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The Award database is continually updated throughout the year. As a result, data for the given year is not complete until April of the following year. Annual Reports data is a snapshot of agency reported information for that year and hence might look different from the live data in the Awards Information charts.

  1. Enhancing Clinical Therapy for wet Age-related Macular Degeneration (wetAMD)

    SBC: NANOHYBRIDS INC            Topic: N

    ABSTRACTThe wet form of age related macular degenerationAMDaccounts forof all AMD related blindness and affectsmillion people withnew cases each year in the USMinimally invasive and selective drug delivery to the eye still remains an open challengethe current standard of care involves delivery of antivascular endothelial growth factoranti VEGFdrugs via intraocular injectionFor patients refractory ...

    STTR Phase I 2018 Department of Health and Human Services
  2. Mulitplexed detector array for VOC biomarker development

    SBC: NANOHMICS INC            Topic: NIEHS

    Summary Volatile organic compoundsVOCsare known to be diagnostic for human healthHoweverthe ability to effectively diagnose and classify a disease state using only patient exhaled breath is the subject of great debateA recently published ACS NanoDecmulti national clinical study on breath diagnostics by Nakhleh et altitledDiagnosis and classification ofdiseases fromsubjects via pattern analysis of ...

    SBIR Phase I 2018 Department of Health and Human Services
  3. Zinc(II) Sensitive MRI Contrast Agents as Diagnostic Sensors for Tracking Insulin Secretion


    ABSTRACT SignificanceDiabetes mellitus typeT Dand particularly typeT Drtof casesare becoming an increasing burden on socioeconomic resources with vastly increasing patient numbers all over the worldInsulin dependent treatment regimen such as regular insulin injections are well established for both T D and T D but have been associated with a negative impact on the quality of life of patients with a ...

    SBIR Phase II 2018 Department of Health and Human Services
  4. Point-of-care monitoring of feto-placental oxygen uptake


    Point of care monitoring of feto placental oxygen uptake SummaryAbstract TheGreat Obstetrical syndromesare the leading cause of maternal and fetal mortality world wideDespite the factthat the origin of these syndromes is associated with pathology of deep placentation and abnormal vascular remodelingthere are no toolsallowing early point of care diagnosisprior to maternal pregnancy complication bec ...

    SBIR Phase I 2018 Department of Health and Human Services

    SBC: Tietronix Software, Inc.            Topic: NIEHS

    Abstract andampProject Summary The proposed research project is aimed at investigating the feasibility to provide an advanced virtual realityVRbased evaluation and training system for emergency responders involved in biosafety response and cleanupThis SBIR Phase I project will create a proof of concept prototype of a virtual environment for emergency response evaluation and training to emulate imm ...

    SBIR Phase I 2018 Department of Health and Human Services
  6. Proteasome inhibitor re-sensitizing molecules for treatment of refractory multiple myeloma

    SBC: Leukogene Therapeutics Inc.            Topic: 102

    Project Summary Abstract Multiple MyelomaMMis the second most common form of blood cancer and remains an incurable and deadly diseaseProteasome inhibitorPItherapy is a cornerstone in the treatment of MMbut resistance to this class of agent is an emerging challenge in the clinicNew therapeutic approaches that specifically target resistance are needed to maximize responses and ultimately produce cur ...

    STTR Phase II 2018 Department of Health and Human Services
  7. In Silico Identification of Novel GHB Receptor Ligands for SSADH Deficiency, a Disorder of GABA Metabolism

    SBC: SPERAGEN, INC.            Topic: 102

    Summary The most prevalent inherited disorder of GABA metabolismsuccinic semialdehyde dehydrogenase deficiencySSADHDpresents a non specific neurological phenotype associated with physiological accumulation of the major inhibitory neurotransmitter GABA and the GABAderivativehydroxybutyrateGHBAn absence of targeted therapy for SSADHD underlies this application s rationalePreclinical and clinical stu ...

    STTR Phase I 2018 Department of Health and Human Services
  8. A Double Balloon Catheter for the Treatment of Intussusception in Children

    SBC: Sealcath, LLC            Topic: NICHD

    PROJECT SUMMARY ABSTRACT During Phase ISealCathLLC will test the feasibility of its innovative Double Balloon CatheterDBCwhich the United States Utility Patent application was approved on Augustand is in the process of issuing a patentLicensed from the Medical University of South Carolinathis DBC will be commercialized in Phase III as the trademarked nameCephus Catheterwith targeted end users bein ...

    SBIR Phase I 2018 Department of Health and Human Services

    SBC: INDUS INSTRUMENTS            Topic: R

    TITLEUltrasonic Telemetric Implantable Pulsed Doppler Blood Flow Velocimeter for Small Animals ABSTRACT Ultrasonic Pulsed Doppler devices for measuring flow velocities in blood vessels of small animals such as mice are routinely used by cardiovascular researchers for preclinical researchUndisturbed and non tethered acquisition of physiologic data in awakeunanesthetizedanimals using wireless teleme ...

    SBIR Phase I 2018 Department of Health and Human Services
  10. Transcatheter Device for Congestive Heart Failure Treatment Through Left Atrial Decompression

    SBC: ALLEVIANT MEDICAL, INC.            Topic: NHLBI

    Project Summary Abstract DescriptionCongestive heart failureCHFis a chronic and progressive condition that currently affects overmillion patients in the USIt accounts for over $B in direct healthcare expenditure and over one million hospitalizations each yearPatients exhibit shortness of breathdecreased exercise tolerance and overall reduced quality of lifeDespite best medical therapythe prognosis ...

    SBIR Phase I 2018 Department of Health and Human Services

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