Award Data

Multidimensional flow cytometry allows the discrimination of neoplastic cells from their normal counterparts. Using technology for the simultaneous measurement of 5 parameters, the abnormal expression of normal antigens can be used to identify leukemic populations. Distinction between normal and abnormal cells can be made by a highly trained scientist using a computer program which permits visuali ...

Our ultimate goal is to develop small, inexpensive, disposable devices for rapid, on-site identificbiologically active molecules (hormones, metabolites, specific bacteria, etc.). The goal is based onloading onto a biosensitive material. An increase in mass on the surface of the biosensitive materiasignal received by an automatic reader. The investigators will design a screening system with two bir ...

Emerging principles of prevention science support the application of risk-focused strategies for thalcohol, tobacco, and other drug (ATOD) abuse. Communities nationwide are currently developing preveprogramming based on the risk focused model. Successful programming depends upon ongoing collectionreliable epidemiological data on risk and protective factors (RPF) and drug use to guide decision maco ...

The long-term objective of this project is to commercially develop a target-specific chemopreventatinflammatory bowel diseases that works by releasing the therapeutic agents directly in the lower intsite of the disease. It is noted that ulcerative colitis and Crohn's disease are the most severe infno truly effective preventative measures are available. It is indicated that the substance to be sync ...

The overall objective of this program is to commercially develop a novel Intraoral Chlorhexidine (CSystem for physically handicapped patients which is superior to the currently marketed oral care prorely on patient compliance for effectiveness in preventing the development of plaque and gingivitis.this Phase I proposal are to demonstrate the technical feasibility of preparing 3-5,000 controlled r( ...

N/A

We will develop an intelligent decision support system for optimal insulin dosing for Type l Diabetmanagement. The hypothesis used in this study is that case-based reasoning (CBR) methodology in theintelligence (AI) can learn an individual's unique response to diet and exercise and provide a comprits decision in each case; and that the self-organizing fuzzy neural network controller (SOFNNC) canan ...

N/A

Electrical stimulators are widely used in biological and medical research, diagnostics and clinicalExamples include: bone healing, wound healing, and nerve regeneration; rehabilitation medicine; funcstimulation; control of pain; neurophysiological research and diagnostics. There is no single piececover the experimental needs in all of these areas. Biomedical researchers often find themselves devst ...

Bitistatin is a 84 amino acid peptide that recognizes the platelet glycoprotein IIb/IIIa receptor ademonstrated to target specifically to thrombi and emboli. The limited supply of bitistatin, as of tsnake venom of Bitis Arietans. The objective of this project is to produce bitistatin as a recombinabacteria or yeast, to ensure a sufficient and consistent supply of a homogenous protein, which is esc ...