Award Data

PROJECT SUMMARY Cognitive decline and deterioration of long term cognitive performance are major side effects of CNS cancer treatmentBrain metastases are the most common CNS malignancies and a common cause of morbidity and mortality in aboutof all cancer patients with systemic diseaseaffecting overpatients in the US annuallyAs most systemic chemotherapy agents do not cross the blood brain barriert ...

Project Summary The overall research goal of this Phase I effort comprises developing and evaluating the feasibility and effectiveness of a prototype of a new software product called ASKAssessing STEM KnowledgeASK is being developed as a teaching tool for use on mobile tablet devices by teachers and students of high school algebra in rapidly emerging one to onee learning environmentsIn e learningr ...

Summary/Abstract The overall objective of this project is to develop new, potent, selective antimalarials that act through a novel mechanism of blocking the plasmodial surface anion channel (PSAC), a previously unexploited and highly conserved plasmodial target. Human malaria is caused by five species of protozoan parasites in the genus Plasmodium. It is estimated that there are more than 200 mill ...

PROJECT SUMMARY Cholera is an acute and severe disease caused by the bacterium Vibrio cholerae that is spread primarily through contaminated water sources due to a lack of adequate sanitation infrastructure. The World Health Organization estimates that there are at least 3 million cases globally per year, 40 percent of which are spread through household transmission. Current prevention methods req ...

The rapid development of next generation sequencingNGStechnologies has allowed researchers to make unprecedented progress in the analysis of genomesthe results of which have profound implications for human healthThe ability to fully characterize genomes remains unrealizedhoweverdue in large part to our inability to reconcile sequence information over long distancesCurrent long readlong templateand ...

Project SummaryAbstract Despite recent advances in allogeneic stem cell transplantationgraft versus host diseaseGVHDan immunologic attack by donor cells directed against the recipientand reactivation of latent viral infections remain major sources of post transplant morbidity and mortality and limit the applicability of bone marrow transplantThe morbidity of GVHD is particularly unwelcome in non m ...

Project Summary Abstract Hepatocellular carcinomaHCCis the most common primary liver cancer and arises from chronic liver diseasesCLDincluding hepatitis B virusHBVhepatitis C virusHCValcoholic liver diseaseALDand nonalcoholic steatohepatitisNASHTodaypatients with CLDs are at high risk for HCC and are monitored closely by imaging and serum biomarkersbut these platforms lack sensitivity for early st ...

Project SummaryAn extensible analysis platform will be developed to accurately perform the automated genotyping of PCR capillary electrophoresisCEtraces for multiple disease associated short tandem repeaterSTRassaysThis study will evaluate the feasibility of developing generalizable and adaptive molecular analysis modelsand will ultimately establish a new paradigm for deep learning analytical tool ...

PROJECT SUMMARYArsenic in drinking water poses a serious health hazard to tens of millions of peopleespecially in parts of the world where the arsenic concentrations far exceed theppb guideline value set by the World Health OrganizationAccording to a recent studyapproximatelyM people in the conterminous U Suse water from domestic wellsmillion out of themillion peopleare predicted to be using wells ...

Summary Cell free DNAcfDNAin peripheral blood contain tumor derived DNA and are promising noninvasive biomarkers for cancer therapy selection and recurrence monitoringHoweverthe high cost of current commercial next generation sequencingNGSpanels for profiling cancer mutations in cfDNA prevents them from being routinely usedFurthermorethe high sequencing depth and reads required means that cfDNA pr ...