoids that are known to be ...

PROJECT SUMMARY Genomic instabilityinduced by DNA damageand partly mitigated by DNA repair and antioxidantsplays a critical role in the pathogenesis of many major human diseasessuch as neurodegenerationcancer and cardiovascular diseasetogether with agingThere is a critical need for automated assays that can perform these assessmentsand bring them into greater routine usewhich will help advance our ...

Leadless cardiac pacemakersLCPsrepresent a revolutionary leap forward in cardiac pacing technology via its circumvention of transvenous leadsCurrent LCP lithium CFX batteries arecc resulting in an overallcc LCP deviceThis Phase I effort will demonstrate the feasibility of acc betavoltaic battery for LCPs with ayear lifetimex lifetime of current LCP batteriesenabling LCPs with a volumetric size ofc ...

Preclinical positron emission tomographyPETplays a significant role in monitoring radiotracer biodistributions for the development of new therapiesThe standardized uptake valueSUVhas become one of the most important quantitation measures in PET analysisHoweverSUV extraction from PET data hinges on the ability to clearly delineate the organ region of interestROIfrom an anatomical referenceCross com ...

PROJECT SUMMARY Hantaviruses are an emerging family of highly pathogenic viruses that cause 100-200,000 cases of two severe febrile illnesses a year; Hantavirus cardiopulmonary syndrome (HCPS) and hemorrhagic fever with renal syndrome (HFRS). While the annual incidence of infections are relatively low compared to other viral infections, some hantavirus strains are particularly deadly, causing a 35 ...

The rapid development of next generation sequencingNGStechnologies has allowed researchers to make unprecedented progress in the analysis of genomesthe results of which have profound implications for human healthThe ability to fully characterize genomes remains unrealizedhoweverdue in large part to our inability to reconcile sequence information over long distancesCurrent long readlong templateand ...

Outbreaks have become a significant public threat in hospitalsimpacting both patient lives and creating a financial burdenWith the increasing rise in antibiotic resistancenew interventions are urgently needed to contain ongoing outbreaksRecent studies have confirmed that whole genome sequencingWGSis able to identity unique mutations within each outbreak strainwhich can then be utilized to establis ...

Project SummaryAn extensible analysis platform will be developed to accurately perform the automated genotyping of PCR capillary electrophoresisCEtraces for multiple disease associated short tandem repeaterSTRassaysThis study will evaluate the feasibility of developing generalizable and adaptive molecular analysis modelsand will ultimately establish a new paradigm for deep learning analytical tool ...

PROJECT SUMMARYArsenic in drinking water poses a serious health hazard to tens of millions of peopleespecially in parts of the world where the arsenic concentrations far exceed theppb guideline value set by the World Health OrganizationAccording to a recent studyapproximatelyM people in the conterminous U Suse water from domestic wellsmillion out of themillion peopleare predicted to be using wells ...

ABSTRACTUpper airway surgery encompasses a group of procedures commonly used to treat upper airway obstructionincluding maxillomandibular advancementsurgery of the soft palatenasal surgerytongue reduction surgeryand correction of tracheal stenosisCurrent diagnosis and the subsequent decision making of these pathologies primarily rely on the clinical examination and objective measures such as acous ...