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The Award database is continually updated throughout the year. As a result, data for FY19 is not expected to be complete until April, 2020.

  1. Not Available

    SBC: Gencia Corporation            Topic: NCI

    Bioenergetic dysfunction is a well- recognized feature of most (< 97%) metastasizing tumors. Dysfunction of major cell proliferation controllers mutated in the majority of neoplasms, such as the p53, Ras, Myc, PI3K/Akt pathways, results in suppression of mitochondrial oxidative phosphorylation (OXPHOS) and in activation of glycolysis, known as the Warburg effect, which contributes to the resistanc ...

    SBIR Phase I 2010 Department of Health and Human Services
  2. Microarray based STR genotyping utilizing RecA-mediated ligation

    SBC: GENE CHECK, INC.            Topic: NHGRI

    DESCRIPTION (provided by applicant): Tandem repeat sequences (STR) are distributed widely in the human genome. These sites exhibit high levels of length polymorphism as a result of their relative instability during DNA replication, i.e., the tendency for slippage to occur between the template and newly synthesized strands causing deletion or addition of repeat units. Changes in STR repeat numb ...

    SBIR Phase II 2010 Department of Health and Human Services
  3. Prostate Cancer In Vivo Using an Ultra Low Field MRI Device

    SBC: High Precision Devices, Inc.            Topic: NCI

    DESCRIPTION (provided by applicant): Prostate cancer (PCa) is the second leading cause of male cancer deaths in the U.S., and although the disease can be managed or treated in many ways, clinicians lack suitable scanning tools for diagnosing and tracking PCa. Conventional magnetic resonance imaging (MRI) at 1.5 tesla and above is used increasingly for the detection, diagnosis, and staging of cance ...

    SBIR Phase I 2010 Department of Health and Human Services
  4. CREATION OF STANDARDS AND DEVELOPMENT OF MOLECULAR CLINICAL DIAGNOSTIC FOR ENTERI

    SBC: PHRIXUS PHARMACEUTICALS, INC.            Topic: NIAID

    DESCRIPTION (provided by applicant): This one-year phase I SBIR proposal will apply the benefits of molecular testing, in terms of speed, sensitivity, and ultimately value, to diagnose enteric Microsporidia (Enterocytozoon bieneusi and Encephalitozoon intestinalis). Molecular diagnostics are the future for infectious disease diagnostics, with a projected 13% rate of revenue increase between 2009 a ...

    SBIR Phase I 2010 Department of Health and Human Services
  5. Not Available

    SBC: Indoor Biotechnologies Inc            Topic: NIEHS

    Molds cause asthma and allergic respiratory diseases and are associated with other illnesses such as sinusitis, chronic fatigue syndrome, lethargy, or migraines. Mold occurs in damp or water damaged housing. The relationships between mold exposure and health effects are poorly understood. The aim of this project is to develop a multiplex array for mold biomarkers that will measure 4-7 biomarker ...

    SBIR Phase I 2010 Department of Health and Human Services
  6. DNA Detection Switch (DDS) probes for diagnosis of multi-drug resistant tuberculo

    SBC: GENETAG TECHNOLOGY, INC.            Topic: NIAID

    DESCRIPTION (provided by applicant): DDS diagnostic probe systems for MDR-TB Principal Investigator, Shafer, David A. PhD Abstract: Tuberculosis (TB) is a primary cause of morbidity and mortality in many areas of the world with about 8 million new cases and 2 million deaths per year. In recent years, there has been a rapid and alarming increase in the incidence and spread of drug resistant TB and ...

    SBIR Phase I 2010 Department of Health and Human Services
  7. Next Generation Capsule Endoscopy Video Data Acquisition and Visualization Platfo

    SBC: Altrum Technologies, Inc            Topic: NCRR

    DESCRIPTION (provided by applicant): Gastrointestinal (GI) malignancies are the most common cause of cancer in the world. Of the 10.8 million people in the world each year who develop cancer, approximately 3.3 million have GI malignancies. Aside from prevention, effective, low cost, and comfortable early diagnosis technologies are urgently needed to improve this situation. Traditional endoscopic o ...

    SBIR Phase I 2010 Department of Health and Human Services
  8. Completely Digitizing the Custom-Fit Hearing Aid Shell Manufacturing Process

    SBC: Altrum Technologies, Inc            Topic: NIDCD

    DESCRIPTION (provided by applicant): The average hearing aid costs 1,500, but prices can go up to 5,000 each. Yet Consumer Reports indicates that 40 percent of hearing aid users are unhappy with their devices. Between 25 percent and 30 percent of custom-fit hearing aids are returned and/or need to be remade and another 20 percent end up sitting unused in a bureau drawer. Just as disturbing, of t ...

    SBIR Phase I 2010 Department of Health and Human Services
  9. Multichannel Electrosonic Actuation Microarray for Cell-Based Screening

    SBC: OPENCELL TECHNOLOGIES, INC.            Topic: NCRR

    DESCRIPTION (provided by applicant): High-throughput, parallel delivery and transfection of biologically relevant material into cells remains a difficult task. The proposed work addresses this issue through integration of multiple Electrosonic Actuation Microarrays (EAMs) into a single MIST (Multiple Integrated Sample Treatment) device that is optimized for parallel drug and/or gene/nucleic acid d ...

    SBIR Phase I 2010 Department of Health and Human Services
  10. Computer-based HIV Prevention for Seropositive Men

    SBC: ISA ASSOCIATES INC            Topic: NIMHD

    DESCRIPTION (provided by applicant): Since the late 1990s, the number of new HIV infections has held steady at approximately 50,000 new cases each year. At first glance, this 10-year stability in incidence rate appears to challenge the notion that HIV prevention efforts have been successful. However, antiretrovirals (ARVs) also became widely availability at the same time incidence rates stabilized ...

    SBIR Phase I 2010 Department of Health and Human Services

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