Award Data

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The Award database is continually updated throughout the year. As a result, data for FY19 is not expected to be complete until June, 2020.

  1. Pharmacologic Suppression of Reperfusion Injury Following Endovascular Thrombectomy In Stroke.

    SBC: BIOMIMETIX JV LLC            Topic: 102

    Ischemic stroke is a leading cause of death and disability in the United StatesThis often is attributable to thrombus formation at an atherosclerotic plaque or thromboembolismPatients who present withinhours of symptom onset are eligible for thrombolysis with tissue plasminogen activatortPAThis serves andltof victimsRecentlymajor advance has been made with proven efficacy from endovascular mechani ...

    STTR Phase I 2019 Department of Health and Human ServicesNational Institutes of Health
  2. Non-Invasive Physiologic Evaluation of Peripheral Arterial Disease

    SBC: RFPi, Inc.            Topic: NHLBI

    ABSTRACT Peripheral Arterial DiseasePADis a substantial healthcare burden in the USestimated andgtMand around the worldestimated andgtMIn the aging populationoverwith age andgtyears have PADof all patients with PAD are asymptomaticand up toof the remaining patients have atypical symptomsThe conventional ankle brachial indexcABIratio is established as the initial diagnostic evaluation in symptomati ...

    STTR Phase II 2019 Department of Health and Human ServicesNational Institutes of Health
  3. Oral Enzymatic Management of Phenylketonuria

    SBC: Abri Science, LLC            Topic: 300

    PhenylketonuriaPKUis a genetic disorder of metabolism characterized by a pathological elevation of phenylalaninePhein the body stemming from a dysfunctional phenylalanine hydroxylase enzymePAHThe resulting high concentrations of Phexcan result in severe intellectual disabilitybehavioral problemsand neurological deficitse gseizuresStrict control of dietary Phe is the primary treatment for PKU curre ...

    STTR Phase I 2019 Department of Health and Human ServicesNational Institutes of Health
  4. Infection Site Targeted Antitoxin Antibody (ISTAb) against Bacillus anthracis

    SBC: Integrated Biotherapeutics, Inc.            Topic: NIAID

    Project Summary Bacillus anthracisBais a Gram positive spore forming bacterium that is listed as an agent of highest concernCategory Aby NIAID and CDCBa is easy to growand its spores can be formulated into highly stable powder form and disseminated as aerosol or used to contaminate food or waterInletters laced with powdered anthrax spores were mailed to several US politiciansTwenty two peopleinclu ...

    STTR Phase II 2019 Department of Health and Human ServicesNational Institutes of Health
  5. Multi-Modal Mechanisms of Novel Sulfated Non Anticoagulant Heparin inSickle Cell Disease Management

    SBC: VASCULAR VISION PHARMACEUTICAL CO            Topic: NHLBI

    AbstractThe pathogenesis of Sickle cell diseaseSCDcomprises a complex interplay of factors associated with vascular endothelial activationintense inflammationand increased sickle cell adhesionMicrovascular occlusion in SCD is initiated by adhesion of sickle red blood cellsRBCsto the endotheliumleading to acute painful vasoocclusive crisisVOCand the clinical morbidity in SCDTreatment strategies inc ...

    STTR Phase I 2019 Department of Health and Human ServicesNational Institutes of Health
  6. Multielectrode Arrays for Neurotransmitter Detection with Fast Scan Cyclic Voltammetry

    SBC: Microprobes for Life Science, Inc.            Topic: 101

    Project Summary Abstract The brain is by far the most complex and heterogeneous organ in the human bodyFor yearsthere has been a growing and unmet need to develop multielectrode arrays for neurotransmitter sensing in multiple brain regions simultaneouslyDisparate brain regions such as the nucleus accumbensstriatumprefrontal cortexhippocampusand others have been widely known to have greatly varying ...

    STTR Phase I 2019 Department of Health and Human ServicesNational Institutes of Health
  7. Gene Therapy to Protect the Lung from Oxidant Stress

    SBC: LEXEO Therapeutics LLC            Topic: NHLBI

    AbstractThe focus of this proposal is the development of therapy to protect the lung with an extracellular anti oxidant defense to treat chronic obstructive pulmonary diseaseCOPDa chronic disorder in which inhaled oxidants from tobacco smokepollution and generated within the lung by activated inflammatory cells perpetuate injury to the lung epithelium and endotheliumThe LEXEO strategy is to use in ...

    STTR Phase I 2019 Department of Health and Human ServicesNational Institutes of Health
  8. Validation of a Cranial Neurosurgery Simulator and Assessment of Minimally Invasive Techniques

    SBC: Simulated Inanimate Models LLC            Topic: 103

    Project SummarySimulation training is unique in its ability for repetitive practice of a wide variety of scenarios and to reflect on performance without jeopardizing a patient s safetySurgical skills simulators have been successful in bridging gaps of the current training modelhoweverthese simulators fall short of offering a complete operative experienceOperative exposure with live patients still ...

    STTR Phase I 2019 Department of Health and Human ServicesNational Institutes of Health
  9. A recombinant matrix to improve autologous tissue grafts

    SBC: inSoma Bio Inc            Topic: 102

    Abstract The objective of this proposal is to validate a new regenerative tissue matrix which studies to date indicate may be possible of redefining the limits of autologous fat graftingThis objective is motivated by the currently limited surgical options available to themillion patients undergoing reconstructive plastic surgery each year to treat body disfigurement and dysfunctionA core component ...

    STTR Phase I 2019 Department of Health and Human ServicesNational Institutes of Health
  10. Improving the Oral Bioavailability and In vivo Efficacy of a Novel TAK1 Inhibitor Targeting Rheumatoid Arthritis

    SBC: EYDIS BIO, INC.            Topic: NIAMS

    Project SummaryAbstract Rheumatoid arthritisRAis a chronic inflammatory disease in which hyperactivated immune cells induce maladaptive persistent inflammation in the jointsleading to synovial inflammation and bone remodelingIn the USRA currently affects roughlyof the population and carries a total annual societal cost burden of approximately $billionIn RAsustained elevations of pro inflammatory c ...

    STTR Phase I 2019 Department of Health and Human ServicesNational Institutes of Health
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