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Project Summary This work will develop an innovative infusion device that leverages new electronics and sensor capabilities to produce a medical device that improves intravenous (IV) infusion delivery. IV infusions are among most common healthcare procedures administered worldwide; an estimated 80% of hospital patients receive some IV therapy. Infusions are also increasingly delivered outside of h ...

ABSTRACT Allogeneic hematopoietic cell transplantation (allo-HSCT) is an effective therapy for a number of malignant and non- malignant blood and metabolic diseases, but its applicability has been limited by graft-versus-host disease (GvHD). GvHD is responsible for 15-30% of deaths that occur following HSCT and is the main cause of morbidity in up to 50% of recipients. Current prevention and treat ...

SUMMARY The current rapid antigen detection tests for group A strep lack sensitivity and result in upwards of 10 million unnecessary antibiotic treatments provided to children each year. Current diagnostic methods utilized when a patient presents at a clinic with a sore throat include a throat swab and rapid strep test. A positive rapid test results in antibiotic prescription, but due to the low s ...

Project Summary Genetic predispositions in the human population are associated with unpredictable pharmacokinetic (PK) and pharmacodynamics (PD), which result in the loss of treatment efficacy or increase risks of adverse drug reactions (ADRs). The FDA estimates that ADRs are the 4th leading cause of death in the US, and treatment costs related to ADRs exceed $136 billion annually. Drug-induced li ...

PROJECT SUMMARY The Botulinum Toxin Potency Assay using Tissue Chips program from FDA and NCATS highlights the need for novel engineered systems capable of reliably evaluating botulinum toxin (BoT) potency. Human induced pluripotent stem cell (iPSC)-derived motor neurons and muscle cells have been previously maintained in co- culture and shown to form functional synaptic contacts representing in v ...

Project Summary/Abstract Glioblastoma (GBM) is one of the most common and deadliest form of malignant brain tumors, with median patient survival of 12-15 months and five-year survival of less than 5%. The current standard of therapy for GBM comprises surgical resection then radiation and chemotherapy. However, due to the heterogeneity and invasive nature of GBM tumor cells there is a high rate (~8 ...

Project Summary Flow cytometry is widely used in basic and translational research and in clinical diagnostic assays. Spectral flow cytometry represents a revolutionary change in the approach to flow cytometry by using full spectral information from each fluorophore—by collecting the emission over the full spectrum and using multiple excitation sources for each fluorophore to obtain a spectral †...

PROJECT SUMMARY Glycans play crucial roles in nearly every aspect of biological processes, and their distinct properties make them appealing as disease biomarker targets. However, due to their highly branched and variably linked nature, glycans pose a challenge for detection, purification, and structural analysis. Although advanced analytical techniques and instrumentation have been developed that ...

KDH Research and Communication (KDHRC) submits this Phase II Small Business Innovation Research (SBIR) application to expand and fully evaluate Guardians Receiving Information through Navigators (GRIN). GRIN is a culturally competent, online professional development course to prepare community health workers (CHWs) to provide oral health outreach to low- income Black parents/guardians (henceforth ...

Abstract Urinary catheters are one of the most widely used medical devices in a hospital setting and are expected to only increase in growth due to the aging population. Out of all the various biomedical devices that are frequently used in a clinical setting, urinary catheters are associated with the largest portion of medical complications related to infection. Catheter associated urinary tract i ...